DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt304A1 and Ugt8a

DIOPT Version :9

Sequence 1:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_035804.2	Gene:	Ugt8a / 22239	MGIID:	109522	Length:	541	Species:	Mus musculus

Alignment Length:	532	Identity:	144/532 - (27%)
Similarity:	246/532 - (46%)	Gaps:	81/532 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PMFWLISNSICWIRSSRILVIAP--FESHSQCMLVTPYIQALKDRGHQLTVIHAYKHCMHKIEDV 72
            |.|.|:.:::...|:::|:::.|  ||||  ..:......||.:|||...::      :.:..|:
Mouse     6 PYFMLLWSAVGIARAAKIIIVPPIMFESH--LYIFKTLASALHERGHHTVLL------LSEGRDI 62

  Fly    73 TFIRIWYNNNVFLE-----FEESVGIASANNKWEEISS-----------MSSLMANATLNVLNNV 121
            .     .:|:..|:     |..:...|...:|...|.|           :.....|..:.|.|..
Mouse    63 A-----PSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAVELVDILDHYTKNCDMMVGNQA 122

  Fly   122 EVRALMKSRITFDAVVLEAGYSDVLYGMAAHFSAQLIGICTCVADWNINNLVGFSTSTL--TEPI 184
            .::.|.|.:  ||.::::..      .|.....|.|:|:...|          |||...  .|..
Mouse   123 LIQGLKKEK--FDLLLVDPN------DMCGFVIAHLLGVKYAV----------FSTGLWYPAEVG 169

  Fly   185 MPFRAKYV----------KNVWDRIYNWLYTTEEWLL----INLVFLPKQRLIHDHFFGHLEKSF 235
            .|....||          .|..:|:.|    |..:|:    ::.:.|||...|...:.....||.
Mouse   170 APAPLAYVPEFNSLLTDRMNFLERMKN----TGVYLISRIGVSFLVLPKYERIMQKYNLLPAKSM 230

  Fly   236 HEIRQDFALMLLNQHFSLFRARPNVPGMVEVAGLHIPKEDPQLPSDLQVFIDEA-EHGVIL--FS 297
            :::....:|.:|....:|...||.:|.:|.|.|: :.|....||.|||.::..| |||.:|  |.
Mouse   231 YDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGI-LTKPASPLPEDLQRWVSGAQEHGFVLVSFG 294

  Fly   298 LGLEQDSKDLPRKTQEILVETFKSVPQRVIWKFDGESTMSLGTDIYHSKLLPQQAILAHPNVKLF 362
            .|::..|:|:..|    |......:||:|||:|.|....:||.:....:.|||..:|.|.|::.|
Mouse   295 AGVKYLSEDIANK----LAGALGRLPQKVIWRFSGTKPKNLGNNTKLIEWLPQNDLLGHSNIRAF 355

  Fly   363 ISHCGMMSVIEAAYYAKPVLGLPSFFDQFRNLEIMKEEGVALELNINSLTVKELKDAIHSMINEP 427
            :||.|:.|:.|..|:..||:|:|.|.|.:..:..::.:|:.:.|..|::|..||.||:..:||.|
Mouse   356 LSHGGLNSIFETMYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWNTVTEGELYDALVKVINNP 420

  Fly   428 EYRESALAISQRFRDQPIHPLDAAIYWTEYIIRYKGADHMKISQSQLKLFDYYSLDNFIMVGSRL 492
            .||:.|..:|:..:|||.||::...||.:||:|:.||.|::.:..|:....|:.||    :...|
Mouse   421 SYRQRAQKLSEIHKDQPGHPVNRTTYWIDYILRHDGARHLRSAVHQISFCQYFLLD----IAFVL 481

  Fly   493 SLVVALVFLVLS 504
            .|...|::.:||
Mouse   482 LLGAVLLYFILS 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	136/506 (27%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	114/437 (26%)
Ugt8a	NP_035804.2	UDPGT	21..502	CDD:278624	140/517 (27%)
Ugt8a	NP_035804.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	518..541
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840745
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.790