DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and ERAP2

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_001123612.1	Gene:	ERAP2 / 64167	HGNCID:	29499	Length:	960	Species:	Homo sapiens

Alignment Length:	950	Identity:	308/950 - (32%)
Similarity:	475/950 - (50%)	Gaps:	94/950 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 TADSSADSIETT-----YNYYRLPTSLRPQKYHLRI---LTLLENPEDLRFSGSVKILIEALENT 73
            |.|..|..:.|.     :...|||:.:.|..|.|.:   ||.|:      |..|.||.:.....|
Human    47 TEDPGAFPVATNGERFPWQELRLPSVVIPLHYDLFVHPNLTSLD------FVASEKIEVLVSNAT 105

  Fly    74 KNVTLHSKNLTIDESQITLRQIG---GEGKKENCVSSTAVNPSHDFYILNTCQELLAGNTYELYM 135
            :.:.||||:|.|..:.:...:..   ..||:...:|    .|:|:...|...::|.....|.:.|
Human   106 QFIILHSKDLEITNATLQSEEDSRYMKPGKELKVLS----YPAHEQIALLVPEKLTPHLKYYVAM 166

  Fly   136 PFAADLNRQLEGYYRSSYKDPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKY 200
            .|.|.|....||:|:|:|: .:...|:.::||.|||..||:||||||||.|||.|.:.:....::
Human   167 DFQAKLGDGFEGFYKSTYR-TLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRH 230

  Fly   201 TAISNMPEKETKPHE--TLADYIWCEFQESVPMSTYLVAYSVNDFSHKPSTLPNSAL-FRTWARP 262
            .|:||||:.:|...|  .|.|:    |:.:|.||||||||.|.|| |..|...:|.: ...:|.|
Human   231 IALSNMPKVKTIELEGGLLEDH----FETTVKMSTYLVAYIVCDF-HSLSGFTSSGVKVSIYASP 290

  Fly   263 NAIDQCDYAAQFGPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAH 327
            :..:|..||.|...|:|.:||::|.|.:||.|:|.||:|||:.||||||||:||||.:||:....
Human   291 DKRNQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDPKT 355

  Fly   328 SSLADKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWRSMEQESLS 392
            ||.:||..|..|:|||||||||||||||:||.|:||.||||.|:..:.|....||.: .:...|:
Human   356 SSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPELQ-FDDYFLN 419

  Fly   393 NLLTIFRRDALESSHPISRPIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQK 457
            ....:..:|:|.||.|||:|.:..::|.|.||::||.||:.:|.|:..|||||.|:.|:..||:|
Human   420 VCFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQYLKK 484

  Fly   458 FSYKNAEQDNLWESLTQA-------------------AHKYRSLPKSYDIKSIMDSWTLQTGYPV 503
            |||:||:.|:||.||:.:                   ::....|.::.::|.:|.:||||.|.|:
Human   485 FSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMMTTWTLQKGIPL 549

  Fly   504 INVTRDYAARTAKLNQERYLLNT-QVARAYRG----GCWWVPLSYTTQAVQDFNNTAPKAWMECG 563
            :.|.:|  ..:.:|.|||:|... |....:|.    ..|.:||:|:|.:....:....|:
Human   550 LVVKQD--GCSLRLQQERFLQGVFQEDPEWRALQERYLWHIPLTYSTSSSNVIHRHILKS----- 607

  Fly   564 KNGESLPKT-IQDLPGPDQWVIFNTQLSTLYKVNYDAQNWKLLIETLTNGDFERIHVINRAQLID 627
                   || ..|||....||.||...:..|.|:|:...|..|| |..|.:...:...:|..||.
Human   608 -------KTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLI-TQLNQNHTLLRPKDRVGLIH 664

  Fly   628 DALYLAWTGEQDYEIAMRLIEYLQRER------EYLPWKSAFENLKRVGRIVRQTPDF-EFFKRY 685
            |...|...|....:.|:.:..|||.|.      |.|.:..:|.::  :.|  |...|. |..|||
Human   665 DVFQLVGAGRLTLDKALDMTYYLQHETSSPALLEGLSYLESFYHM--MDR--RNISDISENLKRY 725

  Fly   686 MKKLILPIYEHLNGINDTFSAIPQQDQVLLKTMVVNWACQYQVGDCVPQALAYYRNWRAEANPDE 750
            :.:...|:.:. ...:|..|...:    :|::.::..||......|:.:|...:..|...:.
Human   726 LLQYFKPVIDR-QSWSDKGSVWDR----MLRSALLKLACDLNHAPCIQKAAELFSQWMESSG--- 782

  Fly   751 KNPVPINVRSTVYCTSIKHGSDSDWEFLWTRYKKSNVAAEKRTILTALGCSREVWLLQRYLELTF 815
            |..:|.:|...||  |:...:.:.|.:|..:|:.|..:||:..||.||..|:....|.:.:||..
Human   783 KLNIPTDVLKIVY--SVGAQTTAGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKLIELGM 845

  Fly   816 DPKEAIRKQDSMWAFQAVAFNEVGFLLAKKYFMDNVDFIYKFYHPLTKDMSRLLSPLSEQVITLS 880
            :.| .|:.|:......|:|....|..||..:..:|...:.|.:...:.|:..::|..:....:..
Human   846 EGK-VIKTQNLAALLHAIARRPKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIISGTTAHFSSKD 909

  Fly   881 DFNEFKDFVNNSRQSLKGLEQAIQQTLEIMLTNVQWKERN 920
            ...|.|.|..:.......|: ..|..||.:..|::|.|:|
Human   910 KLQEVKLFFESLEAQGSHLD-IFQTVLETITKNIKWLEKN 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	166/406 (41%)
		M1_APN_2	43..502	CDD:189008	194/486 (40%)
		ERAP1_C	583..908	CDD:288671	78/331 (24%)
ERAP2	NP_001123612.1	Peptidase_M1	68..458	CDD:279741	166/406 (41%)
		M1_APN_2	76..548	CDD:189008	194/488 (40%)
		Substrate binding	334..338		3/3 (100%)
		ERAP1_C	621..938	CDD:288671	80/333 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155363
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.750