DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt304A1 and Ugt2b37

DIOPT Version :9

Sequence 1:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001007265.4	Gene:	Ugt2b37 / 29623	RGDID:	3937	Length:	530	Species:	Rattus norvegicus

Alignment Length:	565	Identity:	139/565 - (24%)
Similarity:	241/565 - (42%)	Gaps:	128/565 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PGRWLLPMFWLISNSICWIRSSRI--LVIAPFESHSQCMLVTPYIQALKDRGHQLTVIHAYKHCM 66
            ||:|:..:. |:..|.| :||::.  :::.|.| .|..|.:...:..|..|||::||:   |...
  Rat     2 PGKWIFALL-LLQISFC-LRSAKCGKVLVWPME-FSHWMNIKTILDELVQRGHEVTVL---KPSA 60

  Fly    67 HKIEDVTFIRIWYNNNVFLEFEESVGIASANNKWEEISSMSSLMANATLNVLNNVEVRALMKSRI 131
            :.:.|.       ..:..|:||                   :...:.:.:.|....::.:
  Rat    61 YYVLDP-------KKSPDLKFE-------------------TFPTSVSKDELEKYFIKLV----- 94

  Fly   132 TFDAVVLE------AGYSDVLYGMAAHFSAQLIGICTCVADWNINNLVGFSTS----TLTEPI-- 184
              ||...|      ..:|.:|..|...||...:.:|..... |...:.....|    .|::|:
  Rat    95 --DAWTYELQRDTCLSFSPLLQNMMDEFSDYYLSVCKDAVS-NKQLMAKLQESKFDVLLSDPVAA 156

  Fly   185 ----------MPF----RA-----------------KYVKNVW----------DRIYN------- 201
                      :||    ||                 .||..:.          ||:.|
  Rat   157 CGELIAEVLHIPFLYSLRASPGHKIEKSSGRFILPPSYVPVILSGLGGQMTFIDRVKNMICMLYF 221

  Fly   202 --W--LYTTEEWLLINLVFLPKQRLIHDHFFGHL---EKSFHEIRQDFALMLLNQHFSLFRARPN 259
              |  ::..:.|               |.|:..:   ..:..|......:.|:..::.|....|.
  Rat   222 DFWFHMFNAKNW---------------DPFYTEILGRPTTLAETMGKAEMWLIRSYWDLEFPHPT 271

  Fly   260 VPGMVEVAGLHIPKEDPQLPSDLQVFIDEA-EHGVILFSLGLEQDSKDLPRKTQEILVETFKSVP 323
            :|.:..:.||......| ||.|::.|:..: ||||::||||....|  :..:....:......:|
  Rat   272 LPNVDYIGGLQCKPAKP-LPKDIEDFVQSSGEHGVVVFSLGSMVSS--MTEEKANAVAWALAQIP 333

  Fly   324 QRVIWKFDGESTMSLGTDIYHSKLLPQQAILAHPNVKLFISHCGMMSVIEAAYYAKPVLGLPSFF 388
            |:|:|||||:...:||.:....|.|||..:|.||..|.|::|.|...|.||.|:..|::|:|.|.
  Rat   334 QKVLWKFDGKIPATLGPNTRVYKWLPQNDLLGHPKTKAFVTHGGANGVYEAIYHGIPMIGIPMFG 398

  Fly   389 DQFRNLEIMKEEGVALELNINSLTVKELKDAIHSMINEPEYRESALAISQRFRDQPIHPLDAAIY 453
            :|..|:..|..:|.|:.|||.:::..:|.:|:..:||.|.|:::|:.:|....|||:.|||.||:
  Rat   399 EQHDNIAHMVAKGAAVTLNIRTMSKSDLFNALKEVINNPFYKKNAMWLSTIHHDQPMKPLDKAIF 463

  Fly   454 WTEYIIRYKGADHMKISQSQLKLFDYYSLDNFIMVGSRLSLVVAL 498
            |.||::|:|.|.|::.....|..:.|:|||....:.:.|:::.||
  Rat   464 WIEYVMRHKRAKHLRPLGHNLPWYQYHSLDVIGFLLACLAVIAAL 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	129/541 (24%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	106/470 (23%)
Ugt2b37	NP_001007265.4	UDPGT	24..527	CDD:278624	131/541 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.760