DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt304A1 and Ugt36E1

DIOPT Version :9

Sequence 1:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	147/525 - (28%)
Similarity:	250/525 - (47%)	Gaps:	42/525 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GRWLLPMFWLISNSICWIRSSRILVIAPFESHSQCMLVTPYIQALKDRGHQLTVI---------H 60
            |.|.:.....:.:.:.:..|.|||.:.|..:.|......|.::.|.:.||.:.||         :
  Fly     3 GCWKVFCLLALLSLVAFSDSLRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVISPFEDKDPPN 67

  Fly    61 AYKHCMHKIEDVTFIRIWYNNNVFLE-FEESVGIASANNKWEEISSMSSLMANATLNVLNNVEVR 124
            .||.  |.:...|.     .:.:.|| ||..........::..:..|.....|.||:.....|:
  Fly    68 GYKD--HLLPPSTL-----TDTISLEDFERPYSFLFHYVEFFILHKMGREDCNTTLHSRALTEI- 124

  Fly   125 ALMKSRITFDAVVLEAGYSDVLYGMAAHFSAQLIGICTCVADWNINNLVGFSTSTLTEPIMPFRA 189
             |......:|.::||...:|....:|..|.|.:||:.:|.       |:.:.......|::|
  Fly   125 -LKNPPGYYDVILLEQFNTDCAMSVAHVFQAPVIGMSSCA-------LMPWHYERFGAPLIP--- 178

  Fly   190 KYVKNVWD----------RIYNWLYTTEEWLLINLVFLPKQRLIHDHFFGHLEKSFHEIRQDFAL 244
            .|:..::.          |:.||:......||..:..:|....:....||....|..::.::.:|
  Fly   179 SYISALFQGQSQEMSFAGRLGNWITVHSLNLLYKMFTVPAGNALIRQRFGPGLPSTEDLVRNTSL 243

  Fly   245 MLLNQHFSLFRARPNVPGMVEVAGLHIPKEDPQLPSDLQVFIDEAEHGVILFSLGLEQDSKDLPR 309
            ||:||||||...:|..|.::||.|:||....| ||||||..:|.|..||||.|.|.:..:..|..
  Fly   244 MLVNQHFSLSGPKPLPPNVIEVGGVHISPPKP-LPSDLQKILDNAPKGVILISWGSQLKACSLSA 307

  Fly   310 KTQEILVETFKSVPQRVIWKFDGESTMSLGTDIYHSKLLPQQAILAHPNVKLFISHCGMMSVIEA 374
            ..::.:|:....:.|.||||::.::..:...:::..|.|||:.||||||:|:|:||.|:|...||
  Fly   308 ARRDGIVKAIGRLEQEVIWKYENDTLPNKPPNLHIRKWLPQRDILAHPNLKVFMSHGGLMGTTEA 372

  Fly   375 AYYAKPVLGLPSFFDQFRNLEIMKEEGVALELNINSLTVKELKDAIHSMINEPEYRESALAISQR 439
            ...|.|::|:|.:.||..|:..:.:.|:||:|.:..|....:.:|:...: :|.::..|..::..
  Fly   373 VSSAVPIVGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYEALTKAL-DPSFKARAKEVASS 436

  Fly   440 FRDQPIHPLDAAIYWTEYIIRYKGADHMKISQSQLKLFDYYSLDNFIMVGSRLSL-VVALVFLVL 503
            :.::...||:.||:|.|::...|||...:.|...|..|.|||||.:.:|...|.| |:.|:.|:.
  Fly   437 YNNRIQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDVYSVVALSLLLPVITLLGLIR 501

  Fly   504 SKSRR 508
            ...||
  Fly   502 MFKRR 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	132/491 (27%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	114/422 (27%)
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	128/477 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454623
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.890