DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and Erap1

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	XP_006231762.1	Gene:	Erap1 / 80897	RGDID:	708542	Length:	954	Species:	Rattus norvegicus

Alignment Length:	969	Identity:	312/969 - (32%)
Similarity:	495/969 - (51%)	Gaps:	117/969 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 YNYYRLPTSLRPQKYHLRILTLLENPEDLRFSGSVKILIEALENTKNVTLHSKNLTIDESQITLR 93
            :|..|||..:.|..|.|.|..   |...|.|.|..::.|...:.|..:.:||..|.|  |:.|||
  Rat    38 WNNMRLPEYITPIHYDLMIHA---NLSTLTFWGKTEVEITVSQPTSTIIMHSHQLQI--SKATLR 97

  Fly    94 QIGGEGKKENCVSSTAVNPSHDFYILNTCQELLAGNTYELYMPFAADLNRQLEGYYRSSYKDPVA 158
            :...|...|..:.....: :|:...|.|.|.||||:.|.:.:.:||:|:....|:|:|:|:....
  Rat    98 RGAEEMLPEEPLKLMEYS-AHEQVALLTAQPLLAGSVYTVIITYAANLSENFHGFYKSTYRTQEG 161

  Fly   159 NLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAISNMP--EKETKPHETLADYI 221
            . .:.::.|||||.:||:||||||||..||.|.:.:....::.||||||  :..|.....:.|:
  Rat   162 E-RRILAATQFEPTAARMAFPCFDEPALKASFSIKIKRDPRHLAISNMPLVKSVTVAEGLIEDH- 224

  Fly   222 WCEFQESVPMSTYLVAYSVNDFSHKPSTLPNSALFRTWARPNAIDQCDYAAQFGPKVLQYYEQFF 286
               |..:|.|||||||:.::||........:......:|.|:.|:|.|||......:|::||.:|
  Rat   225 ---FDITVKMSTYLVAFIISDFKSVSKMTKSGVKVSVYAVPDKINQADYALDAAVTLLEFYEDYF 286

  Fly   287 GIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAHSSLADKQRVASVVAHELAHQWFGN 351
            .|.:||||.|..|:|||.:||||||||.||||.||||....||.:.|..:...|:||||||||||
  Rat   287 SIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLYDKEKSSASSKLGITMTVSHELAHQWFGN 351

  Fly   352 LVTMKWWTDLWLNEGFATYVASLGVENINPEWRSM---------EQESLS--------------- 392
            ||||:||.|||||||||.::..:.|...:||.:.|         |.|.||
  Rat   352 LVTMEWWNDLWLNEGFAKFMEFVSVTVTHPELKVMQILTANHQNEPEDLSGRAMERTEEEYFFGK 416

  Fly   393 --NLLTIFRRDALESSHPISRPIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYL 455
              |.:.:   |||.||||:|.|::..::|.|.||::||:||:.:|.|:..:|..::|:.|:..||
  Rat   417 CFNAMEV---DALNSSHPVSTPVENPAQIREMFDEVSYEKGACILNMLRDYLSADTFKRGIVQYL 478

  Fly   456 QKFSYKNAEQDNLWESL--------TQ-----AAHKYRSLPKSY------DIKSIMDSWTLQTGY 501
            ||:||||.:.::||.|:        ||     .:....|...|:      ||||:|::||||.|:
  Rat   479 QKYSYKNTKNEDLWNSMMHICPTDGTQTMDGFCSRNQHSSSTSHWRQEVIDIKSMMNTWTLQKGF 543

  Fly   502 PVINVTRDYAARTAKLNQERYLLNTQVARAYRGGCWWVPLSYTT---QAVQDFNNTAPKAWMECG 563
            |:|.:|  ...|...|.||.|:..:: .....|..|.|||::.|   .:||.|
  Rat   544 PLITIT--VRGRNVHLKQEHYMKGSE-CFPETGSLWHVPLTFITSKSDSVQRF------------ 593

  Fly   564 KNGESLPKTIQD---LPGPDQWVIFNTQLSTLYKVNYDAQNWKLLIETLTNGDFERIHVI----N 621
                 |.||..|   ||...:|:.||..::..|.|:|....|..|     ||..:..|..    :
  Rat   594 -----LLKTKTDVIILPEAVEWIKFNVGMNGYYIVHYGDDGWASL-----NGLLKEAHTTISSND 648

  Fly   622 RAQLIDDALYLAWTGEQDYEIAMRLIEYLQREREYLPWKSAFENLKRVGRIVRQTPDFEF---FK 683
            ||.||::|..|...|:...|.|:.||.||:.|.|.:|.......|..:.:::.:....|.   ||
  Rat   649 RASLINNAFQLVSIGKLSIEKALDLILYLKNETEIMPIFQGLNELIPMYKLMEKRDMVEVETQFK 713

  Fly   684 RYMKKLILPIYEHLNGIN-DTFSAIPQQDQVLLKTMVVNWACQYQVGDCVPQALAYYRNWRAEAN 747
            .::.:|:..:      || .|::......:.:|::.::..||.::...||.:|..|:|.|:|.
  Rat   714 DFLLRLLKDL------INKQTWTDEGSVSERMLRSQLLLLACVHRYQLCVQRAERYFREWKAS-- 770

  Fly   748 PDEKNPVPINVRSTVYCTSIKHGSDSDWEFLWTRYKKSNVAAEKRTILTALGCSREVWLLQRYLE 812
             :....:||:|...|:....:  :...|:||:::|:.|..:.||..|..:|..|::...||..|:
  Rat   771 -NGNMSLPIDVTLAVFAVGAQ--NTEGWDFLYSKYQSSLSSTEKSQIEFSLCISQDPEKLQWLLD 832

  Fly   813 LTFDPKEAIRKQDSMWAFQAVAFNEVGFLLAKKYFMDNVDFIYKFYHPLTKDMSRLLSPLSEQVI 877
            .:| ..|.|:.|:.......:..|.||:.||.|:..:|.:.|.:.:...:..::.::...:.|..
  Rat   833 QSF-KGEIIKTQEFPHILTLIGRNPVGYPLAWKFLKENWNKIVQKFELGSSSIAHMVMGTTNQFS 896

  Fly   878 TLSDFNEFKDFVNNSRQSLKGLEQAIQQTLEIMLTNVQWKERNYHQ----MSRSIQQLL 932
            |.:...|.|.|.::.:::...| :.:|||:|.:..|::|.::|:.:    :.:..|:||
  Rat   897 TRARLEEVKGFFSSLKKNGSQL-RCVQQTIETIEENIRWMDKNFDKIRLWLQKERQELL 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	166/425 (39%)
		M1_APN_2	43..502	CDD:189008	194/505 (38%)
		ERAP1_C	583..908	CDD:288671	82/332 (25%)
Erap1	XP_006231762.1	Peptidase_M1	42..454	CDD:279741	166/425 (39%)
		M1_APN_2	50..544	CDD:189008	194/507 (38%)
		ERAP1_C	611..927	CDD:288671	82/333 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349257
Domainoid	1	1.000	119	1.000	Domainoid score	I5647
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.750