Protein Alignment SP1029 and AOPEP

DIOPT Version :9

• Sequence 1: NP_001263065.1
• Gene: SP1029 / 53473
• FlyBaseID: FBgn0263236
• Length: 932
• Species: Drosophila melanogaster
• Sequence 2: NP_001372995.1
• Gene: AOPEP / 84909
• HGNCID: 1361
• Length: 859
• Species: Homo sapiens
• Alignment Length: 655
• Identity: 131/655 - (20%)
• Similarity: 236/655 - (36%)
• Gaps: 174/655 - (26%)

  Fly   122 CQELLAG-NTYELYM-----PFAADLNRQLEGYYRSSYKDPVANLTKWIS--------VTQFEPA 172
            |.|||.. :|:.|.:     ..|.|....:..:|::.   |......|.|        .|...|.
Human   215 CGELLFDTDTWSLQIRKTGAQTATDFPHAIRIWYKTK---PEGRSVTWTSDQSGRPCVYTVGSPI 276

  Fly   173 SARLAFPCFDEPDFKAPFVVTLGYHKKYTAISNMPEKETKPHETLADYIWCE-----FQESVPM- 231
            :.|..|||.:.|...:.:..|:.....:..:.: .|...||.:     :|.|     :..::||
Human   277 NNRALFPCQEPPVAMSTWQATVRAAASFVVLMS-GENSAKPTQ-----LWEECSSWYYYVTMPMP 335

  Fly   232 -STYLVA-----------YSVNDFSHKPSTLPNSALFRTWARPNAIDQCDYAAQFG--------- 275
             ||:.:|           :|.||.:.:....|:.|.||   ........:|..:|.
Human   336 ASTFTIAVGCWTEMKMETWSSNDLATERPFSPSEANFR---HVGVCSHMEYPCRFQNASATTQEI 397

  Fly   276 -----------------------PKVLQYYEQFFGIKFPLPKIDQIAVP-DFSAGAMENWGLVTY 316
                                   |..|.......| ..|..::|.:.|| :|.:..|.: ..:.:
Human   398 IPHRVFAPVCLTGACQETLLRLIPPCLSAAHSVLG-AHPFSRLDVLIVPANFPSLGMAS-PHIMF 460

  Fly   317 REIALLYSAAHSSLADKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASL---GVEN 378
            ...::|....|       ...:.:.||:||.|||..:..:.||:.||:|||||::..:   ..:.
Human   461 LSQSILTGGNH-------LCGTRLCHEIAHAWFGLAIGARDWTEEWLSEGFATHLEDVFWATAQQ 518

  Fly   379 INPEWRSMEQESLSNLLTIFRR--DALESS---HPISRPIQ-MVSEISES--------------F 423
            :.| :.:.||:.|...|. :||  |.::.|   ..:.||.: .....|:|              |
Human   519 LAP-YEAREQQELRACLR-WRRLQDEMQCSPEEMQVLRPSKDKTGHTSDSGASVIKHGLNPEKIF 581

  Fly   424 DQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQKFSYKNAEQDNLWESLTQAAHKYRSLPKSYDI 488
            .|:.|.||..:||.:...||:|::.|.|:.::..|..:.....:..:.|.:...:.:.|..|  :
Human   582 MQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLILSQDFLQMLLENIPEEKRLELS--V 644

  Fly   489 KSIMDSWTLQTGYPVINVTRDYAARTAKLNQERYL-LNTQVARAYRGGCW-WVPLSYTTQAVQDF 551
            ::|...|...:|.|            ..|.:||.. ....:||..|.... |:.:
Human   645 ENIYQDWLESSGIP------------KPLQRERRAGAECGLARQVRAEVTKWIGV---------- 687

  Fly   552 NNTAPKAWMECGKNGESLPKTIQDLPGPDQWVIFNTQLSTLYKVNYDAQNWKLLIETLTNGDFER 616
             |..|:......|. |...|.:     |||.|:....|              |..:||:.   ..
Human   688 -NRRPRKRKRREKE-EVFEKLL-----PDQLVLLLEHL--------------LEQKTLSP---RT 728

  Fly   617 IHVINRAQLIDDALYLAWTGEQDYEIAMRLIEYLQREREYLPWKSAFENLKRVGRIVRQTPDFEF 681
            :..:.|...:.|         ||.|:..|..|.:.:.:    :..|:::::|..:..::.|..:.
Human   729 LQSLQRTYHLQD---------QDAEVRHRWCELIVKHK----FTKAYKSVERFLQEDQERPQQDS 780

  Fly   682 FKRYM 686
            |.|.:
Human   781 FIRLL 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	82/396 (21%)
		M1_APN_2	43..502	CDD:189008	98/467 (21%)
		ERAP1_C	583..908	CDD:288671	17/104 (16%)
AOPEP	NP_001372995.1	GluZincin	<244..652	CDD:417498	88/432 (20%)
		Nucleolar localization signal. /evidence=ECO:0000250|UniProtKB:Q8BXQ6	689..699		1/9 (11%)
		Leuk-A4-hydro_C	721..>771	CDD:401171	11/65 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155419
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740