Protein Alignment SP1029 and ERAP1

DIOPT Version :10

• Sequence 1: NP_652618.1
• Gene: SP1029 / 53473
• FlyBaseID: FBgn0263236
• Length: 932
• Species: Drosophila melanogaster
• Sequence 2: XP_005272072.1
• Gene: ERAP1 / 51752
• HGNCID: 18173
• Length: 951
• Species: Homo sapiens
• Alignment Length: 969
• Identity: 305/969 - (31%)
• Similarity: 491/969 - (50%)
• Gaps: 90/969 - (9%)

  Fly     1 MKWFL-----LFVAALGLGLATADSSADSIETT----------YNYYRLPTSLRPQKYHLRILTL 50
            :||.|     |..:.|.|...:..|...|.|.:          :|..|||..:.|..|.|.|..
Human     6 LKWSLATMSFLLSSLLALLTVSTPSWCQSTEASPKRSDGTPFPWNKIRLPEYVIPVHYDLLIHA- 69

  Fly    51 LENPEDLRFSGSVKILIEALENTKNVTLHSKNLTIDESQITLRQIGGEGKKENCVSSTAVNPSHD 115
              |...|.|.|:.|:.|.|.:.|..:.|||.:|.|  |:.|||:..||...|..: ....:|..:
Human    70 --NLTTLTFWGTTKVEITASQPTSTIILHSHHLQI--SRATLRKGAGERLSEEPL-QVLEHPRQE 129

  Fly   116 FYILNTCQELLAGNTYELYMPFAADLNRQLEGYYRSSYKDPVANLTKWISVTQFEPASARLAFPC 180
            ...|...:.||.|..|.:.:.:|.:|:....|:|:|:|:.....| :.::.|||||.:||:||||
Human   130 QIALLAPEPLLVGLPYTVVIHYAGNLSETFHGFYKSTYRTKEGEL-RILASTQFEPTAARMAFPC 193

  Fly   181 FDEPDFKAPFVVTLGYHKKYTAISNMP--EKETKPHETLADYIWCEFQESVPMSTYLVAYSVNDF 243
            ||||.|||.|.:.:....::.||||||  :..|.....:.|:    |..:|.|||||||:.::||
Human   194 FDEPAFKASFSIKIRREPRHLAISNMPLVKSVTVAEGLIEDH----FDVTVKMSTYLVAFIISDF 254

  Fly   244 SHKPSTLPNSALFRTWARPNAIDQCDYAAQFGPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAM 308
            ........:......:|.|:.|:|.|||......:|::||.:|.|.:||||.|..|:|||.:|||
Human   255 ESVSKITKSGVKVSVYAVPDKINQADYALDAAVTLLEFYEDYFSIPYPLPKQDLAAIPDFQSGAM 319

  Fly   309 ENWGLVTYREIALLYSAAHSSLADKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVAS 373
            |||||.||||.|||:.|..||.:.|..:...||||||||||||||||:||.|||||||||.::..
Human   320 ENWGLTTYRESALLFDAEKSSASSKLGITMTVAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEF 384

  Fly   374 LGVENINPEWRSMEQESLSNLLTIFRRDALESSHPISRPIQMVSEISESFDQISYQKGSTVLRMM 438
            :.|...:||.: :..............|||.||||:|.|::..::|.|.||.:||.||:.:|.|:
Human   385 VSVSVTHPELK-VGDYFFGKCFDAMEVDALNSSHPVSTPVENPAQIREMFDDVSYDKGACILNML 448

  Fly   439 HLFLGEESFRSGLQAYLQKFSYKNAEQDNLWESL----------------TQAAHKYRSL---PK 484
            ..:|..::|:||:..||||.||||.:.::||:|:                :::.|...|.   .:
Human   449 REYLSADAFKSGIVQYLQKHSYKNTKNEDLWDSMASICPTDGVKGMDGFCSRSQHSSSSSHWHQE 513

  Fly   485 SYDIKSIMDSWTLQTGYPVINVTRDYAARTAKLNQERYLLNTQVARAYRGGCWWVPLSYTT---Q 546
            ..|:|::|::||||.|:|:|.:|  ...|...:.||.|:..:..| ...|..|.|||::.|   .
Human   514 GVDVKTMMNTWTLQKGFPLITIT--VRGRNVHMKQEHYMKGSDGA-PDTGYLWHVPLTFITSKSD 575

  Fly   547 AVQDFNNTAPKAWMECGKNGESLPKTIQD---LPGPDQWVIFNTQLSTLYKVNYDAQNWKLLIET 608
            .|..|                 |.||..|   ||...:|:.||..::..|.|:|:...|..| ..
Human   576 MVHRF-----------------LLKTKTDVLILPEEVEWIKFNVGMNGYYIVHYEDDGWDSL-TG 622

  Fly   609 LTNGDFERIHVINRAQLIDDALYLAWTGEQDYEIAMRLIEYLQREREYLPWKSAFENLKRVGRIV 673
            |..|....:...:||.||::|..|...|:...|.|:.|..||:.|.|.:|.......|..:.:::
Human   623 LLKGTHTAVSSNDRASLINNAFQLVSIGKLSIEKALDLSLYLKHETEIMPVFQGLNELIPMYKLM 687

  Fly   674 RQTPDFEF---FKRYMKKLILPIYEHLNGINDTFSAIPQQDQVLLKTMVVNWACQYQVGDCVPQA 735
            .:....|.   ||.::.:|:..:.:     ..|::......:.:|::.::..||.:....||.:|
Human   688 EKRDMNEVETQFKAFLIRLLRDLID-----KQTWTDEGSVSERMLRSQLLLLACVHNYQPCVQRA 747

  Fly   736 LAYYRNWRAEANPDEKNPVPINVRSTVYCTSIKHGSDSDWEFLWTRYKKSNVAAEKRTILTALGC 800
            ..|:|.|: |:|.:..  :|::|...|:....:  |...|:||:::|:.|..:.||..|..||..
Human   748 EGYFRKWK-ESNGNLS--LPVDVTLAVFAVGAQ--STEGWDFLYSKYQFSLSSTEKSQIEFALCR 807

  Fly   801 SREVWLLQRYLELTFDPKEAIRKQDSMWAFQAVAFNEVGFLLAKKYFMDNVDFIYKFYHPLTKDM 865
            ::....||..|:.:| ..:.|:.|:.......:..|.||:.||.::...|.:.:.:.:...:..:
Human   808 TQNKEKLQWLLDESF-KGDKIKTQEFPQILTLIGRNPVGYPLAWQFLRKNWNKLVQKFELGSSSI 871

  Fly   866 SRLLSPLSEQVITLSDFNEFKDFVNNSRQSLKGLEQAIQQTLEIMLTNVQWKERNYHQM 924
            :.::...:.|..|.:...|.|.|.::.:::...| :.:|||:|.:..|:.|.::|:.::
Human   872 AHMVMGTTNQFSTRTRLEEVKGFFSSLKENGSQL-RCVQQTIETIEENIGWMDKNFDKI 929

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_652618.1	M1_APN-Q_like	42..497	CDD:341064	184/475 (39%)
		ERAP1_C	582..910	CDD:463368	78/330 (24%)
ERAP1	XP_005272072.1	M1_APN-Q_like	61..526	CDD:341064	184/476 (39%)
		ERAP1_C	597..916	CDD:463368	78/331 (24%)