DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt304A1 and ugt2a3

DIOPT Version :9

Sequence 1:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001170814.2	Gene:	ugt2a3 / 100384900	ZFINID:	ZDB-GENE-080721-22	Length:	532	Species:	Danio rerio

Alignment Length:	549	Identity:	151/549 - (27%)
Similarity:	244/549 - (44%)	Gaps:	105/549 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLPMFWLISNSICWIRSSRILVIAPFESHSQCMLVTPYIQALKDRGHQLTVI------------- 59
            ||....|....:.|  |.|:||:....||...|  ...|:||.||.|.:||:
Zfish     6 LLVCLLLCGVDVGW--SGRVLVMPGEYSHWHNM--RAIIEALVDRNHSVTVLVGSSSPTVPHTQK 66

  Fly    60 -----HAYKHCMHKIE-DVT---FIRIWYNNNVFLEFEESVGIASANNKWEEISSMSSLMANATL 115
                 |.:|..:.|.| |..   ||.:|.|...              .|:|.:|::..:|:.  .
Zfish    67 ARFDYHVFKVNIEKEEADAVWSDFIYLWMNETA--------------TKYETVSNIFQVMSR--F 115

  Fly   116 NVLNNVEVRALMKSRITFDAVVLEAGYSDVLYG---------MAAHFSAQLIGICTCVADWNINN 171
            ..|.:...:.:.|..:   ..:|...:.|||:.         ||...:..|:........::...
Zfish   116 MTLTDEVCKGMFKEDL---LQMLRESHYDVLFSDPMMPCSDLMAQTLNIPLVLSLRATFAYSFER 177

  Fly   172 LVGFSTSTLTEPIMPFRAKYV------KNVWDRIYNWLYTTEEWLLINLVFLPKQRLIHDHFFG- 229
            :.|         .||....||      .::.||: :::...|..||.         ..||.||.
Zfish   178 MCG---------QMPAPPSYVPAASLRDHLTDRM-SFMERVENMLLY---------FSHDVFFKL 223

  Fly   230 ----HLEKSFHEIRQDFALM----------LLNQHFSLFRARPNVPGMVEVAGLHIPKEDPQLPS 280
                ..::.:.|||.....|          |:..::.....||..|....|.|||.....| |..
Zfish   224 YMMFTFDRIYTEIRGKPTTMCETMGKADIWLIRTYWDFEYPRPFPPNFKFVGGLHCKPAKP-LSK 287

  Fly   281 DLQVFIDEA-EHGVILFSLGLEQDSKDLPRKTQEILVETFKSVPQRVIWKFDGES--TMSLGTDI 342
            :::.|:..: :|||::||||  ...|:|..:....:......:||:|:|::.|::  |::..|.|
Zfish   288 EMEEFVQSSGDHGVVVFSLG--SMIKNLTSERANTIAAALGQIPQKVVWRYSGKTPETLAPNTKI 350

  Fly   343 YHSKLLPQQAILAHPNVKLFISHCGMMSVIEAAYYAKPVLGLPSFFDQFRNLEIMKEEGVALELN 407
            |  ..:||..:|.||..|.||:|.|...:.||.|:..|::|||.|.||..||..||.:|.|:.|:
Zfish   351 Y--DWIPQNDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVVLD 413

  Fly   408 INSLTVKELKDAIHSMINEPEYRESALAISQRFRDQPIHPLDAAIYWTEYIIRYKGADHMKISQS 472
            ||:|..|:|.||:.:::|.|.|:||.:.:|:...|||:.|||.|:||.|:::|.|||.|:::...
Zfish   414 INTLESKDLVDALKTVLNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAH 478

  Fly   473 QLKLFDYYSLDNFIMVGSRLSLVVALVFL 501
            :|..:.|:.||   :....||:...:.||
Zfish   479 ELSWYQYHCLD---VAAFLLSIAALITFL 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	144/526 (27%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	119/457 (26%)
ugt2a3	NP_001170814.2	UDPGT	21..519	CDD:278624	146/532 (27%)
		REC	<129..>178	CDD:302758	7/51 (14%)
		egt	<254..485	CDD:223071	85/235 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585030
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.930