DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt304A1 and ugt-53

DIOPT Version :9

Sequence 1:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_503771.1	Gene:	ugt-53 / 178744	WormBaseID:	WBGene00020182	Length:	515	Species:	Caenorhabditis elegans

Alignment Length:	575	Identity:	142/575 - (24%)
Similarity:	234/575 - (40%)	Gaps:	123/575 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RWLLPMFWLISNSICWIRSSRILVIAPFESHSQCMLVTPYIQALKDRGHQLTVIHAYKHCMHKIE 70
            |.|:.:..||:.|.|........||.|  ||...:..|  |..|..|||.:.|:.|..:.:..::
Worm     2 RLLIFLTVLINFSSCLNILFYYAVIGP--SHIAYLRNT--IGKLLARGHNVDVVFAVYNELANLD 62

  Fly    71 ---DVTFIRIWYNNNVFLEFEESVGIASANNKWEEISSMSSLMANATLNVLNNVEVRALMKSRIT 132
               ||.  ||:||.:...::            |::.::..|.|...:...|...|
Worm    63 LFPDVR--RIYYNRHADPDY------------WKKNANHFSNMFEKSPTPLGEFE---------- 103

  Fly   133 FDAVVLEAGYSDVLYGMAAHFSAQLIGICTCVADWNINNL------------VGFST-------- 177
               :..|:||             ||..|.       ||:|            :|||:
Worm   104 ---IFHESGY-------------QLCKIA-------INDLKLIEFLKSGKYDIGFSSDYDPCGNI 145

  Fly   178 -----------STLTEPI---------MPFRA---------KYVKNVWDRIYNWLYTTEEWLLIN 213
                       |.:..||         :|..|         ::..:::|:|:|.:..|.....|:
Worm   146 LMTAAGIPSIGSLIATPIFLPHIVSAGLPTVASVYGTSLYPEHDSSLYDKIFNLIRLTYYHYAIS 210

  Fly   214 LVFLPKQRLIHDHFFGHLEKSFHEIRQDFALMLLNQHFSLFRARPNVPGMVEVAGLHIPKEDPQL 278
            .....|...:....||:.......|.:...::.:|.|..|.:.||..|.:..:.|:.|.|. .||
Worm   211 PDMDRKYNNLITKRFGNNFPDVGTIERGIDIIFVNSHDFLEQQRPMSPKIKYIGGMAIRKA-KQL 274

  Fly   279 PSDLQVFIDEAEHGVILFSLGLEQDSKDLPRKTQEILVETFKSVPQ-RVIWKFDGESTMSLGTDI 342
            |.:.:..:...:...:|||.|.:..:..:|...:...|..||..|. ..:||:|   ::.|..||
Worm   275 PDEFEKILSVPKSAYVLFSFGTQVPTAKMPLPIRRNFVGAFKKFPNVTFLWKYD---SLELDADI 336

  Fly   343 YHS-------KLLPQQAILAHPNVKLFISHCGMMSVIEAAYYAKPVLGLPSFFDQFRNLEIMKEE 400
            :..       :.|||..:|....|||||||.|:.|.:|.|....|||.:|.|.||..|.:..::.
Worm   337 FQGVENIHRLEWLPQTELLHDNRVKLFISHMGLNSYLETATAGVPVLSIPLFADQQNNAQNTRDR 401

  Fly   401 GVALELNINSLTVKELKDAIHSMINEPEYRESALAISQRFRDQPIHPLDAAIYWTEYIIRYKGAD 465
            |:.|.|:.:.||.|.::.|:|.::..|:|..:|.:||:...::|....|..|:|.|:..|..|..
Worm   402 GMGLLLDRDKLTTKNIESALHELLENPKYLSNARSISKMILEKPDKANDTFIHWLEFTARNPGLG 466

  Fly   466 H-MKISQSQLKLFDYYSLDNFIMVGSRLSLVVALVFLVLSKSRRWLNHLSTSAKS 519
            . :|:..::|..|.||       .|..|.||..::|::|....|.:|..|...||
Worm   467 RVLKLPGAELSPFYYY-------CGDILLLVFCILFIILHTVLRTINLPSRKIKS 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	128/532 (24%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	108/462 (23%)
ugt-53	NP_503771.1	UDPGT	29..497	CDD:330975	127/527 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.710