DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and TMA108

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_012129.1	Gene:	TMA108 / 854669	SGDID:	S000001399	Length:	946	Species:	Saccharomyces cerevisiae

Alignment Length:	976	Identity:	210/976 - (21%)
Similarity:	408/976 - (41%)	Gaps:	191/976 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 NYYRLPTSLRPQKYHLRILTLLENPEDLRFSGSVKILIEALENTKNVT----------LHSKNLT 84
            |...|...:.|..|.|| |.:........|.||..|.::...|:..:.          ||||:|.
Yeast     4 NLLSLENPVVPSHYELR-LEIDPKQSSPNFKGSAIIHLKFNPNSTTLASIEDSFTQFKLHSKDLI 67

  Fly    85 IDESQITLRQIGGEGKKENCVSS------TAVNPSHDFYILNTCQELLAGNTYELYMPFAADLNR 143
            :..:..|:    |..|.:..:|.      :..|......:.|.|..:|:..    |:....|:..
Yeast    68 VLSAHATI----GSTKFDLKISQDTGKHLSIFNSESPIQLSNDCPLILSVQ----YVGKIRDIKT 124

  Fly   144 QLE---GYYRSSYKD-PVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAIS 204
            ..:   |.:::::.| ........:..|..:|.||...|||.|||..|:.|.:.:....:|.|:|
Yeast   125 HHDKTFGIFKTNFMDRKTGTANNHVVATHCQPFSASNIFPCIDEPSNKSTFQLNIATDAQYKAVS 189

  Fly   205 NMPEKETKPHETLADYIWCEFQESVPMSTYLVAYSVNDFSHKPS--------TLPNSALFRTWAR 261
            |.|.:..:..::...:: .:|.::..|:|.:..:|:.|.....:        |:|.| ::..|..
Yeast   190 NTPVEMVEALDSSQKHL-VKFAKTPLMTTSVFGFSIGDLEFLKTEIKLEGDRTIPVS-IYAPWDI 252

  Fly   262 PNAIDQCDYAAQFGPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAA 326
            .||....|...::.|.:    |.:|...:||||:|.:.:|..|..||||:|::|.:...||...
Yeast   253 ANAAFTLDTVQKYLPLL----ESYFKCPYPLPKLDFVLLPYLSDMAMENFGMITIQLNHLLIPP- 312

  Fly   327 HSSLAD---KQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVE---NINPEWRS 385
             ::||:   :::...::.|||.|||.||.::...|..||.||.|||::|...:|   :::..|.|
Yeast   313 -NALANETVREQAQQLIVHELVHQWMGNYISFDSWESLWFNESFATWLACHILEQNGDLSHYWTS 376

  Fly   386 MEQESLSNLLTIFRRDALESSHPISRPIQMV--------SEISESFDQISYQKGSTVLRMMHLFL 442
             |...|..:.....|||.:.:   .|.|..:        |:.|:.||..:|.||..:||.:.|..
Yeast   377 -EPYLLQQVEPTMCRDAADVN---GRSIFQIAQRNTGIDSQTSDIFDPEAYTKGIIMLRSLQLAT 437

  Fly   443 GEESFRSGLQAYLQ---KFSYKNAEQDNLWESLTQAAHKYRSLPKSYDIKSIMDSWTLQTGYPVI 504
            ||...:.||::..:   .|..::.:..::|..:.:       ..||.:|.:.:.|||...|.||:
Yeast   438 GESHLQKGLESVFEDTKTFHARSVKPMDIWNHIGK-------FLKSQNITNFVSSWTRTPGLPVV 495

  Fly   505 NV---TRDYAARTAKLNQERYL--LNTQVARAYRGGCWWVPLSYTTQAVQDFNNTAPKAWMECGK 564
            .|   .:|...:| ||.|.|::  |:|:.........:.|||.          ...|...|:. |
Yeast   496 KVEVEEKDGKTQT-KLTQHRFINQLSTEEKDQLEDVPYQVPLF----------GVLPDGKMDT-K 548

  Fly   565 NGESLPKTIQ-DLPGPDQWVIFNTQLSTLYKVNYDAQ------NWKLLIETLTNGDFERIHVINR 622
            |.....:|:: |.|    .::.|......|:|:|:::      |.|:..|||:..|..:| .::.
Yeast   549 NVLLTDRTLKFDYP----ILVINHLAQGYYRVSYESEECYALINDKITEETLSEIDLRKI-FLDL 608

  Fly   623 AQLIDDALYLAWTGEQDYEIAM------RLIEYLQ------REREYLPWKSAFENLKRVGRIVRQ 675
            :|.|         |::.::.::      :::.::.      ..:.:.|.....|.|:.:.|....
Yeast   609 SQFI---------GDEGFQNSIHLHGLFKILNHIASPSTKIASKYWDPLSKGLEVLQTIDRASLT 664

  Fly   676 TPDFEFFKRYMKKLILPIYEHLNGINDTF--SAIPQQDQVLLKTMVVNWACQYQVGDCVPQALAY 738
            :...:.|.:  ||:::|::..::..:..|  |..|.:.:|:.:.:.:|    .....|......|
Yeast   665 SSKLQSFLK--KKIVIPLFNKIDWPHGEFDKSTNPHELKVMSQVLFLN----KNSAKCAELCQIY 723

  Fly   739 YRNWRAEANPDEKNPVPINVRSTV------YCTSIKHGSDSDWEFLWTRYKKSNVAAEKRTILTA 797
            :::    .....::.||:.:.:::      :|.:||     .|:.::...|:|:.......::.
Yeast   724 FKH----LLQGPRSSVPLELVNSILVVVSQHCANIK-----QWKKIFDLVKRSSCTGITNHVIN- 778

  Fly   798 LGCSREVWLLQRYLELTFDPKEAIRKQDSMWAFQAVAFNEVGFLLAKKYFMDNVDFIYKFYHPLT 862
                            .:|...:    ::....|..|...:||.|       :.|.:.|..:.:|
Yeast   779 ----------------MYDQNSS----ETAMLIQNGAIESLGFCL-------DSDIVKKTLNFIT 816

  Fly   863 KDMSRLLSPLSEQV-ITLSDFN-EFKDFVNNSRQSLKGLEQAIQQTLEIMLTNVQWKERNYHQMS 925
            .::.      ||.: :.|..|| .||..:|.:.   |..:|.:::|:      .:|...|:.|.:
Yeast   817 SNIE------SEGMELALFGFNYNFKKRLNKNE---KPQDQVVRETI------WEWYMGNFDQWA 866

  Fly   926 R 926
            |
Yeast   867 R 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	109/439 (25%)
		M1_APN_2	43..502	CDD:189008	125/503 (25%)
		ERAP1_C	583..908	CDD:288671	57/352 (16%)
TMA108	NP_012129.1	PepN	7..941	CDD:223385	209/973 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910