DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt304A1 and Ugt1a2

DIOPT Version :9

Sequence 1:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_958826.1	Gene:	Ugt1a2 / 396527	RGDID:	1549741	Length:	533	Species:	Rattus norvegicus

Alignment Length:	521	Identity:	131/521 - (25%)
Similarity:	239/521 - (45%)	Gaps:	63/521 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LISNSICWIRSSRILVIAPFESHSQCMLVTPYIQALKDRGHQLTVIHAYKHCMH-KIEDVTFIRI 77
            |:..::.|....::||. |.|. |..:.:...::.|..||||..|: |.:..:| |.||...::.
  Rat    17 LLLCALPWAEGGKVLVF-PMEG-SHWLSMRDVVRELHARGHQAVVL-APEVTVHMKGEDFFTLQT 78

  Fly    78 WYNNNVFLEFEESVGIASANNKWE-------------EISSMSSLMANATLNVLNNVEVRALMKS 129
            :.......|::..: :.:|...:|             .|.....|.||:...:|:|..:...:.|
  Rat    79 YAFPYTKEEYQREI-LGNAKKGFEPQHFVKTFFETMASIKKFFDLYANSCAALLHNKTLIQQLNS 142

  Fly   130 RITFDAVVLEAGYSDVLYGMAAHFSAQL-------IGICTCVADWNINNLVGFSTSTLTEPIMPF 187
            . :||.|:     :|.::...|..:..|       :....|..|:....             .|.
  Rat   143 S-SFDVVL-----TDPVFPCGALLAKYLQIPAVFFLRSVPCGIDYEATQ-------------CPK 188

  Fly   188 RAKYVKNV----------WDRIYNWLYTTEEWLLINLVFLPKQRLIHDHFFGHLEKSFHEIRQDF 242
            .:.|:.|:          ..|:.|.||......:.:|...|.:.|..:..  ..|.|..|:....
  Rat   189 PSSYIPNLLTMLSDHMTFLQRVKNMLYPLTLKYICHLSITPYESLASELL--QREMSLVEVLSHA 251

  Fly   243 ALMLLNQHFSLFRARPNVPGMVEVAGLHIPKEDPQLPSDLQVFID-EAEHGVILFSLGLEQDSKD 306
            ::.|....|.....||.:|.||.:.|::...:.| |..:.:.::: ..|||:::||||  ....:
  Rat   252 SVWLFRGDFVFDYPRPIMPNMVFIGGINCVIKKP-LSQEFEAYVNASGEHGIVVFSLG--SMVSE 313

  Fly   307 LPRKTQEILVETFKSVPQRVIWKFDGESTMSLGTDIYHSKLLPQQAILAHPNVKLFISHCGMMSV 371
            :|.|....:.|....:||.|:|::.|....:|..:....|.|||..:|.||..:.||:|.|...:
  Rat   314 IPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGI 378

  Fly   372 IEAAYYAKPVLGLPSFFDQFRNLEIMKEEGVALELNINSLTVKELKDAIHSMINEPEYRESALAI 436
            .|......|::.:|.|.||..|.:.|:..|..:.||:..:|..:|::|:.::||...|:|:.:.:
  Rat   379 YEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRL 443

  Fly   437 SQRFRDQPIHPLDAAIYWTEYIIRYKGADHMKISQSQLKLFDYYSLDNFIMVGSRLSLVVALVFL 501
            |...:|:||.|||.|::|.||::|:|||.|::.:...|..:.|:|||   ::|..|::|:.:||:
  Rat   444 SSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLD---VIGFLLAIVLTVVFI 505

  Fly   502 V 502
            |
  Rat   506 V 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	121/497 (24%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	99/434 (23%)
Ugt1a2	NP_958826.1	UDPGT	28..524	CDD:278624	129/510 (25%)
Ugt1a2	NP_958826.1	egt	<261..507	CDD:223071	80/252 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.860