DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt304A1 and Ugt307A1

DIOPT Version :9

Sequence 1:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_609097.2	Gene:	Ugt307A1 / 33993	FlyBaseID:	FBgn0031887	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	149/534 - (27%)
Similarity:	247/534 - (46%)	Gaps:	87/534 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PMFWLISNSICWIRSSRILVI----APFESH-----------SQCMLVTPYIQALKDRGHQLTVI 59
            |:.|    |:.|:..:.|.::    ||.|||           ||.|:.....:||..|||.||::
  Fly     5 PISW----SLLWMGYTCIFLLADSPAPVESHHILGLFVNVHRSQLMVHLAVCRALLQRGHHLTLV 65

  Fly    60 HAYKHCMHKIEDVTFIRIWYNNNVFLEFEESVG-IASANNKW----EEISSMSSLMANATL---- 115
                                 ..:.||.:|..| ::.....|    ||:||...::....:
  Fly    66 ---------------------TTLPLEEQEIQGNVSHIYIPWQQPKEEVSSSDLILRLERMFRRL 109

  Fly   116 ----NVLNNVEVRALMKSR--ITFDAVVLEAGYSDVLYGMAAHFSAQLIGICTCVADWNINNLVG 174
                ::|:..|.:..::::  ..:|.::|...::|.|.|:||||:..:..:.|......:|:|:|
  Fly   110 EHSGDLLDLPEWKMFLRNQPNTPYDLLLLGYHFNDHLLGVAAHFNCPVAIVSTQQPTGFVNSLMG 174

  Fly   175 FSTSTLTEPIMPFRAKYVKNVWD-----RIYNWLYTTEEWLLINLVFLPKQRLIHDHFFGHLEKS 234
                      .|....||...:|     .|..|::...|..:..|......|:...||......|
  Fly   175 ----------NPEERWYVPQPYDGQQRSGISAWVFGMWEKFMEILARRVLARIYRLHFPEPQYPS 229

  Fly   235 FHEIRQDFALMLLNQH-FSLFRARPNVPGMVEVAGLHIPKEDPQLPSDLQVFIDEAEHGVILFSL 298
            |..:|:...|.|.|.| .|.....|.:|.||::.|:.:.::..:.|.:    |......:|:|||
  Fly   230 FETMRRSVVLALSNHHMISEGPIAPLIPSMVDIGGIVLEQQLDKTPLE----ISAGNRSLIIFSL 290

  Fly   299 GLEQDSKDLPRKTQEILVETF-KSVPQ----RVIWKFDGESTMSLGTDIYHSKLL---PQQAILA 355
            |    ::...||:.:.||.|| |:..|    .:.|.:||.:..::..|..|.|:.   ||..:..
  Fly   291 G----TRFTWRKSTKELVRTFTKAFAQFPDYDIYWTYDGPNGSAISLDYPHLKVAKWWPQTQMWQ 351

  Fly   356 HPNVKLFISHCGMMSVIEAAYYAKPVLGLPSFFDQFRNLEIMKEEGVALELNINSLTVKELKDAI 420
            ...|:|||:|.|..||.||.:|..|:||||...||..||:.|:.:...|.|:.|:||..:|..||
  Fly   352 SGKVRLFITHGGKGSVSEALFYGVPMLGLPLIGDQRDNLQRMQSKNWGLTLSTNNLTHWKLAKAI 416

  Fly   421 HSMINEPEYRESALAISQRFRDQPIHPLDAAIYWTEYIIRYKGADHMKISQSQLKLFDYYSLDNF 485
            ..|:::..|.|:.|..||.:||:|:.|.|...||.|||:|:|||.::.....||.:.:|:|:|.:
  Fly   417 TRMLSDSSYGETILKASQLYRDRPVSPSDLVTYWIEYIVRHKGAKNLHNPARQLNIIEYHSIDVY 481

  Fly   486 IMVGSRLSLVVALV 499
            .:|...|.|.:|::
  Fly   482 FIVYGLLILTIAIL 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	142/513 (28%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	115/431 (27%)
Ugt307A1	NP_609097.2	egt	13..492	CDD:223071	144/517 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445772
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.950