DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt304A1 and ugt-20

DIOPT Version :9

Sequence 1:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_500913.1	Gene:	ugt-20 / 187130	WormBaseID:	WBGene00019516	Length:	529	Species:	Caenorhabditis elegans

Alignment Length:	544	Identity:	116/544 - (21%)
Similarity:	225/544 - (41%)	Gaps:	91/544 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MFWLISNSICWIRSSRILVIAPFESHSQCMLVTPYIQALKDRGHQLTVI-----HAYKHCMHKIE 70
            :.:|:.::||:..|.:||.......||....:......|.|.||.:||:     .|.|..:...:
Worm     3 LLFLLFSAICFASSYKILFYTNLFGHSHVKFLGAAADTLTDAGHNVTVLIPVFDKALKTSLKSTK 67

  Fly    71 DVTFIR------------------IWYNNNVFLEFEESVGIASANNKWEEISSMSSLMANATLNV 117
            :|..::                  ||..:|           .:.....:::.:||.:.::....|
Worm    68 NVIMLQPTEDIANFVKGRATMLKNIWLQDN-----------TNPLTMIKKVETMSKIFSSQCKRV 121

  Fly   118 LNNVEVRALMKSRITFDAVVLEAGYSDVLYGMAAHFSAQLIGICTCVA-------DWNINNLVGF 175
            |:..::...:|:. .:|..:.|.      :...|:...:.|...|.||       | ::::::|
Worm   122 LSETDIIEKLKAE-NYDLAITEP------FDTCAYEFFEAIETRTHVAILSASRYD-HVSDVIG- 177

  Fly   176 STSTLTEPIMPFRAKYVKNVWDRIYNWLYTTEEWLLINLVFLPKQRLIHDHFFGHLE-------- 232
                     .|..|.|...:...  |....|....|:||:    |.....:||.::.
Worm   178 ---------QPAAASYNPGLLSS--NGDQMTMPQRLLNLI----QYAAGSYFFSYVGDKDAEVAK 227

  Fly   233 ------KSFHEIRQDFALMLLNQHFSLFRARPNVPGMVEVAGLHI--PKEDPQLPSDLQVFIDEA 289
                  :|:.|...:.:.::.||...|....|....::.:.||.:  .|:..:|.......:|..
Worm   228 EINPKWRSWRETLPEASFIMTNQIPLLDFPAPTFDKIIPIGGLSVKTDKKSLKLEEKWSKILDIR 292

  Fly   290 EHGVILFSLGLEQDSKDLPRKTQEILVETFKSVPQRV-IWKF-DGESTMSLGTD-IYHSKLLPQQ 351
            :..|.: |.|....|.|:|.:.::..::..||:|... |||: |.....:.|.: :|....|||.
Worm   293 KKNVFI-SFGSNARSVDMPLEYKKTFLQVIKSMPDTTFIWKYEDLNDKFTEGIENVYLGDWLPQN 356

  Fly   352 AILAHPNVKLFISHCGMMSVIEAAYYAKPVLGLPSFFDQFRNLEIMKEEGVALELNINSLT-VKE 415
            .:||...:.:|::|.|:.||.|.:....|.:.:|.|.||.||.:::|..|.|..|..|.|: .|.
Worm   357 ELLADKRLNVFVTHGGLGSVTELSMMGTPAVMIPLFADQSRNAQMLKRHGGAAVLVKNDLSNPKL 421

  Fly   416 LKDAIHSMINEPEYRESALAISQRFRDQPIHPLDAAIYWTEYIIRYKGADHMKISQSQLKLFDYY 480
            :::.|..:||..|||::|..:|:...:.|.:|.:..:.:.|:..|:.....:.....|....:|:
Worm   422 VQETIEKVINNSEYRKNAERLSEMLNNLPTNPRETLVKYVEFAARFGKLPSLDNYGRQQSFVEYF 486

  Fly   481 SLDNFIMVGSRLSLVVALVFLVLS 504
            .||..     .:.:::.|:||.:|
Worm   487 FLDII-----AIFILITLIFLYVS 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	109/518 (21%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	96/452 (21%)
ugt-20	NP_500913.1	UDPGT	29..518	CDD:278624	109/518 (21%)
ugt-20	NP_500913.1	egt	<268..500	CDD:223071	61/237 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860