DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt304A1 and Ugt2b10

DIOPT Version :9

Sequence 1:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001178605.1	Gene:	Ugt2b10 / 305264	RGDID:	1309989	Length:	532	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	127/527 - (24%)
Similarity:	247/527 - (46%)	Gaps:	95/527 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LVIAPFESHSQCMLVTPYIQALKDRGHQLTVIHAYKHCMHKIEDVTFIR---------------- 76
            :::.|.| .|..:.:...:..|..:||::||:.......:::::.:.|.
  Rat    28 VLVWPME-FSHWLNLRVILDELLKKGHEVTVLRPSASLSYEVDNTSAIEFETYPTSYSLTEVDEF 91

  Fly    77 ----------------IWYNNNVFLEFEESVGIASANNKWEEISSMSSLMANATLNVLNNVEVRA 125
                            .|   ..||.|:|.|        |.:.....||..    :|:.|.|:..
  Rat    92 FWESLRKYIYELPKQSFW---GYFLMFQELV--------WVDSDYFESLCK----DVVFNKELMT 141

  Fly   126 LMKSRITFDAVVLE--AGYSDVLYGMAAHFSAQLIGICTCVADWNINNLVGFSTSTLTEPI--MP 186
            .:::. .||.::.:  ....|:|        |:::.|..      :.:|..|..||..:..  :|
  Rat   142 KLQNS-GFDVILADPFIPCGDLL--------AEILKIPL------VYSLRFFPGSTYEKYSGGLP 191

  Fly   187 FRAKYVKNVWDRIYNWLYTTEEWLLINLVFLPKQRLIHDHFF-GHLEKSFHEIRQDFA------- 243
            ....||......:.:.:...|.  :.:::::    |..|.:| ...||.::|:..:..
  Rat   192 MPPSYVPIAMSELSDRMTFVER--MKHMIYV----LCFDFWFQAFNEKKWNELYTEVLGRPTTLS 250

  Fly   244 -------LMLLNQHFSLFRARPNVPGMVEVAGLHIPKEDPQLPSDLQVFIDEA-EHGVILFSLGL 300
                   :.|:..::.|....|.:|....|.|||.....| ||.:::.|:..: ||||::||||
  Rat   251 ETMAKADIWLIRTYWDLEFPHPVLPNFDFVGGLHCRPAKP-LPKEIEDFVQSSGEHGVVVFSLG- 313

  Fly   301 EQDSKDLPRKTQEILVETFKSVPQRVIWKFDGESTMSLGTDIYHSKLLPQQAILAHPNVKLFISH 365
             ....:|..:...::......:||:|:|:|:|:...:||::....|.:||..:|.||..:.||:|
  Rat   314 -SMVGNLTEERANVIAAGLAQIPQKVLWRFEGKKPETLGSNTRLYKWIPQNDLLGHPKTRAFITH 377

  Fly   366 CGMMSVIEAAYYAKPVLGLPSFFDQFRNLEIMKEEGVALELNINSLTVKELKDAIHSMINEPEYR 430
            .|...:.||.|:..||:|:|.|.||:.|:..:|.:|.|:.|:..:::..:|..|:.::.|:|.|:
  Rat   378 GGTNGIYEAIYHGIPVVGIPLFGDQYDNIVHLKTKGAAVRLDFLTMSSTDLFTALKTITNDPSYK 442

  Fly   431 ESALAISQRFRDQPIHPLDAAIYWTEYIIRYKGADHMKISQSQLKLFDYYSLDNFIMVGSRLSLV 495
            |:|:.:|:...|||:.|||.|::|.|:::|:|||.|::::...|....|:|||   ::|..|:.|
  Rat   443 ENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWVQYHSLD---VIGFLLACV 504

  Fly   496 VALVFLV 502
            |.::|::
  Rat   505 VTVMFIL 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	118/503 (23%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	102/454 (22%)
Ugt2b10	NP_001178605.1	UDPGT	26..529	CDD:278624	127/527 (24%)
Ugt2b10	NP_001178605.1	egt	35..510	CDD:223071	124/516 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344100
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830