Protein Alignment SP1029 and ERAP2

DIOPT Version :10

• Sequence 1: NP_652618.1
• Gene: SP1029 / 53473
• FlyBaseID: FBgn0263236
• Length: 932
• Species: Drosophila melanogaster
• Sequence 2: NP_071745.1
• Gene: ERAP2 / 64167
• HGNCID: 29499
• Length: 960
• Species: Homo sapiens
• Alignment Length: 950
• Identity: 308/950 - (32%)
• Similarity: 475/950 - (50%)
• Gaps: 94/950 - (9%)

  Fly    17 TADSSADSIETT-----YNYYRLPTSLRPQKYHLRI---LTLLENPEDLRFSGSVKILIEALENT 73
            |.|..|..:.|.     :...|||:.:.|..|.|.:   ||.|:      |..|.||.:.....|
Human    47 TEDPGAFPVATNGERFPWQELRLPSVVIPLHYDLFVHPNLTSLD------FVASEKIEVLVSNAT 105

  Fly    74 KNVTLHSKNLTIDESQITLRQIG---GEGKKENCVSSTAVNPSHDFYILNTCQELLAGNTYELYM 135
            :.:.||||:|.|..:.:...:..   ..||:...:|    .|:|:...|...::|.....|.:.|
Human   106 QFIILHSKDLEITNATLQSEEDSRYMKPGKELKVLS----YPAHEQIALLVPEKLTPHLKYYVAM 166

  Fly   136 PFAADLNRQLEGYYRSSYKDPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKY 200
            .|.|.|....||:|:|:|: .:...|:.::||.|||..||:||||||||.|||.|.:.:....::
Human   167 DFQAKLGDGFEGFYKSTYR-TLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRH 230

  Fly   201 TAISNMPEKETKPHE--TLADYIWCEFQESVPMSTYLVAYSVNDFSHKPSTLPNSAL-FRTWARP 262
            .|:||||:.:|...|  .|.|:    |:.:|.||||||||.|.|| |..|...:|.: ...:|.|
Human   231 IALSNMPKVKTIELEGGLLEDH----FETTVKMSTYLVAYIVCDF-HSLSGFTSSGVKVSIYASP 290

  Fly   263 NAIDQCDYAAQFGPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAH 327
            :..:|..||.|...|:|.:||::|.|.:||.|:|.||:|||:.||||||||:||||.:||:....
Human   291 DKRNQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDPKT 355

  Fly   328 SSLADKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWRSMEQESLS 392
            ||.:||..|..|:|||||||||||||||:||.|:||.||||.|:..:.|....||.: .:...|:
Human   356 SSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPELQ-FDDYFLN 419

  Fly   393 NLLTIFRRDALESSHPISRPIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQK 457
            ....:..:|:|.||.|||:|.:..::|.|.||::||.||:.:|.|:..|||||.|:.|:..||:|
Human   420 VCFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQYLKK 484

  Fly   458 FSYKNAEQDNLWESLTQA-------------------AHKYRSLPKSYDIKSIMDSWTLQTGYPV 503
            |||:||:.|:||.||:.:                   ::....|.::.::|.:|.:||||.|.|:
Human   485 FSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMMTTWTLQKGIPL 549

  Fly   504 INVTRDYAARTAKLNQERYLLNT-QVARAYRG----GCWWVPLSYTTQAVQDFNNTAPKAWMECG 563
            :.|.:|  ..:.:|.|||:|... |....:|.    ..|.:||:|:|.:....:....|:
Human   550 LVVKQD--GCSLRLQQERFLQGVFQEDPEWRALQERYLWHIPLTYSTSSSNVIHRHILKS----- 607

  Fly   564 KNGESLPKT-IQDLPGPDQWVIFNTQLSTLYKVNYDAQNWKLLIETLTNGDFERIHVINRAQLID 627
                   || ..|||....||.||...:..|.|:|:...|..|| |..|.:...:...:|..||.
Human   608 -------KTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLI-TQLNQNHTLLRPKDRVGLIH 664

  Fly   628 DALYLAWTGEQDYEIAMRLIEYLQRER------EYLPWKSAFENLKRVGRIVRQTPDF-EFFKRY 685
            |...|...|....:.|:.:..|||.|.      |.|.:..:|.::  :.|  |...|. |..|||
Human   665 DVFQLVGAGRLTLDKALDMTYYLQHETSSPALLEGLSYLESFYHM--MDR--RNISDISENLKRY 725

  Fly   686 MKKLILPIYEHLNGINDTFSAIPQQDQVLLKTMVVNWACQYQVGDCVPQALAYYRNWRAEANPDE 750
            :.:...|:.:. ...:|..|...:    :|::.::..||......|:.:|...:..|...:.
Human   726 LLQYFKPVIDR-QSWSDKGSVWDR----MLRSALLKLACDLNHAPCIQKAAELFSQWMESSG--- 782

  Fly   751 KNPVPINVRSTVYCTSIKHGSDSDWEFLWTRYKKSNVAAEKRTILTALGCSREVWLLQRYLELTF 815
            |..:|.:|...||  |:...:.:.|.:|..:|:.|..:||:..||.||..|:....|.:.:||..
Human   783 KLNIPTDVLKIVY--SVGAQTTAGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKLIELGM 845

  Fly   816 DPKEAIRKQDSMWAFQAVAFNEVGFLLAKKYFMDNVDFIYKFYHPLTKDMSRLLSPLSEQVITLS 880
            :.| .|:.|:......|:|....|..||..:..:|...:.|.:...:.|:..::|..:....:..
Human   846 EGK-VIKTQNLAALLHAIARRPKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIISGTTAHFSSKD 909

  Fly   881 DFNEFKDFVNNSRQSLKGLEQAIQQTLEIMLTNVQWKERN 920
            ...|.|.|..:.......|: ..|..||.:..|::|.|:|
Human   910 KLQEVKLFFESLEAQGSHLD-IFQTVLETITKNIKWLEKN 948

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_652618.1	M1_APN-Q_like	42..497	CDD:341064	190/482 (39%)
		ERAP1_C	582..910	CDD:463368	81/334 (24%)
ERAP2	NP_071745.1	M1_APN-Q_like	76..543	CDD:341064	190/483 (39%)
		ERAP1_C	620..938	CDD:463368	81/334 (24%)