DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt304A1 and ugt-8

DIOPT Version :9

Sequence 1:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_504315.1	Gene:	ugt-8 / 186768	WormBaseID:	WBGene00019234	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	554	Identity:	124/554 - (22%)
Similarity:	215/554 - (38%)	Gaps:	97/554 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLPMFWLISNSICWIRSSRILVIAPFESHSQCMLVTPYIQALKDRGHQLTVIHAYKHCMH----- 67
            ||.:..::.:..|    ..||:..|....|....::.....:.|.||.:|:...:...:.
Worm     6 LLSILLVLGSVSC----KNILIFNPIFGLSHVKFISKMANIIADHGHNVTLFQPFHIALKNTEGL 66

  Fly    68 --------------------KIEDVTFIRIW----YNNNVFLEFEESVGIASANNKWEEISSMSS 108
                                |.|..||...|    .||.|...|.....||....:
Worm    67 IKNKYIEIINYYPDHYDELLKTETATFPAFWDSHLMNNPVLSAFMIPKAIAGEFER--------- 122

  Fly   109 LMANATLNVLNNVEVRALMKSRITFDAVVLEAGYSDVLYGMAAHFSAQLIGICTCVADWN----- 168
               .||..:.:.|.:..| ||| .||.::.|.      :.:...:.|.::.: .|:..|:
Worm   123 ---TATQLLKDKVALDDL-KSR-NFDVIISET------FELTGMYIAHMLNV-PCIPVWSAVRFT 175

  Fly   169 -INNLVGFSTSTLTEPIMPF-----RAKYVKNVWDRIYNWLYTTEEWLLINLVFLPKQRLIHDHF 227
             .||:.| ..|:|.....||     .|.::..:.|...|:.:|         :.:.......:.|
Worm   176 IFNNIFG-QPSSLGYSQQPFSKLAPEAGFIDRLNDVYRNFFFT---------ITMDGMGQYQNDF 230

  Fly   228 FGHLEKS-------FHEIRQDFALMLLNQHFSLFRARPNVPGMVEVAGLHIPKE-----DPQLPS 280
               :||:       :.::.::..:...|.:..|..|.|....:|.:.|..:..|     || ||.
Worm   231 ---IEKAVGRPLPYWKDLIKEAPVYFTNSNEYLDFAVPTTATIVHIGGFTMDLEKMKHVDP-LPD 291

  Fly   281 DLQVFIDEAEHGVILFSLGLEQDSKDLPRKTQEILVETFKSVPQ-RVIWKF---DGESTMSLGTD 341
            .....::|.| ..:|.|.|....|..:|...:..:::.|:|:|. ..|||:   |.|....|..:
Worm   292 KYAKILEERE-STVLISFGSVIRSYQMPDNFKAGIIKMFESLPDVTFIWKYERDDVEFQKKLPKN 355

  Fly   342 IYHSKLLPQQAILAHPNVKLFISHCGMMSVIEAAYYAKPVLGLPSFFDQFRNLEIMKEEGVALEL 406
            ::..|.:||.::||...||||::|.|:.|.:|.||..||.|.:|.|.||..|..::...|.|:..
Worm   356 VHLKKWVPQHSLLADNRVKLFVTHGGLGSTMEVAYTGKPALMVPIFGDQPENANMLARHGGAISY 420

  Fly   407 NINSLTVKE-LKDAIHSMINEPEYRESALAISQRFRDQPIHPLDAAIYWTEYIIRYKGADHMKIS 470
            :...|...| |...|..|:..|:|.::|..:.:....|||.|....:...|:.:.:........:
Worm   421 DKFELADGEKLAITIRDMVRNPKYNKNAQELLKVLSHQPIDPKLNLMKHLEFAMEFPNLRSQVPA 485

  Fly   471 QSQLKLFDYYSLDNFIMVGSRLSLVVALVFLVLS 504
            .:|:.|..:|.||....:.....|.|.|.|.::|
Worm   486 INQMGLIAHYYLDVIFFLSLIFILTVYLTFKIIS 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	116/528 (22%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	103/459 (22%)
ugt-8	NP_504315.1	UDPGT	30..516	CDD:278624	116/521 (22%)
ugt-8	NP_504315.1	egt	<284..462	CDD:223071	56/179 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810