DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and AAP1

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_011913.1	Gene:	AAP1 / 856443	SGDID:	S000001089	Length:	856	Species:	Saccharomyces cerevisiae

Alignment Length:	936	Identity:	294/936 - (31%)
Similarity:	438/936 - (46%)	Gaps:	149/936 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LPTSLRPQKYHLRILTLLENPEDLRFSGSVKILIEALENTKNVTLHSKNLTIDESQITLRQIGG- 97
            ||.::.|..|.   :||..|.....|.||:||.::..:::.| ::....|.||.....:..:..
Yeast     6 LPNNVTPLHYD---ITLEPNFRAFTFEGSLKIDLQINDHSIN-SVQINYLEIDFHSARIEGVNAI 66

  Fly    98 -EGKKENCVSSTAVNPSHDFYILNTCQELLAGNTYELYMPFAADLNRQLEGYYRSSYKDPVANLT 161
             ..|.||...:|.|.|:..|..|        |.:.:|.:.|:..||.|:.|:||:.|.|.|...|
Yeast    67 EVNKNENQQKATLVFPNGTFENL--------GPSAKLEIIFSGILNDQMAGFYRAKYTDKVTGET 123

  Fly   162 KWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAISNMPE-----KETKPHETLADYI 221
            |:::.||.|...||.||||||||:.||.|.|||......|.:|||..     ||.|.:.|
Yeast   124 KYMATTQMEATDARRAFPCFDEPNLKATFAVTLVSESFLTHLSNMDVRNETIKEGKKYTT----- 183

  Fly   222 WCEFQESVPMSTYLVAYSVNDFSHKPST---LPNSALFRTWARPNAIDQCDYAAQFGPKVLQYYE 283
               |..:..|||||||:.|.|..:..|.   :|    .|.::.|.......:||....:.|:::|
Yeast   184 ---FNTTPKMSTYLVAFIVADLRYVESNNFRIP----VRVYSTPGDEKFGQFAANLAARTLRFFE 241

  Fly   284 QFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAHSSLADKQRVASVVAHELAHQW 348
            ..|.|::||||:|.:||.:|||||||||||||||.|.||....:|||...||||.|:.|||||||
Yeast   242 DTFNIEYPLPKMDMVAVHEFSAGAMENWGLVTYRVIDLLLDIENSSLDRIQRVAEVIQHELAHQW 306

  Fly   349 FGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWRSMEQESLSNLLTIFRRDALESSHPISRPI 413
            |||||||.||..|||||||||:::........|||:..||....||......|:|.|||||..|:
Yeast   307 FGNLVTMDWWEGLWLNEGFATWMSWYSCNKFQPEWKVWEQYVTDNLQRALNLDSLRSSHPIEVPV 371

  Fly   414 QMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQKFSYKNAEQDNLWESLTQAAHK 478
            ....||::.||.|||.|||::|||:..:||||:|..|:..||.||.|.||:..:||::|..|:.|
Yeast   372 NNADEINQIFDAISYSKGSSLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTGDLWDALADASGK 436

  Fly   479 YRSLPKSYDIKSIMDSWTLQTGYPVINVTRDYAARTAKLNQERYLLNTQVARAYRGGCWWVPLSY 543
                    |:.|:|:.||.:.|:||::|.......|  |.|.|||
Yeast   437 --------DVCSVMNIWTKRVGFPVLSVKEHKNKIT--LTQHRYL-------------------- 471

  Fly   544 TTQAVQDFNNTA--PKAWMECGKNGESLPKTIQDLPGPDQWVIFNTQLST-------LYKVN--- 596
            :|..|::..:|.  |            :...::|..|.|..::.|.:.:|       .:|:|
Yeast   472 STGDVKEEEDTTIYP------------ILLALKDSTGIDNTLVLNEKSATFELKNEEFFKINGDQ 524

  Fly   597 -------YDAQNWKLLIETLTNGDFERIHVINRAQLIDDALYLAWTGEQDYEIAMRLIEYLQRER 654
                   |..:.|..|     :.....:.|.:|..|:.||..|:.:|.......:.||...:.|.
Yeast   525 SGIFITSYSDERWAKL-----SKQANLLSVEDRVGLVADAKALSASGYTSTTNFLNLISNWKNED 584

  Fly   655 EYLPWKSAFENLKRVGRIVRQTPDFE------FFKRYMKKLILPIYEHLN---GINDTFSAIPQQ 710
            .::.|:....:|.    .::.|..||      ...::...|:|.....|.   |.:|:| ||.:
Yeast   585 SFVVWEQIINSLS----ALKSTWVFEPEDILNALDKFTLDLVLNKLSELGWNIGEDDSF-AIQR- 643

  Fly   711 DQVLLKTMVVNWACQYQVGDCVPQALAY-----YRNWRAEANPDEKNPVPINVRSTVYCTSIKHG 770
                ||..:.:.||  ..|:...|::|.     |.|       ..|..:|...::.|:.|..:.|
Yeast   644 ----LKVTLFSAAC--TSGNEKMQSIAVEMFEEYAN-------GNKQAIPALFKAVVFNTVARLG 695

  Fly   771 SDSDWEFLWTRYKKSNVAAEKRTILTALGCSREVWLLQRYLELTFDPKEAIRKQDSMWAFQAVAF 835
            .::::|.::..|:....:.||...|.|||...:..||:|.|....|  ..:..||.....|.:..
Yeast   696 GENNYEKIFNIYQNPVSSEEKIIALRALGRFEDKELLERTLSYLLD--GTVLNQDFYIPMQGIRV 758

  Fly   836 NEVGFLLAKKYFMDNVDFIYKFYHPLTKDMSRLLSPLSEQVIT--LSDFNEF----KDFVNNSRQ 894
            ::.|......:..::.|.|.|...|        .||:...|:|  |::|..|    |.....||:
Yeast   759 HKKGIERLWAWMQEHWDEIAKRLQP--------GSPVLGGVLTLGLTNFTSFEALEKISAFYSRK 815

  Fly   895 SLKGLEQAIQQTLEIMLTNVQWKERN 920
            ..||.:|.:.|.|:.:.:..||..|:
Yeast   816 VTKGFDQTLAQALDTIRSKAQWVSRD 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	165/406 (41%)
		M1_APN_2	43..502	CDD:189008	192/468 (41%)
		ERAP1_C	583..908	CDD:288671	79/361 (22%)
AAP1	NP_011913.1	PepN	2..844	CDD:223385	294/936 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
TreeFam	0	0.000	Not matched by this tool.
	5	4.910