DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt304A1 and Ugt1a2

DIOPT Version :9

Sequence 1:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_038729.1	Gene:	Ugt1a2 / 22236	MGIID:	3576049	Length:	533	Species:	Mus musculus

Alignment Length:	520	Identity:	130/520 - (25%)
Similarity:	244/520 - (46%)	Gaps:	61/520 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LISNSICWIRSSRILVIAPFESHSQCMLVTPYIQALKDRGHQLTVIHAYKHCMH-KIEDVTFIRI 77
            |:..::.|...:::||: |.|. ||.:.:...::.|..|||| ||:.|.:..:| |.||...::.
Mouse    17 LLLCALPWAEGAKVLVL-PMEG-SQWLSMRDVVRELHARGHQ-TVVLASEVTVHIKGEDFFTLKT 78

  Fly    78 W--------YNNNVFLEFEESVG----IASANNKWEEISSMSSLMANATLNVLNNVEVRALMKSR 130
            :        |...:..:.|::..    :.:.......|.:...|.:|:.:.:|:|..:...:.|.
Mouse    79 YAFPYTKEEYQQEILSDIEKTFKTQHFVKAFFETTASIRNFFDLYSNSCIALLHNKMLIQQLNSS 143

  Fly   131 ITFDAVVLEAGYSDVLYGMAAHFSAQL-------IGICTCVADWNINNLVGFSTSTLTEPIMPFR 188
            . ||.::     :|.::...|..:..|       :...:|..::....             .|..
Mouse   144 F-FDVIL-----TDPIFPCGAVLAKYLQIPAVFILRSLSCGIEYEATQ-------------CPNP 189

  Fly   189 AKYVKNV----------WDRIYNWLYTTEEWLLINLVFLPKQRLIHDHFFGHLEKSFHEIRQDFA 243
            :.|:.|:          ..|:.|.||......:..|...|.:.|..:..  ..|.|..|:....:
Mouse   190 SSYIPNLLTRLSDHMDFLQRVQNMLYYLVLKYICRLSITPYESLASELL--QREVSLVEVLSHAS 252

  Fly   244 LMLLNQHFSLFRARPNVPGMVEVAGLHIPKEDPQLPSDLQVFID-EAEHGVILFSLGLEQDSKDL 307
            :.|....|.|...||.:|.||.:.|::...:.| |..:.:.::: ..|||:::||||  ....::
Mouse   253 VWLFRGDFVLDYPRPIMPNMVFIGGINCVTKKP-LSQEFEAYVNASGEHGIVVFSLG--SMVSEI 314

  Fly   308 PRKTQEILVETFKSVPQRVIWKFDGESTMSLGTDIYHSKLLPQQAILAHPNVKLFISHCGMMSVI 372
            |.|....:.|....:||.|:|::.|....:|..:....|.|||..:|.||..:.||:|.|...:.
Mouse   315 PEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIY 379

  Fly   373 EAAYYAKPVLGLPSFFDQFRNLEIMKEEGVALELNINSLTVKELKDAIHSMINEPEYRESALAIS 437
            |......|::.:|.|.||..|.:.|:..|..:.||:..:|..:|::|:.::||...|:|:.:.:|
Mouse   380 EGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLS 444

  Fly   438 QRFRDQPIHPLDAAIYWTEYIIRYKGADHMKISQSQLKLFDYYSLDNFIMVGSRLSLVVALVFLV 502
            ...:|:||.|||.|::|.||::|:|||.|::.:...|..:.|:|||   ::|..|::|:.:||:|
Mouse   445 SLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLD---VIGFLLAIVLTVVFIV 506

Fly 503 502
Mouse 507 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	120/496 (24%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	97/433 (22%)
Ugt1a2	NP_038729.1	UDPGT	28..524	CDD:278624	128/509 (25%)
		Glycosyltransferase_GTB_type	43..>175	CDD:299143	25/138 (18%)
		egt	<261..505	CDD:223071	79/249 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840634
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.690