DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt304A1 and Ugt2b37

DIOPT Version :9

Sequence 1:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_444445.2	Gene:	Ugt2b37 / 112417	MGIID:	2148239	Length:	530	Species:	Mus musculus

Alignment Length:	564	Identity:	144/564 - (25%)
Similarity:	248/564 - (43%)	Gaps:	119/564 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PGRWLLPMFWLISNSICW--IRSSRILVIAPFESHSQCMLVTPYIQALKDRGHQLTVIH--AYKH 64
            ||:|:..:. |:..|.|:  ::..::|| .|.| .|..|.:...:..|..|||::||:.  ||
Mouse     2 PGKWISALL-LLQISCCFRSVKCGKVLV-WPME-FSHWMNIKIILDELVQRGHEVTVLRPSAY-- 61

  Fly    65 CMHKIEDVTFIRIWYNNNVFLEFEESVGIASANNKWEEI--SSMSSLMANATLNVLNNVEVRALM 127
                              ..|:.::|.|:     |:|..  |.....:.|..:.:||   |....
Mouse    62 ------------------YVLDPKKSPGL-----KFETFPTSVTKDDLENFFIQLLN---VWTYE 100

  Fly   128 KSRITFDAVVLEAGYSDVLYGMAAHFSAQLIGICTCVA--------------DWNINNLVGFSTS 178
            .||.|.      ..||.::..|....|...:.:|..|.              |..:::.|.|...
Mouse   101 LSRDTC------LSYSPLMQNMFDELSGYYLSLCKDVVSNRQLMTKLQESKFDVLLSDPVAFGGE 159

  Fly   179 TLTEPI-------MPFRAKY--------------------------------VKNVWDRIYNWLY 204
            .:.|.:       :.|.|.|                                |||:...:|
Mouse   160 LIAELLHIPFLYSLRFTAGYRIEKSSGRFLLPPSYVPVILSGLGGQMTFIERVKNMICMLY---- 220

  Fly   205 TTEEWLLINLVFLPKQRLIHDHFFGHLEK--SFHEIRQDFALMLLNQHFSLFRARPNVPGMVEVA 267
             .:.|..     :|..:.....:..:|.:  :..|......:.|:..::.|....|.:|.:..|.
Mouse   221 -FDFWFQ-----MPNDKKWDSFYTEYLGRPTTLAETMGQAEMWLIRSNWDLEFPHPTLPNVDYVG 279

  Fly   268 GLHIPKEDPQLPSDLQVFIDEA-EHGVILFSLGLEQDSKDLPRKTQEILVETFKSVPQRVIWKFD 331
            |||.....| ||.|::.::..: :|||::||||  ....::..:....:......:||:|:||||
Mouse   280 GLHCKPAKP-LPKDMEEYVQSSGDHGVVVFSLG--SMVSNITEEKVNAIAWALAQIPQKVLWKFD 341

  Fly   332 GESTMSLG--TDIYHSKLLPQQAILAHPNVKLFISHCGMMSVIEAAYYAKPVLGLPSFFDQFRNL 394
            |::..:||  |.:|  |.|||..:|.||..|.||:|.|..||.||.|:..|::|:|.|.:|..|:
Mouse   342 GKTPATLGHNTRVY--KWLPQNDLLGHPKTKAFITHGGANSVYEAIYHGIPMIGIPLFGEQHDNI 404

  Fly   395 EIMKEEGVALELNINSLTVKELKDAIHSMINEPEYRESALAISQRFRDQPIHPLDAAIYWTEYII 459
            ..|..:|.|:.|||.:::..::.:|:..:|..|.|:::|:.:|....|||:.|||.|::|.|:::
Mouse   405 AHMVAKGAAVTLNIRTMSRSDVLNALEEVIENPFYKKNAMWLSTIHHDQPMKPLDRAVFWVEFVM 469

  Fly   460 RYKGADHMKISQSQLKLFDYYSLDNFIMVGSRLSLVVALVFLVL 503
            |:|.|.|::.....|..:.|:|||   ::|..|:.|.|.|.|.:
Mouse   470 RHKNAKHLRPLGHNLTWYQYHSLD---VIGFLLACVAATVVLTV 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	131/535 (24%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	110/464 (24%)
Ugt2b37	NP_444445.2	UDPGT	24..527	CDD:278624	138/541 (26%)
		Glycosyltransferase_GTB_type	42..>174	CDD:299143	31/165 (19%)
		egt	<270..489	CDD:223071	78/223 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840468
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.690