DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and anpepa

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_001038326.1	Gene:	anpepa / 558452	ZFINID:	ZDB-GENE-030131-4781	Length:	946	Species:	Danio rerio

Alignment Length:	932	Identity:	298/932 - (31%)
Similarity:	469/932 - (50%)	Gaps:	104/932 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 RLPTSLRPQKYHLRI-------LTLLENPEDLRFSGSVKILIEALENTKNVTLHSKNLTIDESQI 90
            |||.||.|:.|::.:       :|.....:...|:|:..:.:...:.:..|.||..|:.:...::
Zfish    63 RLPDSLIPESYNVFLQPYLYAAITNNYTEQSYLFTGNSTVRVNCTKTSSRVFLHVHNINVTAVEV 127

  Fly    91 ----TLRQIGGEG----KKENCVSSTAVNPSHDFYILNTCQELLAGNTYELYMPFAADLNRQLEG 147
                |..::..:|    |.|.           :|..::....:....||:::..|..:|...|.|
Zfish   128 RKSDTNEKLPLKGYQIFKNET-----------NFLDIHLEVAIKENGTYDIFTEFEGELLEDLTG 181

  Fly   148 YYRSSY-------KDPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAISN 205
            :|.|.|       :|.    .::::.:..:|..||..|||||||..||.|.:|:.:..:..|.||
Zfish   182 FYASRYTGKGTDDEDE----ERFLATSLLQPTDARTVFPCFDEPAMKAVFTITIIHRPEIRARSN 242

  Fly   206 MPEKETKPHETL----ADYIWCEFQESVPMSTYLVAYSVNDFSHKPSTLPNSALFRT----WARP 262
                |.....|:    .|:|...|:.:..||:||:.:.:.| :|..|.:....  ||    ..|.
Zfish   243 ----EDGDPRTIQINGTDWIRTTFKPTKKMSSYLLGFIIYD-THTFSYVSKGT--RTKIHVHGRS 300

  Fly   263 NAID--QCDYAAQFGPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSA 325
            .|||  ..|||.:....:|.:||..||:::|:.||||||:|||...||||||.::|:|..|||..
Zfish   301 EAIDAGHADYALETTETILSHYENIFGLRYPMSKIDQIALPDFGVRAMENWGFISYQESGLLYDK 365

  Fly   326 AHSSLADKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWRSMEQES 390
            ..:|..|:::|.:::|||||||||||||||.||.||||.||||||::..|||.:.  |...:...
Zfish   366 ETASTFDEEQVTTLIAHELAHQWFGNLVTMSWWNDLWLKEGFATYMSYKGVEAVG--WDLKDLIV 428

  Fly   391 LSNLLTIFRRDALESSHPISR---PIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQ 452
            |..:.|.|:.|:|.:|||:|.   .:|..|:|||.||.|:|.||:.||||:...:||..|..|::
Zfish   429 LREIQTAFQMDSLNTSHPLSMNAYDVQTSSQISELFDDITYSKGAAVLRMLATRMGENEFMKGVK 493

  Fly   453 AYLQKFSYKNAEQDNLWESLTQAAHKYRSLPKSYDIKSIMDSWTLQTGYPVINVTRDYAARTAKL 517
            .||.||.::|....:|||.|....|        ..:...|.:||.:.||||:.:..|    |...
Zfish   494 MYLSKFQFENTVPKDLWECLNMDTH--------IKVDEFMKTWTEEVGYPVLTIITD----TGDT 546

  Fly   518 NQERYLLNTQVARAYRGG---CWWVPLSYTT--QAVQDFNNTAPKAWMECGKNGESLPKTIQDLP 577
            :||::||..:      ||   .|.:|:.|.|  ..|::|    |..:.:.|      |..|.|..
Zfish   547 SQEQFLLKKE------GGHDSLWHIPIKYMTLKAGVKEF----PNFFTDKG------PDPIPDFK 595

  Fly   578 -GPDQWVIFNTQLSTLYKVNYDAQNWKLLIETLTNGDFERIHVINRAQLIDDALYLAWTGEQDYE 641
             |.|.|::.|...:..|:||||.:||..|...|.. :...|.:|||.||||||..||.....:..
Zfish   596 IGKDNWLLANINCTGFYRVNYDEENWNRLTAQLQK-NHRIIPLINRGQLIDDAFNLARAHRLNVT 659

  Fly   642 IAMRLIEYLQREREYLPWKSAFENLKRVGRIVRQTPDFEFFKRYMKKLILPIYEHLN--GINDTF 704
            ||:.|.:||..:.||:||:||.:||.....:..::..:....:|::.|:.|:||...  .||.|.
Zfish   660 IALNLTKYLINDLEYIPWESALKNLDFFTLMFDRSEVYGPIMKYLRNLVTPLYEEYEEYTINGTI 724

  Fly   705 SAIPQQDQVLLKTMVVNWACQYQVGDCVPQALAYYRNWRAEANPDEKNPVPINVRSTVYCTSIKH 769
            ......|| ..:...:..||...:.:|:..|...:.:::     :..||:..|:|..|||:::..
Zfish   725 PIEKYTDQ-CNQVNAITVACSNGLPECITMAKDLFSDYK-----NGSNPIHPNLRRAVYCSAVAS 783

  Fly   770 GSDSDWEFLWTRYKKSNVAAEKRTILTALGCSREVWLLQRYLELTFDPKEAIRKQDSMWAFQAVA 834
            |.:.|||::|..|:|:.|||||..:..||.|::|:|||.|||:.|.:|.: |||.|.:.....:|
Zfish   784 GDEDDWEYVWEEYQKATVAAEKDKLRYALSCTKEIWLLNRYLQYTLEPSK-IRKMDMVSTISYIA 847

  Fly   835 FNEVGFLLAKKYFMDNVDFIYKFYHPLTKDMSRLLSPLSEQVITLSDFNEFKDFVNNSRQSLKGL 899
            .|..|..||..:...:..:|.:.|......:..||..::::..|..:..|.|.......|..|.:
Zfish   848 QNVAGQPLAWDFIRGHWSYITQEYGAGIISLGSLLDVVTKRFSTEVELEELKQLQREQIQDDKWI 912

  Fly   900 -EQAIQQTLEIMLTNVQWKERN 920
             .:|::|.:|....|:.|.:.|
Zfish   913 AARALEQVIERTAANIIWVKEN 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	145/432 (34%)
		M1_APN_2	43..502	CDD:189008	163/493 (33%)
		ERAP1_C	583..908	CDD:288671	100/327 (31%)
anpepa	NP_001038326.1	Peptidase_M1	63..472	CDD:279741	145/432 (34%)
		M1_APN_2	71..535	CDD:189008	163/495 (33%)
		ERAP1_C	602..923	CDD:288671	100/328 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47632
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		mtm6446
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.830