DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt304A1 and Ugt35D1

DIOPT Version :9

Sequence 1:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	520	Identity:	184/520 - (35%)
Similarity:	284/520 - (54%)	Gaps:	46/520 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PMFWLISNSICWIRSSRILVIAPFESHSQCMLVTPYIQALKDRGHQLTVIHAY--KHCMHKIEDV 72
            |:|.|:.....:...:|||.:.|..|.|......||:::|...||::|.:..|  :.....|.|:
  Fly     3 PIFLLVCLLPGYSEGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPYPQREPFRNIHDI 67

  Fly    73 TFIRIWYNNNVFLEFEESVGIASA-NNKWEEISSMSSLMANATLNVLNNVEVR--ALMKSRITFD 134
            ..      ..||..|.|.:.|||. .:.|:....::..:.|.|..||||..||  .|...:..||
  Fly    68 PV------PEVFENFNEVLRIASTPRSTWQSSDFINEYVLNLTKTVLNNEGVRRDILGPQKPHFD 126

  Fly   135 AVVLEAGYSDVLYGMAAHFSAQLIGICTCVADWNINNLVGFSTSTLTEPIMPFRAKYVKNVWDRI 199
            .|:::....|||.|:||:|.|.:||:.:...||.|:.|:|     ...||     .|:::...|.
  Fly   127 LVIMDLWRMDVLSGLAAYFDAPIIGMASYGTDWKIDELMG-----NVSPI-----SYLQSPSSRF 181

  Fly   200 YN---------------WLYTTEEWLLINLVFLPKQRLIHDHFFGHL--EKSFHEIRQDFALMLL 247
            |:               :.|...:|..:.     ||..::..||..:  .|...||.::|.|:|:
  Fly   182 YDLEAYGERLLHLMERTFSYMNYKWRHVR-----KQETLYSQFFPSVAERKPLSEISRNFDLVLV 241

  Fly   248 NQHFSLFRARPNVPGMVEVAGLHIPKEDPQLPSDLQVFIDEA-EHGVILFSLGLEQDSKDLPRKT 311
            ||||:|...||.||.|::|.|||:......|.::|..||..| |.|||.||||....||.|....
  Fly   242 NQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYFSLGTNVKSKSLSEDR 306

  Fly   312 QEILVETFKSVPQRVIWKFDGESTMSLGTDIYHSKLLPQQAILAHPNVKLFISHCGMMSVIEAAY 376
            :::|:|||.|:|||::|||:.|.......:::.||..|||||||||||||||:|.|::|.||:.:
  Fly   307 RKVLLETFASLPQRIVWKFEDELLPGKPPNVFISKWFPQQAILAHPNVKLFITHGGLLSTIESIH 371

  Fly   377 YAKPVLGLPSFFDQFRNLEIMKEEGVALELNINSLTVKELKDAIHSMINEPEYRESALAISQRFR 441
            :.||:||||..||||||::.:::.|:.|.|||..:|.:|.:..|..::....:.|:|...:.|:|
  Fly   372 HGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLLTNKSFEETARITAARYR 436

  Fly   442 DQPIHPLDAAIYWTEYIIRYKGADHMKISQSQLKLFDYYSLDNF--IMVGSRLSLVVALVFLVLS 504
            |||:.|::.||:||||::.:|||.||:::...|....|:|||.|  .:||:.:.|.:....||::
  Fly   437 DQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTFLVGALVILGIVTYLLVMT 501

Fly 505 504
Fly 502 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	174/492 (35%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	151/425 (36%)
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	171/479 (36%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	176/493 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445601
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D45181at50557
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	10	9.800