DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt304A1 and ugt-34

DIOPT Version :9

Sequence 1:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_505728.2	Gene:	ugt-34 / 185120	WormBaseID:	WBGene00009255	Length:	526	Species:	Caenorhabditis elegans

Alignment Length:	542	Identity:	121/542 - (22%)
Similarity:	227/542 - (41%)	Gaps:	82/542 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLPMFWLISNSICWIRSSRILVIAPFESHSQCMLVTPYIQALKDRGHQLT----VIHA----YKH 64
            |||...|         |...||..|..:||....:......|.:.||.:|    :||.    .|:
Worm    15 LLPQLTL---------SYNYLVFCPLFAHSHHKFLAKIADTLTEAGHNVTFLMPIIHREYENVKY 70

  Fly    65 CMHKIEDVTFIR----------------IWYNNNVFLEFEESVGIASANNKWEEISSMSSLMANA 113
            ..| ..|:.:|:                .|.|:...|.|     |.:....:...:.:..:: ..
Worm    71 LEH-TTDIVYIQPDKELEEIAQNADYSTFWKNDFGILTF-----IPAIERFFRMFTKVHDIL-KK 128

  Fly   114 TLNVLNNVEVRALMKSRITFDAVVLEAGYSDVLYGMAAHFSAQLIGICTCVADWNINNLVGFSTS 178
            .|:||:|::.|       .|||::.|:      ....||...:.:.|.|....|::.::...| .
Worm   129 DLSVLDNLKNR-------KFDAMIFES------LAFCAHPIREYLEIKTIFPSWSMTHMTELS-Q 179

  Fly   179 TLTEPIMP-FRAKYVKNVWDRIYNWLYTTEEWLLINL-------VFLPKQRLIHDHFFGHLEKSF 235
            .:.||..| |....:....|::     |.:|.||..|       :|.|.  .:....:.|....|
Worm   180 AIGEPSSPTFLPITISPFGDKM-----TFKERLLNTLADFTFTHIFQPP--TLTSFKYPHQTFDF 237

  Fly   236 HEIRQDFALMLLNQHFSLFRARPNVPGMVEVAGLHIP---KEDPQLPSDLQVFIDEAEHGVILFS 297
            .||......:..|.:..|...||.:...:|:.|:.:.   ....:||.:....::..:..| |.|
Worm   238 KEILSQAPFIFFNSNPFLDFPRPTLTKTIEIGGISVNATLMRLEKLPEEYNTILNLKQQNV-LIS 301

  Fly   298 LGLEQDSKDLPRKTQEILVETFKSVPQ-RVIWKFDG---ESTMSLGTDIYHSKLLPQQAILAHPN 358
            .|....|.::|.:.::.:.:..:|.|. ..|||::.   |...:| .:.:..|.:||.|:||...
Worm   302 FGSMLRSSEMPVEYKDTIAQVVRSFPSVTFIWKYENNNVEFAENL-PNFHFFKWVPQTALLADSR 365

  Fly   359 VKLFISHCGMMSVIEAAYYAKPVLGLPSFFDQFRNLEIMKEEGVALELNINSL-TVKELKDAIHS 422
            :..||:|.|:.|:.|.:|..||.:.:|.|.||.||.:::.....::||:...| ....|:||:.:
Worm   366 LSAFITHAGLGSINELSYIGKPAILVPIFADQLRNAKMLVRHNGSIELDKKDLGKFDVLRDAVDA 430

  Fly   423 MINEPEYRESALAISQRFRDQPIHPLDAAIYWTEYIIRYKGADHMKISQSQLKLFDYYSLDNFIM 487
            ::|:..|..:|:.:||:...||..|.|..:.:.|:..::.....:.....::..|.::.:|..:.
Worm   431 ILNDKSYTNNAILLSQQLESQPFSPHDLLVKYAEFGAKFGELPSLDPHYRKMSFFSFFMIDIILF 495

  Fly   488 VGSRLSLVVAL---VFLVLSKS 506
            :.:..::.|::   :|.|..||
Worm   496 LTATFAIFVSISLYLFRVFFKS 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	115/511 (23%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	100/442 (23%)
ugt-34	NP_505728.2	UDPGT	35..518	CDD:278624	112/513 (22%)
ugt-34	NP_505728.2	Glycosyltransferase_GTB_type	<248..500	CDD:299143	60/253 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810