DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SP1029 and NPEPPS

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	XP_016880861.1	Gene:	NPEPPS / 9520	HGNCID:	7900	Length:	924	Species:	Homo sapiens

Alignment Length:	938	Identity:	294/938 - (31%)
Similarity:	468/938 - (49%)	Gaps:	85/938 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LGLATADSSADSIETTYNYYRLPTSLRPQKYHLRILTLLENPE--DLRFSGSVKILIEALENTKN 75
            ||||.......       :.|||..:.|..|.|.:     .|:  |..|.|.::...:..:.|..
Human    40 LGLAAMPEKRP-------FERLPADVSPINYSLCL-----KPDLLDFTFEGKLEAAAQVRQATNQ 92

  Fly    76 VTLHSKNLTIDESQITLRQIGGEGKKENCVSSTAVN-PSHDFYILNTCQELLAGNTYELYMPFAA 139
            :.::..::.|    || .....||.:|  :.:|..| .:.|..:..:....|...|..|.:.|..
Human    93 IVMNCADIDI----IT-ASYAPEGDEE--IHATGFNYQNEDEKVTLSFPSTLQTGTGTLKIDFVG 150

  Fly   140 DLNRQLEGYYRSSYKDPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAIS 204
            :||.:::|:|||.|..|...: ::.:|||||...||.||||:|||..||.|.::|...|...|:|
Human   151 ELNDKMKGFYRSKYTTPSGEV-RYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALS 214

  Fly   205 NMPEKETKPHETLADYIWCEFQESVPMSTYLVAYSVNDFSHKPSTLPNSALFRTWARPNAIDQCD 269
            ||...:.||:....:.:..:|..:..|||||||:.|.::....:...:....|.:......:|..
Human   215 NMNVIDRKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGK 279

  Fly   270 YAAQFGPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAHSSLADKQ 334
            :|.:...|.|.:|:.:|.:.:||||||.||:.||:||||||||||||||.|||....:|..:.:|
Human   280 FALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQ 344

  Fly   335 RVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWRSMEQESLSNLLTIFR 399
            .||.||.||||||||||||||:|||.||||||||:::..|.|::..||:....|...::......
Human   345 WVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQE 409

  Fly   400 RDALESSHPISRPIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQKFSYKNAE 464
            .|||::||||...:...||:.|.||.|||.||::|:||:|.::|::.|:.|:..||.||..|||.
Human   410 LDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAA 474

  Fly   465 QDNLWESLTQAAHKYRSLPKSYDIKSIMDSWTLQTGYPVINVTRDYAA--RTAKLNQERYLLNTQ 527
            .::|||||..|:.|        .|.::|::||.|.|:|:|.|..:...  |..:|:|:::.
Human   475 TEDLWESLENASGK--------PIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQKKFC---- 527

  Fly   528 VARAYRG-GC--WWVPLSYTTQAVQDFNNTAPKAWMECGKNGESLPKTIQDLPGPDQWVIFNTQL 589
            ...:|.| .|  |.||::.:|.  :|.|....|..|:..:....| |.::    |||||..|...
Human   528 AGGSYVGEDCPQWMVPITISTS--EDPNQAKLKILMDKPEMNVVL-KNVK----PDQWVKLNLGT 585

  Fly   590 STLYKVNYDAQNWKLLIETLTNG--DFERIHVINRAQLIDDALYLAWTGEQDYEIAMRLIEYLQR 652
            ...|:..|.:    .::|:|..|  |.. :..::|..|.:|...||..|.......::::|....
Human   586 VGFYRTQYSS----AMLESLLPGIRDLS-LPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVN 645

  Fly   653 EREYLPWKSAFENLKRVGRIVRQTPDFEFFKRYMKKLILPIYEHLNGINDTFSAIPQQDQV--LL 715
            |..|..|.....||..:..::..|..:|..:.::|.:..||.|.|.     :...|.:..:  ||
Human   646 EPNYTVWSDLSCNLGILSTLLSHTDFYEEIQEFVKDVFSPIGERLG-----WDPKPGEGHLDALL 705

  Fly   716 KTMVVNWACQYQVGDCVPQALAYYRNWRAEANPDEKNPVPINVRSTVYCTSIKHGSDSDWEFLWT 780
            :.:|:.     ::|....:|.......|.:.:.:.|..:..::||.||.|.:|||..:..:.:..
Human   706 RGLVLG-----KLGKAGHKATLEEARRRFKDHVEGKQILSADLRSPVYLTVLKHGDGTTLDIMLK 765

  Fly   781 RYKKSNVAAEKRTILTALGCSREVWLLQRYLELTFDPKEAIRKQDSMWAFQAVA-FNEVGFLLAK 844
            .:|::::..||..|...||.:....|:|:.  |||...|.:|.||::.....|| .::.|...|.
Human   766 LHKQADMQEEKNRIERVLGATLLPDLIQKV--LTFALSEEVRPQDTVSVIGGVAGGSKHGRKAAW 828

  Fly   845 KYFMDNVDFIYKFYHP--LTKDMSRLLSP--LSEQVITLSDFNEFKD-FVNNSRQSLKGLEQAIQ 904
            |:..||.:.:|..|..  |   :|||:..  |:..:..|.|....:. .|.:||.|.    ....
Human   829 KFIKDNWEELYNRYQGGFL---ISRLIKVQWLTPVIPALWDAEVGRSPEVGSSRLSW----PTCY 886

  Fly   905 QTLEIMLTNVQWKERNYHQMSRSIQQLL 932
            |..::.|  ::|.||  .::|..:.|||
Human   887 QLRDLQL--IKWLER--LRLSSRVTQLL 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	151/400 (38%)
		M1_APN_2	43..502	CDD:189008	176/461 (38%)
		ERAP1_C	583..908	CDD:288671	79/334 (24%)
NPEPPS	XP_016880861.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820