DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt304A1 and ugt-16

DIOPT Version :9

Sequence 1:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_506210.1	Gene:	ugt-16 / 191171	WormBaseID:	WBGene00013901	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	548	Identity:	134/548 - (24%)
Similarity:	237/548 - (43%)	Gaps:	60/548 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PMF-WLISNSICWIRSSRILVIAPFESHSQCMLVTPYIQALKDRGHQLTV-----IHAYKHCMHK 68
            |:| :||...:|:  |.::||..|....|....:......|.|.|:.:|:     ::..|..:..
Worm     4 PIFLFLILVELCF--SYKVLVFNPAFGASHANFLGKISDILIDAGNDVTMLIPIFVNGKKELVGS 66

  Fly    69 IEDVTFIRIWYNNNVF-LEFEESVGIASANNKWE---EISSMSSLMANATLNVLNNVE------- 122
            .:....|||..:..:. :..|.|.........|:   .|:||...:.|.:.......|
Worm    67 KKVKKIIRIDQDPRIAQIHKEGSTEEIMRKTIWKMDSAITSMFGFIGNFSKTAAYQTEYMFQQTE 131

  Fly   123 -VRALMKSRITFDAVVLEAGYSDVLYGMAAHFSAQLIGICTCV-ADWNINNLVGFSTSTLTEP-- 183
             :..|.|.:  ||..:.|:    :..|..|.|..  |||.:.: ||..:  .:|.....|.||
Worm   132 LIEQLRKEK--FDLAITES----LFLGAFALFDE--IGIRSVINADSTL--YMGGMKGALGEPAA 186

  Fly   184 IMPFRAKYVK-----NVWDRIYNWL-YTTEEWLLI-----NLVFLPKQRLIHDHFFGHLEKSFHE 237
            |..:...:..     |.:.|:.|.: |....|..:     .:|..||.      :.|  .:.:.|
Worm   187 ISYYPGLFSSIDDKMNFFGRVKNAVGYLFGLWFSVLKYDDEIVAFPKS------YKG--SRDWRE 243

  Fly   238 IRQDFALMLLNQHFSLFRARPNVPGMVEVAGLHI--PKEDPQLPSDLQVFIDEAEHGVILFSLGL 300
            ...:.|...:|.:..:..|.|.:|..|.|.|:.:  .|......|.....:.......:|.|.|.
Worm   244 HLSNVAFNFINSNQYIDYASPTLPKTVFVGGMQVNTKKSGKSTLSKEWNDVLSLRKTNVLVSFGS 308

  Fly   301 EQDSKDLPRKTQEILVETFKSVPQRV-IWKFDGESTMSLGTDIYHSKL---LPQQAILAHPNVKL 361
            ...|.|:|.:.::..:|.|.|:|:.. |||:: .:..:|...:.:.||   :||..|||...:.|
Worm   309 NAYSSDMPDEFKKSFLEVFASMPETTFIWKYE-VANATLVDHLPNVKLTTWMPQNDILADDRLTL 372

  Fly   362 FISHCGMMSVIEAAYYAKPVLGLPSFFDQFRNLEIMKEEGVALELNINSLTVKE-LKDAIHSMIN 425
            ||:|.|:.|.:|.||..||.:.:|...||.||..::...|.||:|:...|...| |::||.:::|
Worm   373 FITHGGLGSSVELAYQGKPAVVIPLMADQPRNAHMLTRHGGALQLDKTWLNNSEKLREAIQTVLN 437

  Fly   426 EPEYRESALAISQRFRDQPIHPLDAAIYWTEYIIRYKGADHMKISQSQLKLFDYYSLDNFIMVGS 490
            :..|:.:|..:::...|||..|.|..:...::.:::...|.:......|..|.|||:|..:.:..
Worm   438 DVSYKHNAERLAKILEDQPHKPKDVVLKHCDFAVQFGPLDTLNSEGRLLNTFQYYSVDIVLAIFV 502

  Fly   491 RLSLVVALVFLVLSKSRRWLNHLSTSAK 518
            .||:::.:|:||:....|:|..|.:.:|
Worm   503 ILSVILFVVYLVIKLLFRFLGRLFSISK 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	121/508 (24%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	105/440 (24%)
ugt-16	NP_506210.1	UDPGT	19..532	CDD:278624	128/531 (24%)
		egt	<246..503	CDD:223071	71/257 (28%)
		HemY_N	483..>531	CDD:284604	15/48 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860