DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt304A1 and Ugt1a8

DIOPT Version :9

Sequence 1:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_787040.2	Gene:	Ugt1a8 / 301595	RGDID:	708474	Length:	530	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	137/546 - (25%)
Similarity:	251/546 - (45%)	Gaps:	95/546 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PPGRWLLPMFWLISNSICWIRSSRILVIAPFESHSQCMLVTPYIQALKDRGHQLTVI------HA 61
            ||...|....:|.|.   :.::.|:||:....||...|.:  .::.|..|||::.|:      |.
  Rat     7 PPSLPLCVCLFLASG---FAQAGRLLVVPMDGSHWFTMQM--IVEKLSHRGHEVVVVIPEVSWHM 66

  Fly    62 YKHCMHKIEDVTFIRIWYNNNVFLEFEESVGIASANNKW--EEISSMSSLMANATLNVLNNV--E 122
            .|.....::..:......:.|...:|       .|:|:|  :|: .|.||:.::.......:  .
  Rat    67 GKSLNFTVKTYSVSYTLEDLNYHFKF-------FAHNQWKTQEV-GMFSLLKHSGKGFFELLFSH 123

  Fly   123 VRALMKSR--------ITFDAVVLE---------AGY---SDVLY--GMAAHF---SAQLIGICT 162
            .|:|.|.:        .:||||.|:         |.|   ..|::  |:..|:   .||    |.
  Rat   124 CRSLFKDKKLVEYLKQSSFDAVFLDPFDVCGLILAKYFSLPSVVFSGGIFCHYLDEGAQ----CP 184

  Fly   163 CVADWNINNLVGFSTSTLTEPIMPFRAKYVKNVWDRIYNWLYTTEEWLLINLVFLPKQRLIHDHF 227
            ....: :..::...|.|:|         :.:.||:               :|.:: |:|....:|
  Rat   185 SPPSY-VPRILSKFTDTMT---------FKERVWN---------------HLSYM-KERAFCPYF 223

  Fly   228 FGHLEKSFHEIRQ----------DFALMLLNQHFSLFRARPNVPGMVEVAGLHIPKEDPQLPSDL 282
            |....:...|:.|          ..::.:....|.|...||.:|.||.:.|::..:..| |..:.
  Rat   224 FKTAVEIASEVLQTPVTMRDLFSPVSIWMFRTDFVLEFPRPVMPNMVYIGGINCHQGKP-LSKEF 287

  Fly   283 QVFID-EAEHGVILFSLGLEQDSKDLPRKTQEILVETFKSVPQRVIWKFDGESTMSLGTDIYHSK 346
            :.::: ..|||:::||||  ....::|.|....:.|....:||.|:|::.|....:|..:....|
  Rat   288 EAYVNASGEHGIVVFSLG--SMVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVK 350

  Fly   347 LLPQQAILAHPNVKLFISHCGMMSVIEAAYYAKPVLGLPSFFDQFRNLEIMKEEGVALELNINSL 411
            .|||..:|.||..:.||:|.|...:.|......|::.:|.|.||..|.:.|:..|..:.||:..:
  Rat   351 WLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEM 415

  Fly   412 TVKELKDAIHSMINEPEYRESALAISQRFRDQPIHPLDAAIYWTEYIIRYKGADHMKISQSQLKL 476
            |..:|::|:.::||...|:|:.:.:|...:|:||.|||.|::|.||::|:|||.|::.:...|..
  Rat   416 TADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTW 480

  Fly   477 FDYYSLDNFIMVGSRLSLVVALVFLV 502
            :.|:|||   ::|..|::|:.:||:|
  Rat   481 YQYHSLD---VIGFLLAIVLTVVFIV 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	125/517 (24%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	101/448 (23%)
Ugt1a8	NP_787040.2	UDPGT	26..521	CDD:278624	132/524 (25%)
Ugt1a8	NP_787040.2	egt	<263..504	CDD:223071	80/247 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.860