DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt304A1 and Ugt8

DIOPT Version :9

Sequence 1:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_062149.1	Gene:	Ugt8 / 50555	RGDID:	3938	Length:	541	Species:	Rattus norvegicus

Alignment Length:	531	Identity:	147/531 - (27%)
Similarity:	247/531 - (46%)	Gaps:	82/531 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PMFWLISNSICWIRSSRILVIAP--FESHSQCMLVTPYIQALKDRGHQLTVIHAYKHCMHKIEDV 72
            |.|.|:.:::...|:::|:::.|  ||||  ..:......||.:|||....:      :.:..|:
  Rat     6 PYFMLLWSAVGIARAAKIIIVPPIMFESH--LYIFKTLASALHERGHHTVFL------LSEGRDI 62

  Fly    73 TFIRIWYNNNVFLE-----FEESVGIASANNKWEEISS-----------MSSLMANATLNVLNNV 121
            .     .:|:..|:     |..:...|...:|...|.|           :.....|..:.|.|..
  Rat    63 D-----PSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAVELVDILDHYTKNCDMMVGNQA 122

  Fly   122 EVRALMKSRITFDAVVLEAGYSDVLYGMAAHFSAQLIGICTCVADWNINNLVGFSTSTL--TEPI 184
            .::.|.|.:  ||.::::..      .|.....|.|:|:...|          |||...  .|..
  Rat   123 LIQGLKKEK--FDLLLVDPN------DMCGFVIAHLLGVKYAV----------FSTGLWYPAEVG 169

  Fly   185 MPFRAKYV----------KNVWDRIYNWLYTTEEWLL----INLVFLPKQRLIHDHFFGHLEKSF 235
            .|....||          .|..:|:.|    |..:|:    ::.:.|||...|...:.....||.
  Rat   170 APAPLAYVPEFNSLLTDRMNFLERMKN----TGVYLISRMGVSFLVLPKYERIMQKYNLLPAKSM 230

  Fly   236 HEIRQDFALMLLNQHFSLFRARPNVPGMVEVAGLHIPKEDPQLPSDLQVFIDEA-EHGVIL--FS 297
            :::....:|.:|....:|...||.:|.:|.|.|: :.|....||.|||.::|.| |||.:|  |.
  Rat   231 YDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGI-LTKPASPLPEDLQRWVDGAQEHGFVLVSFG 294

  Fly   298 LGLEQDSKDLPRKTQEILVETFKSVPQRVIWKFDGESTMSLGTDIYHSKLLPQQAILAHPNVKLF 362
            .|::..|:|:..|    |......:||:|||:|.|....:||.:....:.|||..:|.|.|::.|
  Rat   295 AGVKYLSEDIANK----LAGALGRLPQKVIWRFSGTKPKNLGNNTKLIEWLPQNDLLGHSNIRAF 355

  Fly   363 ISHCGMMSVIEAAYYAKPVLGLPSFFDQFRNLEIMKEEGVALELNINSLTVKELKDAIHSMINEP 427
            :||.|:.|:.|..|:..||:|:|.|.|.:..:..::.:|:.:.|..|::|..||.||:..:||.|
  Rat   356 LSHGGLNSIFETMYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWNTVTEGELYDALVKVINNP 420

  Fly   428 EYRESALAISQRFRDQPIHPLDAAIYWTEYIIRYKGADHMKISQSQLKLFDYYSLD-NFIMVGSR 491
            .||:.|..:|:..:|||.||::...||.:||:|:.||.|::.:..|:....|:.|| .|::
  Rat   421 SYRQRAQKLSEIHKDQPGHPVNRTTYWIDYILRHDGAHHLRSAVHQISFCQYFLLDIAFVL---- 481

  Fly   492 LSLVVALVFLV 502
            |...|||.|:|
  Rat   482 LLGAVALYFIV 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	137/506 (27%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	115/437 (26%)
Ugt8	NP_062149.1	egt	8..490	CDD:223071	144/525 (27%)
Ugt8	NP_062149.1	UDPGT	21..502	CDD:278624	143/516 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344190
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.740