DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt304A1 and ugt-48

DIOPT Version :9

Sequence 1:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_504464.2	Gene:	ugt-48 / 178940	WormBaseID:	WBGene00015965	Length:	526	Species:	Caenorhabditis elegans

Alignment Length:	557	Identity:	138/557 - (24%)
Similarity:	235/557 - (42%)	Gaps:	98/557 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SICWIRSS-RILVIAPFESHSQCMLVTPYIQALKDRGHQLTVIHA-YKHCMHKIEDVTFIRIW-- 78
            ::|.:.:| :||:.:|..|.|..:........|.:.||::..... :.:...|.......|.|
Worm    10 AVCQVTTSHKILMFSPTASKSHMISQGRIADELANAGHEVVNFEPDFLNLTDKFVPCKKCRRWPV 74

  Fly    79 --YNNNVFLEFEESVG--IASANNKWEEISSMSS-----LMANATLNVLNNVE-VRALMKSRITF 133
              .||..|.:.:..:.  :...::.|.:|.:..|     ...|....::.|.| :..|.|.:  |
Worm    75 TGLNNYKFKKIQNGLSGDVFQQSSIWSKIFNTDSDPYQDEYTNMCEEMVTNKELIEKLKKEK--F 137

  Fly   134 DAVVLEAGYSDVLYGMAAHFSAQLIG------ICTCVADWNINNLVGFST--------STLTEPI 184
            ||..   |....|.||..   |.|||      |.:|....::.:.:|..|        |||....
Worm   138 DAYF---GEQIHLCGMGL---AHLIGIKHRFWIASCTMSVSMRDSLGIPTPSSLIPFMSTLDATP 196

  Fly   185 MPFRAKYVKNVWDRIYNWL----YTTEEW---LLINLVFLPKQRLIHDHFFGHLEKSFHEIRQDF 242
            .||        |.|..|::    :..:|:   :|.|.:|               :|:|   ..||
Worm   197 APF--------WQRAKNFVLQMAHIRDEYRDVVLTNDMF---------------KKNF---GSDF 235

  Fly   243 A----------LMLLNQHFSLFRARPNVPGMVEVAGLHIPKEDPQLPSDLQVFIDEAEHGVILFS 297
            .          |:.::....|....|.:..:|.:.||.:..|...|.... |.|.|...||||||
Worm   236 PCVEFLAKTSDLIFVSTDELLEIQAPTLSNVVHIGGLGLSSEGGGLDEKF-VKIMEKGKGVILFS 299

  Fly   298 LGLEQDSKDLPRKTQEILV---ETFKSVPQRV-IWKFDGES-TMSLG-TDIYHSKLLPQQAILAH 356
            ||...::.:||....|.|:   :.||.....: :.|||..| .::.| :::.....:||.|:|||
Worm   300 LGTIANTTNLPPTIMENLMKITQKFKDYEFIIKVDKFDRRSFDLAEGLSNVLVVDWVPQTAVLAH 364

  Fly   357 PNVKLFISHCGMMSVIEAAYYAKPVLGLPSFFDQFRNLEIMKEEGVALELNINSLTVKELKDAIH 421
            |.:|.||:|.|..|::|:||...||:.:|..|||.||...::.:|..: |......:|: .|||.
Worm   365 PRLKAFITHAGYNSLMESAYAGVPVILIPFMFDQPRNGRSVERKGWGI-LRDRFQLIKD-PDAIE 427

  Fly   422 SMINE----PEYRESALAISQRFRDQPIHPLDAAIYWTEYIIRYKGADHMKISQSQLKLFDYYSL 482
            ..|.|    |.|:|.|..:.:..|.:|....:..:..|.:::...|.:.::.....:..|.:|:|
Worm   428 GAIKEILVNPTYQEKANRLKKLMRSKPQSASERLVKMTNWVLENDGVEELQYEGKHMDFFTFYNL 492

  Fly   483 DNFIMVGSRLSLVVALVFLVLSKSRRWLNHLSTSAKS 519
            |..|...|    :..|:|:||..|.  ::.:::|.|:
Worm   493 DIIITAAS----IPVLIFIVLRISN--ISIITSSPKN 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	126/516 (24%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	115/456 (25%)
ugt-48	NP_504464.2	UDPGT	19..510	CDD:278624	132/531 (25%)
ugt-48	NP_504464.2	egt	<224..471	CDD:223071	75/267 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.710