DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SP1029 and erap1a

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	XP_009303348.1	Gene:	erap1a / 564068	ZFINID:	ZDB-GENE-091113-7	Length:	933	Species:	Danio rerio

Alignment Length:	978	Identity:	315/978 - (32%)
Similarity:	476/978 - (48%)	Gaps:	122/978 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KWFLLFVAAL------GLGLATADSSADSIETTYNYYRLPTSLRPQKYHLRILTLLENPEDLRFS 60
            |:|...:.||      |....|.:.:...:...::..|||..::||.|.|.|   ..|...|.|:
Zfish     6 KYFHFTLVALFCALFAGNHAMTVNKNKTVLPFPWDKMRLPEIVKPQHYDLLI---HPNLTSLTFT 67

  Fly    61 GSVKILIEALENTKNVTLHSKNLTIDESQITLRQIGGEGKKENCVSSTAVNPSHDFYILN-TCQE 124
            |.|:|.||..::|:.:.||||||.:.::.:.       |.:::       :...|..|.. ...|
Zfish    68 GEVQIQIEVKQDTRAIILHSKNLQVSKALLL-------GSRQH-------HHHQDLQISEFEANE 118

  Fly   125 LLA----GNTYE-----LYMPFAADLNRQLEGYYRSSYKDPVANLTKWISVTQFEPASARLAFPC 180
            .:|    |.|:|     :::.|.|:|:....|:|:..|......: :.::.|||||..||.||||
Zfish   119 QIALFSEGFTFEKGSHVVHLEFYANLSDSFHGFYKGQYTTNSGEV-RMLASTQFEPTHARAAFPC 182

  Fly   181 FDEPDFKAPFVVTLGYHKKYTAISNMPEKETKPHETLADYIW-CEFQESVPMSTYLVAYSVNDFS 244
            ||||.|||.|.:.:....::.:|||||:..|   ..|||.|. .:|...|.|||||||:.:.||.
Zfish   183 FDEPAFKANFTIRVRRESRHISISNMPKLRT---VELADGILEDQFDTMVKMSTYLVAFIICDFH 244

  Fly   245 HKPSTLPNSALFRTWARPNAIDQCDYAAQFGPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAME 309
            .......:......:..|..|.|.:||......:|.:|:::|.|.:||||.|..|:|||.:||||
Zfish   245 SISKKSQHGVEISVYTVPEKISQAEYALDTAVTMLDFYDEYFDIPYPLPKHDLAAIPDFQSGAME 309

  Fly   310 NWGLVTYREIALLYSAAHSSLADKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASL 374
            ||||.||||..||:....||.:||..:..|:|||||||||||||||:||.|||||||||.::..:
Zfish   310 NWGLSTYRESGLLFDPEKSSSSDKLGITKVIAHELAHQWFGNLVTMQWWNDLWLNEGFAKFMEYV 374

  Fly   375 GVENINPEWRSMEQESLSNLLTIFRRDALESSHPISRPIQMVSEISESFDQISYQKGSTVLRMMH 439
            .|...:||.: :....|....|....|:|.||||:|.|::..:||||.||.:||:||:.:|.|:.
Zfish   375 SVNITHPELQ-VNDYFLEKCFTALSVDSLSSSHPVSTPVENPAEISEMFDDVSYRKGACILNMLR 438

  Fly   440 LFLGEESFRSGLQAYLQKFSYKNAEQDNLWESLTQ-------------------------AAHKY 479
            .||..|.|:.|:..||:|.||:|....:||||||.                         .|.|:
Zfish   439 DFLTPEVFKYGIINYLKKHSYQNTVNSHLWESLTNICTSDGLDSGRLKLDGFCSKHTAETPASKW 503

  Fly   480 RSLPKSYDIKSIMDSWTLQTGYPVINVTRDYAARTAKLNQERYLLNTQVARAYRGGCWWVPLSYT 544
            .. ..|.|:.:|||:||||.|:|:|.|  :...:...|.|||:|...:.:.: ....|.|||:|.
Zfish   504 FK-EDSVDVGAIMDTWTLQEGFPLITV--EVKGQEVTLKQERFLKGAESSNS-SSFLWQVPLTYI 564

  Fly   545 T---QAVQDFNNTAPKAWMECGKNGESLPKTIQD---LPGPDQWVIFNTQLSTLYKVNYDAQNWK 603
            |   .|||.|                 |.||.:|   ||...:|:.||..|...|.|:|::..|.
Zfish   565 TSGSNAVQRF-----------------LLKTERDVFYLPEKVEWIKFNVDLRGYYIVHYESGGWD 612

  Fly   604 LLIETLTNGDFERIHVI----NRAQLIDDALYLAWTGEQDYEIAMRLIEYLQREREYLPWKSAFE 664
            .||:.|...     |.:    :||.||.|...|....:...:.|:.|..||.:|.|.:|....|.
Zfish   613 CLIKQLRMN-----HTVFSSNDRASLIHDIFQLVSIEKVPLDKALNLSLYLSKESEIMPVTQGFS 672

  Fly   665 NLKRVGRIVRQTPDFEF---FKRYMKKLILPIYEHLNGINDTFSAIPQQDQVLLKTMVVNWACQY 726
            .|..:.:::.:....|.   .|.::.||..|:.:     ..::|......:.:|:..::.:||..
Zfish   673 ELVPLYKLMEKRDMQELENQLKSHLVKLFQPLID-----RQSWSDNGSVSERMLRNYLLLFACVR 732

  Fly   727 QVGDCVPQALAYYRNWRAEANPDEKNPVPINVRSTVYCTSIKHGSDSDWEFLWTRYKKSNVAAEK 791
            :...||..|...:..|:   ..|.|..:|.:|...||....:  :|..|:||..:||:|...:||
Zfish   733 RYPSCVSTATQLFHKWK---ESDGKMWLPTDVSLVVYTEGAR--TDDGWDFLLEKYKRSVSPSEK 792

  Fly   792 RTILTALGCS----REVWLLQRYLELTFDPKEAIRKQDSMWAFQAVAFNEVGFLLAKKYFMDNVD 852
            ..|..||..|    :..|||:|..|     .|.::.||......:|:.|..||.||..:...|..
Zfish   793 WMIKAALSYSPLAHKLQWLLERSSE-----GEIMKTQDLPSMLISVSKNPKGFKLAWDFLKSNWG 852

  Fly   853 FIYKFYHPLTKDMSRLLSPLSEQVITLSDFNEFKDFVNNSRQSLKGLEQAIQQTLEIMLTNVQWK 917
            .:.|.:...:..:||::..:::|..|....:|.:.|..:..|......::|||.||.:..|:.|.
Zfish   853 KLVKKFDLGSSAISRVVVGVTDQYSTKEMLDEVELFFGSLAQDQGSGLRSIQQALEKIQQNILWM 917

  Fly   918 ERN 920
            :||
Zfish   918 DRN 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	161/408 (39%)
		M1_APN_2	43..502	CDD:189008	189/494 (38%)
		ERAP1_C	583..908	CDD:288671	84/335 (25%)
erap1a	XP_009303348.1	Peptidase_M1	43..430	CDD:279741	161/408 (39%)
		M1_APN_2	52..525	CDD:189008	189/495 (38%)
		ERAP1_C	592..909	CDD:288671	85/336 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590537
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.750