Protein Alignment Ugt304A1 and UGT3A2

DIOPT Version :10

• Sequence 1: NP_652619.1
• Gene: Ugt304A1 / 53501
• FlyBaseID: FBgn0040250
• Length: 529
• Species: Drosophila melanogaster
• Sequence 2: XP_011512290.1
• Gene: UGT3A2 / 167127
• HGNCID: 27266
• Length: 550
• Species: Homo sapiens
• Alignment Length: 577
• Identity: 127/577 - (22%)
• Similarity: 243/577 - (42%)
• Gaps: 109/577 - (18%)

  Fly     5 GRWLLPMFWLISNSICWIRSSRILVIAPFESHSQCMLVTPYIQALKDRGHQLT------------ 57
            |:.:|.:...:...:....:::||.|:.. ..|..:|:....|.|:|.||.:|
Human     3 GQRVLLLVGFLLPGVLLSEAAKILTISTV-GGSHYLLMDRVSQILQDHGHNVTMLNHKRGPFMPG 66

  Fly    58 -------------VIHAYKHCMHKIEDVT------FIRIW---------YNNNVFLEFEESVGIA 94
                         :::..|:|...::|..      .:..|         :..:.....||::|
Human    67 LSDSPASASRYPRILYLQKYCQFGLKDFKKEEKSYQVISWLAPEDHQREFKKSFDFFLEETLG-- 129

  Fly    95 SANNKWEEISSMSSLMANATLNVLNNVEVRALMKSRITFDAVVLEA-GYSDVLYGMAAHFSAQLI 158
             ...|:|.:.::...:|....:.||..::...:|:. .||.|::|. .|...|  :|.......:
Human   130 -GRGKFENLLNVLEYLALQCSHFLNRKDIMDSLKNE-NFDMVIVETFDYCPFL--IAEKLGKPFV 190

  Fly   159 GICTCVADWNINNLVGFSTSTLTEPI----MP-FRAKYVKNV--WDRIYNWLYTTEEWLLINLVF 216
            .|.:          ..|.:.....||    :| ||:....::  |.|:.|:        |:...|
Human   191 AILS----------TSFGSLEFGLPIPLSYVPVFRSLLTDHMDFWGRVKNF--------LMFFSF 237

  Fly   217 LPKQRLIHDHFFGHLEKSF-HEIRQDFA---------------LMLLNQHFSLFRARPNVPGMVE 265
            ..:|:        |::.:| :.|::.|.               |..:|..|:...|||.:|..|.
Human   238 CRRQQ--------HMQSTFDNTIKEHFTEGSRPVLSHLLLKAELWFINSDFAFDFARPLLPNTVY 294

  Fly   266 VAGLHIPKEDPQLPSDLQVFIDE-AEHGVILFSLGLEQDSKDLPRKTQEILVETFKSVPQRVIWK 329
            |.|| :.|....:|.||:.||.: .:.|.:|.:||...::...|...:| :...|..:||.||||
Human   295 VGGL-MEKPIKPVPQDLENFIAKFGDSGFVLVTLGSMVNTCQNPEIFKE-MNNAFAHLPQGVIWK 357

  Fly   330 FD---GESTMSLGTDIYHSKLLPQQAILAHPNVKLFISHCGMMSVIEAAYYAKPVLGLPSFFDQF 391
            ..   ....:.|..::.....|||..:||||:::||::|.|..|::||..:..|::|:|.|.||.
Human   358 CQCSHWPKDVHLAANVKIVDWLPQSDLLAHPSIRLFVTHGGQNSIMEAIQHGVPMVGIPLFGDQP 422

  Fly   392 RNLEIMKEEGVALELNINSLTVKELKDAIHSMINEPEYRESALAISQRFRDQPIHPLDAAIYWTE 456
            .|:..::.:...:.:.:..|..:.|...:..::.:..|:.:|:|.|...|..|:.|....:.|.:
Human   423 ENMVRVEAKKFGVSIQLKKLKAETLALKMKQIMEDKRYKSAAVAASVILRSHPLSPTQRLVGWID 487

  Fly   457 YIIRYKGADHMKISQSQLKLFDYYSLDNFIMVGSRLSLVVALVFL---VLSKSRRWL 510
            ::::..||.|:|....|....:.|.||.|:.:   |.|.:..::|   :|..:..||
Human   488 HVLQTGGATHLKPYVFQQPWHEQYLLDVFVFL---LGLTLGTLWLCGKLLGMAVWWL 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	GT1_Gtf-like	26..454	CDD:340817	109/495 (22%)
UGT3A2	XP_011512290.1	Glycosyltransferase_GTB-type	23..518	CDD:471961	119/529 (22%)