DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt304A1 and Ugt2b7

DIOPT Version :9

Sequence 1:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_775445.2	Gene:	Ugt2b7 / 286989	RGDID:	708417	Length:	529	Species:	Rattus norvegicus

Alignment Length:	562	Identity:	130/562 - (23%)
Similarity:	255/562 - (45%)	Gaps:	115/562 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PGRWLLPMFWLISNSICWIRSSRI--LVIAPFESHSQCMLVTPYIQALKDRGHQLTVIHAYKHCM 66
            |.:|:..:. |:..|.|: ||...  :::.|.| :|..|.:...:..|..|||::||:..
  Rat     2 PQKWISALL-LLQISFCF-RSGNCGKVLVWPLE-YSHWMNLKIILDELVQRGHEVTVLRP----- 58

  Fly    67 HKIEDVTFIRIWYNNNVFLEFEESVGI------ASANN--------KW----------------- 100
                         :::|||:.:::.|:      .::||        :|
  Rat    59 -------------SSSVFLDPKKASGLVYETFPTTSNNDEVEKFFTQWVNTWTYDVPKYTCLRYY 110

  Fly   101 ----EEISSMSSLMANATLNVLNNVEVRALMKSRITFDAVVLEAGYSDVLYGMAAHFSAQLIGIC 161
                :.....|.|.......|::|..:.|.:|.. .||.|:.:|      .|......|:::.:.
  Rat   111 PSLNKMFGQFSDLWLQLCREVVSNKHLMAKLKES-QFDVVLSDA------VGPCGELIAEILQLP 168

  Fly   162 TCVADWNINNLVGFSTSTLTEPIMPFRAKYVKNV----------WDRIYNWL-----------YT 205
            ..   :::...:|:.....:.. .||...||..:          .:|:.|.|           :.
  Rat   169 FV---YSLRFGIGYGIEKYSAG-QPFPPSYVPIILSGLSGQMTFMERVENMLCLLYFDFWFESFP 229

  Fly   206 TEEWLLINLVFLPKQRLIHDHFFGHL---EKSFHEIRQDFALMLLNQHFSLFRARPNVPGMVEVA 267
            .::|               |.||..:   ..:..:..:...:.|:..::.|...||::|.:..|.
  Rat   230 AKDW---------------DPFFSEILGRPTTMVDTMKKAEIWLIRSYWDLEFPRPSLPNIEFVG 279

  Fly   268 GLHIPKEDPQLPSDLQVFIDEA-EHGVILFSLGLEQDSKDLPRKTQEILVETFKSVPQRVIWKFD 331
            |||.....| ||.:::.|...: ||||::||||  ...:::.::....:......:||:|.|:|:
  Rat   280 GLHCQPAKP-LPKEMEDFAQSSGEHGVVVFSLG--SMIRNITQERANTIASALAQIPQKVFWRFE 341

  Fly   332 GESTMSLGTDIYHSKLLPQQAILAHPNVKLFISHCGMMSVIEAAYYAKPVLGLPSFFDQFRNLEI 396
            |:...:||.:....|.:||..:|.||..|.|::|.|...:.|:.::..|::|:|.|.:|..|:..
  Rat   342 GKKPDTLGPNTRVFKWIPQNDLLGHPKTKAFVTHGGANGIYESIHHGIPMVGIPLFAEQRDNVAH 406

  Fly   397 MKEEGVALELNINSLTVKELKDAIHSMINEPEYRESALAISQRFRDQPIHPLDAAIYWTEYIIRY 461
            |..:|.|:.|:.::::..:|.:|:.::||:|.|::..:.:|....|||:.|||.|::|.|:::|:
  Rat   407 MVAKGAAVSLDFHTMSSSDLLNALKAVINKPSYKKKVMWLSAIHHDQPLKPLDRAVFWIEFVMRH 471

  Fly   462 KGADHMKISQSQLKLFDYYSLDNFIMVGSRLSLVVALVFLVL 503
            |||.|::.....|..:.|:|||   ::|..|:.|:|:|.|.:
  Rat   472 KGAKHLRPLAHNLAWYQYHSLD---VIGFLLACVLAIVLLAV 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	118/533 (22%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	96/462 (21%)
Ugt2b7	NP_775445.2	UDPGT	24..527	CDD:278624	123/538 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.860