Protein Alignment SP1029 and LAP2

DIOPT Version :10

• Sequence 1: NP_652618.1
• Gene: SP1029 / 53473
• FlyBaseID: FBgn0263236
• Length: 932
• Species: Drosophila melanogaster
• Sequence 2: NP_014353.1
• Gene: LAP2 / 855682
• SGDID: S000004990
• Length: 671
• Species: Saccharomyces cerevisiae
• Alignment Length: 779
• Identity: 169/779 - (21%)
• Similarity: 289/779 - (37%)
• Gaps: 214/779 - (27%)

  Fly    14 GLATADSSADSIETTYNYYRLPTSL---RPQKYHLRILTLLENPEDL----------------RF 59
            ||.|..|....|.|.:.  .||.|:   ||.:......:.|.|.:|.                ..
Yeast    23 GLLTVISRNIHISTPHK--MLPLSIEQRRPSRSPEYDQSTLSNYKDFAVLHTDLNLSVSFEKSAI 85

  Fly    60 SGSVKILIEALENTKNVTLHSKNLTIDESQITLRQIGGEGKKENCVSSTAVNPSHDFYILN--TC 122
            ||||...::.|...||   .|..|.:|.|.:.::::..:|.|.:........|.....::|  :|
Yeast    86 SGSVTFQLKKLHEGKN---KSDELHLDTSYLDVQEVHIDGSKADFQIEQRKEPLGSRLVINNASC 147

  Fly   123 QELLAGNTYELYMPFAADLNRQLEGYYRSSYKDPVANLTKWIS-----------VTQFEPASARL 176
            .:                 |..|...:|::.|   ....:|::           .:|.|...||.
Yeast   148 ND-----------------NFTLNIQFRTTDK---CTALQWLNSKQTKGGKPYVFSQLEAIHARS 192

  Fly   177 AFPCFDEPDFKAPFVVTLGYHKKYTAISNMPE--KETKPHETLADYIWCEFQESVPMSTYLVAYS 239
            .|||||.|..|:.|..::.        |.:|.  ...:..:|..|.....|::.||:..||:..:
Yeast   193 LFPCFDTPSVKSTFTASIE--------SPLPVVFSGIRIEDTSKDTNIYRFEQKVPIPAYLIGIA 249

  Fly   240 VNDFSHKPSTLPNSALFRTWARPNAIDQCDYA--------AQFGPKVLQYYEQFFGIKFPLPKID 296
            ..|.|..|.. |.|.::   ..|..:..|.:.        .|...|::..||  :|....|..:|
Yeast   250 SGDLSSAPIG-PRSTVY---TEPFRLKDCQWEFENDVEKFIQTAEKIIFEYE--WGTYDILVNVD 308

  Fly   297 QIAVPDFSAGAMENWGLVTYREIALLYSAAHSSLADKQRVASVVAHELAHQWFGNLVTMKWWTDL 361
                 .:..|.||:..: |:....|:   ||    |:..: .|:||||||.|.|||||...|...
Yeast   309 -----SYPYGGMESPNM-TFATPTLI---AH----DRSNI-DVIAHELAHSWSGNLVTNCSWNHF 359

  Fly   362 WLNEGFATYVASLGVENINPE----------WRSMEQESLSNLLTIFRRDALESSHPISRPIQMV 416
            |||||:..|:....:..|:.|          |..: |.|:         |:::.....|..:|.:
Yeast   360 WLNEGWTVYLERRIIGAIHGEPTRHFSALIGWSDL-QNSI---------DSMKDPERFSTLVQNL 414

  Fly   417 SEIS---ESFDQISYQKGSTVLRMMHLFL-GEESFRSGLQAYLQKFSYKNAEQDNLWESLTQAAH 477
            ::.:   ::|..:.|:||..:|..:...| |:..|...::.|.:||:.|:.:.....::|
Yeast   415 NDNTDPDDAFSTVPYEKGFNLLFHLETILGGKAEFDPFIRHYFKKFAKKSLDTFQFLDTL----- 474

  Fly   478 KYRSLPKSYDIKSIMDS-----WTLQTGYPVINVTRDYAARTAKLNQERYLLNTQVARAYRGGCW 537
             |...|:.   |.|:||     |..:.|.|
Yeast   475 -YEFYPEK---KEILDSVDWETWLYKPGMP----------------------------------- 500

  Fly   538 WVPLSYTTQAVQDFNNTAPKAWMECGKNGESLPKTIQDLPGPDQWVIFNTQLSTLYKVNYDAQNW 602
              |..:...|:.|........|:|..::    .||.:|         |.::.:.:...::::...
Yeast   501 --PRPHFITALADNVYQLADKWVEMAQH----LKTTED---------FRSEFNAIDIKDFNSNQL 550

  Fly   603 KLLIETLT-NG---------DFERIHVINRAQLIDDALYLAWTGEQDYEIAMRLIEY-----LQR 652
            .|.:|||| ||         |:.:..|.:||.|  |.........|:.|:..::.::     ||.
Yeast   551 VLFLETLTQNGHSNKKPKDFDWAKFPVASRALL--DIYQDNIVKSQNAEVVFKMFKFQIFAKLQE 613

  Fly   653 EREYL-PWKSAFENLKRVGRIVRQTPDFEFFKRYMKKLILPIYEHLNGINDTF----SAIPQQD 711
            |.::| .|      |..|||:....|.:.......::|.|..::.   ..||:    .|:.:||
Yeast   614 EYKHLADW------LGTVGRMKFVRPGYRLLNSVDRRLALATFDK---FKDTYHPICKALVKQD 668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_652618.1	M1_APN-Q_like	42..497	CDD:341064	115/512 (22%)
		ERAP1_C	582..910	CDD:463368	33/150 (22%)
LAP2	NP_014353.1	leuko_A4_hydro	57..669	CDD:274120	158/743 (21%)