Protein Alignment SP1029 and Erap1

DIOPT Version :10

• Sequence 1: NP_652618.1
• Gene: SP1029 / 53473
• FlyBaseID: FBgn0263236
• Length: 932
• Species: Drosophila melanogaster
• Sequence 2: NP_109636.1
• Gene: Erap1 / 80898
• MGIID: 1933403
• Length: 930
• Species: Mus musculus
• Alignment Length: 944
• Identity: 305/944 - (32%)
• Similarity: 490/944 - (51%)
• Gaps: 83/944 - (8%)

  Fly    20 SSADSIETTYNYYRLPTSLRPQKYHLRILTLLENPEDLRFSGSVKILIEALENTKNVTLHSKNLT 84
            |:.||.  .:|..|||..:.|..|.|.|..   |...|.|.|..::.|.|...|..:.:||.:|.
Mouse    31 SNGDSF--PWNNMRLPEYMTPIHYDLMIHA---NLSTLTFWGKTEVEIIASRPTSTIIMHSHHLQ 90

  Fly    85 IDESQITLRQIGGEGKKENCVSSTAVNPSHDFYILNTCQELLAGNTYELYMPFAADLNRQLEGYY 149
            |  |:.|||:..||...|..: .....|:|:...|...|.||||:.|.:.:.:||:|:....|:|
Mouse    91 I--SKATLRRGAGEMLSEEPL-KVLEYPAHEQVALLAAQPLLAGSLYTVIIDYAANLSESFHGFY 152

  Fly   150 RSSYKDPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAISNMP-EKETKP 213
            :|:|:.....: :.::.|||||.:||:||||||||..||.|.:.:....::.|||||| .|....
Mouse   153 KSTYRTQEGEM-RILAATQFEPTAARMAFPCFDEPALKASFSIKIKRDPRHLAISNMPLVKSVNV 216

  Fly   214 HETLADYIWCEFQESVPMSTYLVAYSVNDFSHKPSTLPNSALFRTWARPNAIDQCDYAAQFGPKV 278
            .|.|   |...|..:|.|||||||:.::||........:......:|.|:.|:|.|||......:
Mouse   217 AEGL---IEDHFDITVKMSTYLVAFIISDFKSVSKMTKSGVKVSVYAVPDKINQADYALDAAVTL 278

  Fly   279 LQYYEQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAHSSLADKQRVASVVAHE 343
            |::||.:|.|.:||||.|..|:|||.:||||||||.||||.:|||....||.:.|..:..:|:||
Mouse   279 LEFYEDYFNIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESSLLYDKEKSSASSKLGITMIVSHE 343

  Fly   344 LAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWRSMEQESLSNLLTIFRRDALESSHP 408
            ||||||||||||:||.|||||||||.::..:.|...:||.: :|.............|||.||||
Mouse   344 LAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVTVTHPELK-VEDYFFGKCFNAMEVDALNSSHP 407

  Fly   409 ISRPIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQKFSYKNAEQDNLWESL- 472
            :|.|::..::|.|.||.:||:||:.:|.|:..:|..::|:.|:..||||:||||.:.::||.|:
Mouse   408 VSTPVENPAQIREMFDDVSYEKGACILNMLRDYLSADTFKRGIVQYLQKYSYKNTKNEDLWNSMM 472

  Fly   473 -------TQAAHKY--RSLPKS---------YDIKSIMDSWTLQTGYPVINVTRDYAARTAKLNQ 519
                   ||....:  ||...|         .|:|::|::||||.|:|:|.:|  .:.|...:.|
Mouse   473 HICPTDGTQTMDGFCSRSQHSSSTSHWRQEVVDVKTMMNTWTLQKGFPLITIT--VSGRNVHMKQ 535

  Fly   520 ERYLLNTQVARAYRGGCWWVPLSYTT---QAVQDFNNTAPKAWMECGKNGESLPKTIQD---LPG 578
            |.|:..:: .....|..|.|||::.|   .:||.|                 |.||..|   ||.
Mouse   536 EHYMKGSE-RFPETGYLWHVPLTFITSKSDSVQRF-----------------LLKTKTDVLILPE 582

  Fly   579 PDQWVIFNTQLSTLYKVNYDAQNWKLLIETLTNGDFERIHVI----NRAQLIDDALYLAWTGEQD 639
            ..||:.||..::..|.|:|....|..|     :|..:..|..    :||.||::|..|....:..
Mouse   583 AVQWIKFNVGMNGYYIVHYADDGWASL-----SGLLKEAHTTISSNDRASLINNAFQLVSIEKLS 642

  Fly   640 YEIAMRLIEYLQREREYLPWKSAFENLKRVGRIVRQTPDFEF---FKRYMKKLILPIYEHLNGIN 701
            .|.|:.|..||:.|.|.:|...|...|..:.:::.:....|.   ||.::.||:..:.:     .
Mouse   643 IEKALDLTLYLKNETEIMPIFQALNELIPMYKLMEKRDMIEVETQFKDFLLKLLKDLID-----K 702

  Fly   702 DTFSAIPQQDQVLLKTMVVNWACQYQVGDCVPQALAYYRNWRAEANPDEKNPVPINVRSTVYCTS 766
            .|::......:.:|::.::..||......||.:|..|:|.|::.   :....:||:|...|:...
Mouse   703 QTWTDEGSVSERMLRSQLLLLACVRNYQPCVQRAERYFREWKSS---NGNMSIPIDVTLAVFAVG 764

  Fly   767 IKHGSDSDWEFLWTRYKKSNVAAEKRTILTALGCSREVWLLQRYLELTFDPKEAIRKQDSMWAFQ 831
            .:  :...|:||:::|:.|..:.||..|..:|..|::...||..|:.:| ..|.|:.|:......
Mouse   765 AQ--NTEGWDFLYSKYQSSLSSTEKSQIEFSLCTSKDPEKLQWLLDQSF-KGEIIKTQEFPHILT 826

  Fly   832 AVAFNEVGFLLAKKYFMDNVDFIYKFYHPLTKDMSRLLSPLSEQVITLSDFNEFKDFVNNSRQSL 896
            .:..|.||:.||.|:..:|.:.:.:.:...:..::.::...::|..|.:...|.|.|.::.:::.
Mouse   827 LIGRNPVGYPLAWKFLRENWNKLVQKFELGSSSIAHMVMGTTDQFSTRARLEEVKGFFSSLKENG 891

  Fly   897 KGLEQAIQQTLEIMLTNVQWKERNYHQMSRSIQQ 930
            ..| :.:|||:|.:..|::|.::|:.::...:|:
Mouse   892 SQL-RCVQQTIETIEENIRWMDKNFDKIRLWLQK 924

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_652618.1	M1_APN-Q_like	42..497	CDD:341064	187/474 (39%)
		ERAP1_C	582..910	CDD:463368	79/334 (24%)
Erap1	NP_109636.1	M1_APN-Q_like	50..515	CDD:341064	187/475 (39%)
		ERAP1_C	586..905	CDD:463368	79/335 (24%)