Protein Alignment SP1029 and Erap1

DIOPT Version :10

• Sequence 1: NP_652618.1
• Gene: SP1029 / 53473
• FlyBaseID: FBgn0263236
• Length: 932
• Species: Drosophila melanogaster
• Sequence 2: XP_006231762.1
• Gene: Erap1 / 80897
• RGDID: 708542
• Length: 954
• Species: Rattus norvegicus
• Alignment Length: 969
• Identity: 312/969 - (32%)
• Similarity: 495/969 - (51%)
• Gaps: 117/969 - (12%)

  Fly    29 YNYYRLPTSLRPQKYHLRILTLLENPEDLRFSGSVKILIEALENTKNVTLHSKNLTIDESQITLR 93
            :|..|||..:.|..|.|.|..   |...|.|.|..::.|...:.|..:.:||..|.|  |:.|||
  Rat    38 WNNMRLPEYITPIHYDLMIHA---NLSTLTFWGKTEVEITVSQPTSTIIMHSHQLQI--SKATLR 97

  Fly    94 QIGGEGKKENCVSSTAVNPSHDFYILNTCQELLAGNTYELYMPFAADLNRQLEGYYRSSYKDPVA 158
            :...|...|..:.....: :|:...|.|.|.||||:.|.:.:.:||:|:....|:|:|:|:....
  Rat    98 RGAEEMLPEEPLKLMEYS-AHEQVALLTAQPLLAGSVYTVIITYAANLSENFHGFYKSTYRTQEG 161

  Fly   159 NLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAISNMP--EKETKPHETLADYI 221
            . .:.::.|||||.:||:||||||||..||.|.:.:....::.||||||  :..|.....:.|:
  Rat   162 E-RRILAATQFEPTAARMAFPCFDEPALKASFSIKIKRDPRHLAISNMPLVKSVTVAEGLIEDH- 224

  Fly   222 WCEFQESVPMSTYLVAYSVNDFSHKPSTLPNSALFRTWARPNAIDQCDYAAQFGPKVLQYYEQFF 286
               |..:|.|||||||:.::||........:......:|.|:.|:|.|||......:|::||.:|
  Rat   225 ---FDITVKMSTYLVAFIISDFKSVSKMTKSGVKVSVYAVPDKINQADYALDAAVTLLEFYEDYF 286

  Fly   287 GIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAHSSLADKQRVASVVAHELAHQWFGN 351
            .|.:||||.|..|:|||.:||||||||.||||.||||....||.:.|..:...|:||||||||||
  Rat   287 SIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLYDKEKSSASSKLGITMTVSHELAHQWFGN 351

  Fly   352 LVTMKWWTDLWLNEGFATYVASLGVENINPEWRSM---------EQESLS--------------- 392
            ||||:||.|||||||||.::..:.|...:||.:.|         |.|.||
  Rat   352 LVTMEWWNDLWLNEGFAKFMEFVSVTVTHPELKVMQILTANHQNEPEDLSGRAMERTEEEYFFGK 416

  Fly   393 --NLLTIFRRDALESSHPISRPIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYL 455
              |.:.:   |||.||||:|.|::..::|.|.||::||:||:.:|.|:..:|..::|:.|:..||
  Rat   417 CFNAMEV---DALNSSHPVSTPVENPAQIREMFDEVSYEKGACILNMLRDYLSADTFKRGIVQYL 478

  Fly   456 QKFSYKNAEQDNLWESL--------TQ-----AAHKYRSLPKSY------DIKSIMDSWTLQTGY 501
            ||:||||.:.::||.|:        ||     .:....|...|:      ||||:|::||||.|:
  Rat   479 QKYSYKNTKNEDLWNSMMHICPTDGTQTMDGFCSRNQHSSSTSHWRQEVIDIKSMMNTWTLQKGF 543

  Fly   502 PVINVTRDYAARTAKLNQERYLLNTQVARAYRGGCWWVPLSYTT---QAVQDFNNTAPKAWMECG 563
            |:|.:|  ...|...|.||.|:..:: .....|..|.|||::.|   .:||.|
  Rat   544 PLITIT--VRGRNVHLKQEHYMKGSE-CFPETGSLWHVPLTFITSKSDSVQRF------------ 593

  Fly   564 KNGESLPKTIQD---LPGPDQWVIFNTQLSTLYKVNYDAQNWKLLIETLTNGDFERIHVI----N 621
                 |.||..|   ||...:|:.||..::..|.|:|....|..|     ||..:..|..    :
  Rat   594 -----LLKTKTDVIILPEAVEWIKFNVGMNGYYIVHYGDDGWASL-----NGLLKEAHTTISSND 648

  Fly   622 RAQLIDDALYLAWTGEQDYEIAMRLIEYLQREREYLPWKSAFENLKRVGRIVRQTPDFEF---FK 683
            ||.||::|..|...|:...|.|:.||.||:.|.|.:|.......|..:.:::.:....|.   ||
  Rat   649 RASLINNAFQLVSIGKLSIEKALDLILYLKNETEIMPIFQGLNELIPMYKLMEKRDMVEVETQFK 713

  Fly   684 RYMKKLILPIYEHLNGIN-DTFSAIPQQDQVLLKTMVVNWACQYQVGDCVPQALAYYRNWRAEAN 747
            .::.:|:..:      || .|::......:.:|::.::..||.::...||.:|..|:|.|:|.
  Rat   714 DFLLRLLKDL------INKQTWTDEGSVSERMLRSQLLLLACVHRYQLCVQRAERYFREWKAS-- 770

  Fly   748 PDEKNPVPINVRSTVYCTSIKHGSDSDWEFLWTRYKKSNVAAEKRTILTALGCSREVWLLQRYLE 812
             :....:||:|...|:....:  :...|:||:::|:.|..:.||..|..:|..|::...||..|:
  Rat   771 -NGNMSLPIDVTLAVFAVGAQ--NTEGWDFLYSKYQSSLSSTEKSQIEFSLCISQDPEKLQWLLD 832

  Fly   813 LTFDPKEAIRKQDSMWAFQAVAFNEVGFLLAKKYFMDNVDFIYKFYHPLTKDMSRLLSPLSEQVI 877
            .:| ..|.|:.|:.......:..|.||:.||.|:..:|.:.|.:.:...:..::.::...:.|..
  Rat   833 QSF-KGEIIKTQEFPHILTLIGRNPVGYPLAWKFLKENWNKIVQKFELGSSSIAHMVMGTTNQFS 896

  Fly   878 TLSDFNEFKDFVNNSRQSLKGLEQAIQQTLEIMLTNVQWKERNYHQ----MSRSIQQLL 932
            |.:...|.|.|.::.:::...| :.:|||:|.:..|::|.::|:.:    :.:..|:||
  Rat   897 TRARLEEVKGFFSSLKKNGSQL-RCVQQTIETIEENIRWMDKNFDKIRLWLQKERQELL 954

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_652618.1	M1_APN-Q_like	42..497	CDD:341064	190/501 (38%)
		ERAP1_C	582..910	CDD:463368	84/335 (25%)
Erap1	XP_006231762.1	M1_APN-Q_like	50..539	CDD:341064	190/502 (38%)
		ERAP1_C	610..929	CDD:463368	84/336 (25%)