Protein Alignment SP1029 and AAP1

DIOPT Version :10

• Sequence 1: NP_652618.1
• Gene: SP1029 / 53473
• FlyBaseID: FBgn0263236
• Length: 932
• Species: Drosophila melanogaster
• Sequence 2: NP_011913.1
• Gene: AAP1 / 856443
• SGDID: S000001089
• Length: 856
• Species: Saccharomyces cerevisiae
• Alignment Length: 936
• Identity: 294/936 - (31%)
• Similarity: 438/936 - (46%)
• Gaps: 149/936 - (15%)

  Fly    34 LPTSLRPQKYHLRILTLLENPEDLRFSGSVKILIEALENTKNVTLHSKNLTIDESQITLRQIGG- 97
            ||.::.|..|.   :||..|.....|.||:||.::..:::.| ::....|.||.....:..:..
Yeast     6 LPNNVTPLHYD---ITLEPNFRAFTFEGSLKIDLQINDHSIN-SVQINYLEIDFHSARIEGVNAI 66

  Fly    98 -EGKKENCVSSTAVNPSHDFYILNTCQELLAGNTYELYMPFAADLNRQLEGYYRSSYKDPVANLT 161
             ..|.||...:|.|.|:..|..|        |.:.:|.:.|:..||.|:.|:||:.|.|.|...|
Yeast    67 EVNKNENQQKATLVFPNGTFENL--------GPSAKLEIIFSGILNDQMAGFYRAKYTDKVTGET 123

  Fly   162 KWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAISNMPE-----KETKPHETLADYI 221
            |:::.||.|...||.||||||||:.||.|.|||......|.:|||..     ||.|.:.|
Yeast   124 KYMATTQMEATDARRAFPCFDEPNLKATFAVTLVSESFLTHLSNMDVRNETIKEGKKYTT----- 183

  Fly   222 WCEFQESVPMSTYLVAYSVNDFSHKPST---LPNSALFRTWARPNAIDQCDYAAQFGPKVLQYYE 283
               |..:..|||||||:.|.|..:..|.   :|    .|.::.|.......:||....:.|:::|
Yeast   184 ---FNTTPKMSTYLVAFIVADLRYVESNNFRIP----VRVYSTPGDEKFGQFAANLAARTLRFFE 241

  Fly   284 QFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAHSSLADKQRVASVVAHELAHQW 348
            ..|.|::||||:|.:||.:|||||||||||||||.|.||....:|||...||||.|:.|||||||
Yeast   242 DTFNIEYPLPKMDMVAVHEFSAGAMENWGLVTYRVIDLLLDIENSSLDRIQRVAEVIQHELAHQW 306

  Fly   349 FGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWRSMEQESLSNLLTIFRRDALESSHPISRPI 413
            |||||||.||..|||||||||:::........|||:..||....||......|:|.|||||..|:
Yeast   307 FGNLVTMDWWEGLWLNEGFATWMSWYSCNKFQPEWKVWEQYVTDNLQRALNLDSLRSSHPIEVPV 371

  Fly   414 QMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQKFSYKNAEQDNLWESLTQAAHK 478
            ....||::.||.|||.|||::|||:..:||||:|..|:..||.||.|.||:..:||::|..|:.|
Yeast   372 NNADEINQIFDAISYSKGSSLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTGDLWDALADASGK 436

  Fly   479 YRSLPKSYDIKSIMDSWTLQTGYPVINVTRDYAARTAKLNQERYLLNTQVARAYRGGCWWVPLSY 543
                    |:.|:|:.||.:.|:||::|.......|  |.|.|||
Yeast   437 --------DVCSVMNIWTKRVGFPVLSVKEHKNKIT--LTQHRYL-------------------- 471

  Fly   544 TTQAVQDFNNTA--PKAWMECGKNGESLPKTIQDLPGPDQWVIFNTQLST-------LYKVN--- 596
            :|..|::..:|.  |            :...::|..|.|..::.|.:.:|       .:|:|
Yeast   472 STGDVKEEEDTTIYP------------ILLALKDSTGIDNTLVLNEKSATFELKNEEFFKINGDQ 524

  Fly   597 -------YDAQNWKLLIETLTNGDFERIHVINRAQLIDDALYLAWTGEQDYEIAMRLIEYLQRER 654
                   |..:.|..|     :.....:.|.:|..|:.||..|:.:|.......:.||...:.|.
Yeast   525 SGIFITSYSDERWAKL-----SKQANLLSVEDRVGLVADAKALSASGYTSTTNFLNLISNWKNED 584

  Fly   655 EYLPWKSAFENLKRVGRIVRQTPDFE------FFKRYMKKLILPIYEHLN---GINDTFSAIPQQ 710
            .::.|:....:|.    .::.|..||      ...::...|:|.....|.   |.:|:| ||.:
Yeast   585 SFVVWEQIINSLS----ALKSTWVFEPEDILNALDKFTLDLVLNKLSELGWNIGEDDSF-AIQR- 643

  Fly   711 DQVLLKTMVVNWACQYQVGDCVPQALAY-----YRNWRAEANPDEKNPVPINVRSTVYCTSIKHG 770
                ||..:.:.||  ..|:...|::|.     |.|       ..|..:|...::.|:.|..:.|
Yeast   644 ----LKVTLFSAAC--TSGNEKMQSIAVEMFEEYAN-------GNKQAIPALFKAVVFNTVARLG 695

  Fly   771 SDSDWEFLWTRYKKSNVAAEKRTILTALGCSREVWLLQRYLELTFDPKEAIRKQDSMWAFQAVAF 835
            .::::|.::..|:....:.||...|.|||...:..||:|.|....|  ..:..||.....|.:..
Yeast   696 GENNYEKIFNIYQNPVSSEEKIIALRALGRFEDKELLERTLSYLLD--GTVLNQDFYIPMQGIRV 758

  Fly   836 NEVGFLLAKKYFMDNVDFIYKFYHPLTKDMSRLLSPLSEQVIT--LSDFNEF----KDFVNNSRQ 894
            ::.|......:..::.|.|.|...|        .||:...|:|  |::|..|    |.....||:
Yeast   759 HKKGIERLWAWMQEHWDEIAKRLQP--------GSPVLGGVLTLGLTNFTSFEALEKISAFYSRK 815

  Fly   895 SLKGLEQAIQQTLEIMLTNVQWKERN 920
            ..||.:|.:.|.|:.:.:..||..|:
Yeast   816 VTKGFDQTLAQALDTIRSKAQWVSRD 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_652618.1	M1_APN-Q_like	42..497	CDD:341064	190/464 (41%)
		ERAP1_C	582..910	CDD:463368	80/364 (22%)
AAP1	NP_011913.1	M1_APN-Q_like	13..447	CDD:341064	190/465 (41%)
		ERAP1_C	517..833	CDD:463368	78/349 (22%)