DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt304A1 and ugt5f1

DIOPT Version :9

Sequence 1:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	XP_017207383.1	Gene:	ugt5f1 / 100415800	ZFINID:	ZDB-GENE-100406-6	Length:	556	Species:	Danio rerio

Alignment Length:	519	Identity:	141/519 - (27%)
Similarity:	246/519 - (47%)	Gaps:	65/519 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 IRSSRILVIAPFESHSQCMLVTPYIQALKDRGHQLTVIHAY---------KHCMHKIEDVTFI-- 75
            :...:|||. |.|. |..:.:...|:.|..||||::||.|.         .|  :...:|.|:
Zfish    49 VHCGKILVF-PHEG-SHWLNLNTLIEELHHRGHQISVIRALDSWYIPETSPH--YDSINVPFLLG 109

  Fly    76 --RIWYNNNVFLEFEESVGIASANNKW----------EEISSMSSLMANATLNVLNNVEVRALMK 128
              ..:|::.:|.:.:     .....:|          |:.|.|...:....::::.  :..|:||
Zfish   110 GDDQFYHSFIFRQLQ-----IRREQRWTRFKLDMELKEKFSEMHRKICEMVIHIVE--KEPAIMK 167

  Fly   129 --SRITFDAVVLE-AGYSDVLYGMAAH----FSAQLIGICTCVADWNINNLVGFSTSTLTEPIMP 186
              ....||.::.: |....|:.....|    |:.|          |.::....|:.:......:|
Zfish   168 QIKEANFDIMLTDPANGGGVVLAHYLHLPLVFNVQ----------WTVHGEAHFAIAPSPPSYVP 222

  Fly   187 FRAKYVKNVW---DRIYNWLYTTEEWLLINLVFLPKQRLIHDHFFGHLEKSFHEIRQDFALMLLN 248
            |....:.:..   .||||.|::.....|......|....:.:..||. ...:.|:.|...:.|:.
Zfish   223 FPLSQLTDSMSFPQRIYNVLFSAVRLFLYRRTVGPHYSALCNRLFGP-GLDYFELFQAADIWLMR 286

  Fly   249 QHFSLFRARPNVPGMVEVAGLHI-PKEDPQLPSDLQVFIDEA-EHGVILFSLG--LEQDSKDLPR 309
            ..|.....||.:|.::.:.|.|. |.:  .||.||:.|:..: |||||:.|||  :.|    ||.
Zfish   287 ADFVFDFPRPTMPNVIYIGGFHCSPAK--ALPKDLEDFLQSSGEHGVIVMSLGTLVAQ----LPM 345

  Fly   310 KTQEILVETFKSVPQRVIWKFDGESTMSLGTDIYHSKLLPQQAILAHPNVKLFISHCGMMSVIEA 374
            ...:.:|..|..:||:|||::.|:...::|.:......|||..:|.||..::|:||.|...|.||
Zfish   346 DIADEIVAAFAELPQKVIWRYTGDRPANVGNNTLLVNWLPQNDLLGHPKTRVFVSHGGTNGVFEA 410

  Fly   375 AYYAKPVLGLPSFFDQFRNLEIMKEEGVALELNINSLTVKELKDAIHSMINEPEYRESALAISQR 439
            .|:..|::|||..|||..||..||.:|||..|:|.::.....|||:..::|:|.||.:...:|..
Zfish   411 IYHGVPIVGLPLVFDQDYNLLKMKHKGVAKVLDIATINRNIFKDALQEVLNDPSYRSNMQKLSSL 475

  Fly   440 FRDQPIHPLDAAIYWTEYIIRYKGADHMKISQSQLKLFDYYSLDNFIMVGSRLSLVVALVFLVL 503
            .:|.|:.|||:|::|||:::|::||.|::....::..:.|:|:|..:.:.|.|..:|.|:|.::
Zfish   476 HKDTPLKPLDSALFWTEFVMRHRGAAHLRTDSYKMPWYSYHSVDVGVFLVSVLCFIVFLMFKIV 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	133/494 (27%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	115/439 (26%)
ugt5f1	XP_017207383.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584529
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.790