DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and APE2

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_012765.3	Gene:	APE2 / 853699	SGDID:	S000001640	Length:	952	Species:	Saccharomyces cerevisiae

Alignment Length:	947	Identity:	288/947 - (30%)
Similarity:	457/947 - (48%)	Gaps:	114/947 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ATADSSADSIETTYNYYRLPTSLRPQKYHLRILTLLENPEDLRFSGSVKILIE----ALE----N 72
            |....::..:..|.|...||.::.|..|.   ||:..:.:..:|.|||||.::    |::    |
Yeast    84 AKCQKTSQLLNKTPNREILPDNVVPLHYD---LTVEPDFKTFKFEGSVKIELKINNPAIDTVTLN 145

  Fly    73 TKNVTLHSKNLTIDESQITLRQIGGEGKKENCVSSTAVNPSHDFYILNTCQELLAGNTYELYMPF 137
            |.:..:||..:    ..:|..:|..|  :|..|::        |...........||.: |.:.|
Yeast   146 TVDTDIHSAKI----GDVTSSEIISE--EEQQVTT--------FAFPKGTMSSFKGNAF-LDIKF 195

  Fly   138 AADLNRQLEGYYRSSYKDPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTA 202
            ...||..:.|:||:.|:|.:...||:::.||.||..||.||||||||:.||.|.:||......|.
Yeast   196 TGILNDNMAGFYRAKYEDKLTGETKYMATTQMEPTDARRAFPCFDEPNLKASFAITLVSDPSLTH 260

  Fly   203 ISNMPEKETKPHE----TLADYIWCEFQESVPMSTYLVAYSVNDFSH---KPSTLPNSALFRTWA 260
            :|||..|.....:    ||       |..:..|||||||:.|.:..:   |...:|    .|.:|
Yeast   261 LSNMDVKNEYVKDGKKVTL-------FNTTPKMSTYLVAFIVAELKYVESKNFRIP----VRVYA 314

  Fly   261 RPNAIDQCDYAAQFGPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSA 325
            .|.......:||....|.|.::|:.|||::||||:|.:||.:|||||||||||||||.:.||...
Yeast   315 TPGNEKHGQFAADLTAKTLAFFEKTFGIQYPLPKMDNVAVHEFSAGAMENWGLVTYRVVDLLLDK 379

  Fly   326 AHSSLADKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWRSMEQ-- 388
            .:|:|...||||.||.||||||||||||||.||..|||||||||:::........|||:..||
Yeast   380 DNSTLDRIQRVAEVVQHELAHQWFGNLVTMDWWEGLWLNEGFATWMSWYSCNEFQPEWKVWEQYV 444

  Fly   389 -ESLSNLLTIFRRDALESSHPISRPIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQ 452
             ::|.:.|::   |:|.|||||..|::...||::.||.|||.||:::|||:..:||||:|..|:.
Yeast   445 TDTLQHALSL---DSLRSSHPIEVPVKKADEINQIFDAISYSKGASLLRMISKWLGEETFIKGVS 506

  Fly   453 AYLQKFSYKNAEQDNLWESLTQAAHKYRSLPKSYDIKSIMDSWTLQTGYPVINVTRDYAARTAKL 517
            .||.||.|.||:.::||::|..|:.|        |::|:|:.||.:.|:|||:|:.|...:.. .
Yeast   507 QYLNKFKYGNAKTEDLWDALADASGK--------DVRSVMNIWTKKVGFPVISVSEDGNGKIT-F 562

  Fly   518 NQERYLLNTQVARAYRGGCWWVPLSYTTQAVQDFNNTAPKAWMECGKNG-------ESLPKTIQD 575
            .|.|||....|........:.|.|:..|                  |||       ....||| :
Yeast   563 RQNRYLSTADVKPDEDKTIYPVFLALKT------------------KNGVDSSVVLSERSKTI-E 608

  Fly   576 LPGPDQWVIFNTQLSTLYKVNYDAQNWKLLIETLTNGDFERIHVINRAQLIDDALYLAWTGEQDY 640
            |..|..:.: |::.|.:|..:|..:.|..|     ....:.:.|.:|..|:.|...|:.:|....
Yeast   609 LEDPTFFKV-NSEQSGIYITSYTDERWAKL-----GQQADLLSVEDRVGLVADVKTLSASGYTST 667

  Fly   641 EIAMRLIEYLQREREYLPWKSAFENLKRVGRI----VRQTPDFEFFKRYMKKLILPIYEHLN--- 698
            ...:.|:.....|:.::.|.....::..:...    .::|.|  ....:.|:||..:..||.
Yeast   668 TNFLNLVSKWNNEKSFVVWDQIINSISSMKSTWLFEPKETQD--ALDNFTKQLISGMTHHLGWEF 730

  Fly   699 GINDTFSAIPQQDQVLLKTMVVNWACQYQVGDCVPQALAYYRNWRAEANPDEKNPVPINVRSTVY 763
            ..:|:||.  |:    ||..:...||..:..|....||..:.::.:    ..|..:|..::..|:
Yeast   731 KSSDSFST--QR----LKVTMFGAACAARDADVEKAALKMFTDYCS----GNKEAIPALIKPIVF 785

  Fly   764 CTSIKHGSDSDWEFLWTRYKKSNVAAEKRTILTALGCSREVWLLQRYLELTFDPKEAIRKQDSMW 828
            .|..:.|...::|.::..|.......||...|.:||..:|..||:|.|...||  ..:..||...
Yeast   786 NTVARVGGAENYEKVYKIYLDPISNDEKLAALRSLGRFKEPKLLERTLGYLFD--GTVLNQDIYI 848

  Fly   829 AFQAVAFNEVGFLLAKKYFMDNVDFIYKFYHPLTKDMSRLLSPLSEQVITLSDFNEFKDFVNNSR 893
            ..|.:..::.|......:...|.|.:.|...|....:..:::..:....::...:|.|.|.  :.
Yeast   849 PMQGMRAHQEGVEALWNWVKKNWDELVKRLPPGLSMLGSVVTLGTSGFTSMQKIDEIKKFF--AT 911

  Fly   894 QSLKGLEQAIQQTLEIMLTNVQWKERNYHQMSRSIQQ 930
            :|.||.:|::.|:|:.:.:..||..|:...:::.:::
Yeast   912 KSTKGFDQSLAQSLDTITSKAQWVNRDRDVVNKYLKE 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	163/415 (39%)
		M1_APN_2	43..502	CDD:189008	189/476 (40%)
		ERAP1_C	583..908	CDD:288671	68/331 (21%)
APE2	NP_012765.3	PepN	90..941	CDD:223385	287/932 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
TreeFam	0	0.000	Not matched by this tool.
	5	4.910