Protein Alignment SP1029 and Anpep

DIOPT Version :10

• Sequence 1: NP_652618.1
• Gene: SP1029 / 53473
• FlyBaseID: FBgn0263236
• Length: 932
• Species: Drosophila melanogaster
• Sequence 2: NP_112274.1
• Gene: Anpep / 81641
• RGDID: 2991
• Length: 965
• Species: Rattus norvegicus
• Alignment Length: 937
• Identity: 330/937 - (35%)
• Similarity: 501/937 - (53%)
• Gaps: 71/937 - (7%)

  Fly    16 ATADSSADSIETT--YNYYRLPTSLRPQKYHLRILT-LLENPEDLR-FSGSVKILIEALENTKNV 76
            ||..::..:|:.:  :|.||||.:|.|..|.:.:.. |..|.:.|. |.||..:.....|.|..:
  Rat    56 ATTSTTNPAIDESKPWNQYRLPKTLIPDSYQVTLRPYLTPNEQGLYIFKGSSTVRFTCNETTNVI 120

  Fly    77 TLHSKNLTIDES---QITLRQIGGEGKKENCVSSTAVNPSHDFYILNTCQELLAGNTYELYMPFA 138
            .:|||.|.....   ::.||.:|......  :.:|.:....::.:::....|:.|:.||:...|.
  Rat   121 IIHSKKLNYTNKGNHRVALRALGDTPAPN--IDTTELVERTEYLVVHLQGSLVKGHQYEMDSEFQ 183

  Fly   139 ADLNRQLEGYYRSSYKDPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAI 203
            .:|...|.|:|||.|.:  ....|.::.||.:.|.||.:|||||||..||.|.:||.:....||:
  Rat   184 GELADDLAGFYRSEYME--GGNKKVVATTQMQAADARKSFPCFDEPAMKASFNITLIHPNNLTAL 246

  Fly   204 SNMPEKETKPHETL-ADYIW--CEFQESVPMSTYLVAYSVNDFSHKPSTLPNSALFRTWARPNAI 265
            |||..|:::   || .|..|  .||..:..|||||:||.|::|.:..:..||....|.||||:||
  Rat   247 SNMLPKDSR---TLQEDPSWNVTEFHPTPKMSTYLLAYIVSEFKYVEAVSPNRVQIRIWARPSAI 308

  Fly   266 DQ--CDYAAQFGPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAHS 328
            |:  .|||.|....:|.::.|.:...:||.|.||||:|||:||||||||||||||.||::....|
  Rat   309 DEGHGDYALQVTGPILNFFAQHYNTAYPLEKSDQIALPDFNAGAMENWGLVTYRESALVFDPQSS 373

  Fly   329 SLADKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWRSMEQESLSN 393
            |:::|:||.:|:||||||||||||||:.||.|||||||||:||..||.:...|.|...:...|::
  Rat   374 SISNKERVVTVIAHELAHQWFGNLVTVDWWNDLWLNEGFASYVEFLGADYAEPTWNLKDLIVLND 438

  Fly   394 LLTIFRRDALESSHPISRPIQMV---SEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYL 455
            :..:...|||.||||:|.|...|   ::|||.||.|:|.||::||||:..||.|:.|:.||.:||
  Rat   439 VYRVMAVDALASSHPLSSPANEVNTPAQISELFDSITYSKGASVLRMLSSFLTEDLFKKGLSSYL 503

  Fly   456 QKFSYKNAEQDNLWESLTQAAHKYRSLPKSYDIKSIMDSWTLQTGYPVINVTRDYAARTAKLNQE 520
            ..|.|.|....:|||.|.||.....::.....:.:|||.|.||.|:|||.|.    ..|.::.||
  Rat   504 HTFQYSNTIYLDLWEHLQQAVDSQTAIKLPASVSTIMDRWILQMGFPVITVN----TSTGEIYQE 564

  Fly   521 RYLLNTQVARAYRGG----CWWVPLSYTTQAVQDFNNTAPKAWMECGKNGESLPKTIQDLPGPDQ 581
            .:||: ..::..|..    .|.||:.|.....:|      ..|:|..||..:..:|     ..::
  Rat   565 HFLLD-PTSKPTRPSDFNYLWIVPIPYLKNGKED------HYWLETEKNQSAEFQT-----SSNE 617

  Fly   582 WVIFNTQLSTLYKVNYDAQNWKLLIETLTNGDFERIHVINRAQLIDDALYLAWTGEQDYEIAMRL 646
            |::.|..::..|:||||..||: .|:.....|...|.||||||:|.|:..||..|:....:.:..
  Rat   618 WLLLNINVTGYYQVNYDENNWR-KIQNQLQTDLSVIPVINRAQIIHDSFNLASAGKLSITLPLSN 681

  Fly   647 IEYLQREREYLPWKSAFENLKRVGRIVRQTPDFEFFKRYMKKLILPIYEHL-----NGINDTFSA 706
            ..:|..|.||:||::|..:|.....:..::..:...|||:||.:.|::.:.     |.::...:.
  Rat   682 TLFLASETEYMPWEAALSSLNYFKLMFDRSEVYGPMKRYLKKQVTPLFAYFKIKTNNWLDRPPTL 746

  Fly   707 IPQQDQVLLKTMVVNWACQYQVGDCVPQALAYYRNWRAEANPDEKNPVPINVRSTVYCTSIKHGS 771
            :.|.:::    ..::.||...:.:|....:..|..|   .|..:.||:..|:||||||.:|..|.
  Rat   747 MEQYNEI----NAISTACSSGLEECRDLVVGLYSQW---MNNSDNNPIHPNLRSTVYCNAIAFGG 804

  Fly   772 DSDWEFLWTRYKKSNVAAEKRTILTALGCSREVWLLQRYLELTFDPKEAIRKQDSMWAFQAVAFN 836
            :.:|.|.|.:::|:.:..|...:.:||.||.|||:|.|||..|.:| :.|||||:.....::|.|
  Rat   805 EEEWNFAWEQFRKATLVNEADKLRSALACSNEVWILNRYLSYTLNP-DYIRKQDATSTIVSIANN 868

  Fly   837 EVGFLLA--------KKYFMDNVDFIYKFYHPLTKDMSRLLSPLSEQVITLSDFNEFKDFVNNSR 893
            .||..|.        ||.|.|.....:.|.: |.:.::|..|...|    |....:||:  :||.
  Rat   869 VVGQTLVWDFVRSNWKKLFEDYGGGSFSFAN-LIQGVTRRFSSEFE----LQQLEQFKE--DNSA 926

  Fly   894 QSLKGLEQAIQQTLEIMLTNVQWKERN 920
            .......:|::|.||....|::|.:.|
  Rat   927 TGFGSGTRALEQALEKTKANIKWVKEN 953

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_652618.1	M1_APN-Q_like	42..497	CDD:341064	192/467 (41%)
		ERAP1_C	582..910	CDD:463368	102/340 (30%)
Anpep	NP_112274.1	Cytosolic Ser/Thr-rich junction	33..68		3/11 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	44..68		3/11 (27%)
		Metalloprotease	69..965		327/924 (35%)
		M1_APN-Q_like	84..545	CDD:341064	192/467 (41%)
		ERAP1_C	618..945	CDD:463368	102/342 (30%)