Protein Alignment SP1029 and Npepps

DIOPT Version :10

• Sequence 1: NP_652618.1
• Gene: SP1029 / 53473
• FlyBaseID: FBgn0263236
• Length: 932
• Species: Drosophila melanogaster
• Sequence 2: NP_536320.1
• Gene: Npepps / 50558
• RGDID: 619962
• Length: 920
• Species: Rattus norvegicus
• Alignment Length: 935
• Identity: 298/935 - (31%)
• Similarity: 465/935 - (49%)
• Gaps: 80/935 - (8%)

  Fly    13 LGLATADSSADSIETTYNYYRLPTSLRPQKYHLRILTLLENPE--DLRFSGSVKILIEALENTKN 75
            ||||.......       :.||||.:.|..|.|.:     .|:  |..|.|.::...:..:.|..
  Rat    41 LGLAAMPEKRP-------FERLPTEVSPINYSLCL-----KPDLLDFTFEGKLEAAAQVRQATNQ 93

  Fly    76 VTLHSKNLTIDESQITLRQIGGEGKKENCVSSTAVN-PSHDFYILNTCQELLAGNTYELYMPFAA 139
            :.::..::.|    || .....||.:|  :.:|..| .:.|..:..:....|...|..|.:.|..
  Rat    94 IVMNCADIDI----IT-ASYAPEGDEE--IHATGFNYQNEDEKVTLSFPSTLQTGTGTLKIDFVG 151

  Fly   140 DLNRQLEGYYRSSYKDPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAIS 204
            :||.:::|:|||.|..| |...::.:|||||...||.||||:|||..||.|.::|...|...|:|
  Rat   152 ELNDKMKGFYRSRYTTP-AGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALS 215

  Fly   205 NMPEKETKPHETLADYIWCEFQESVPMSTYLVAYSVNDFSHKPSTLPNSALFRTWARPNAIDQCD 269
            ||...:.||:....:.:..:|..:..|||||||:.|.::....:...:....|.:......:|..
  Rat   216 NMNVIDRKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGK 280

  Fly   270 YAAQFGPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAHSSLADKQ 334
            :|.:...|.|.:|:.:|.:.:||||||.||:.||:||||||||||||||.|||....:|..:.:|
  Rat   281 FALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQ 345

  Fly   335 RVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWRSMEQESLSNLLTIFR 399
            .||.||.||||||||||||||:|||.||||||||:::..|.|::..||:....|...::......
  Rat   346 WVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQE 410

  Fly   400 RDALESSHPISRPIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQKFSYKNAE 464
            .|||::||||...:...||:.|.||.|||.||::|:||:|.::|::.|:.|:..||.||..|||.
  Rat   411 LDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAA 475

  Fly   465 QDNLWESLTQAAHKYRSLPKSYDIKSIMDSWTLQTGYPVINVTRDYAA--RTAKLNQERYLLNTQ 527
            .::|||||..|:.|        .|.::|::||.|.|:|:|.|..:...  |..||:|:::.
  Rat   476 TEDLWESLESASGK--------PIAAVMNTWTKQMGFPLIYVEAEQVEDDRVLKLSQKKFC---- 528

  Fly   528 VARAYRG-GC--WWVPLSYTTQAVQDFNNTAPKAWMECGKNGESLPKTIQDLPGPDQWVIFNTQL 589
            .:..|.| .|  |.||::.:|.  :|.|....|..|:..:....| |.::    |||||..|...
  Rat   529 ASGPYVGEDCPQWMVPITISTS--EDPNQAKLKILMDKPEMSVVL-KNVK----PDQWVKLNLGT 586

  Fly   590 STLYKVNYDAQNWKLLIETLTNG--DFERIHVINRAQLIDDALYLAWTGEQDYEIAMRLIEYLQR 652
            ...|:..|.:    .::|:|..|  |.. :..::|..|.:|...||..|.......::::|....
  Rat   587 VGFYRTQYSS----AMLESLLPGIRDLS-LPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVN 646

  Fly   653 EREYLPWKSAFENLKRVGRIVRQTPDFEFFKRYMKKLILPIYEHLNGINDTFSAIPQQDQV--LL 715
            |..|..|.....||..:..::..|..:|..:.::|.:..||.|.|.     :...|.:..:  ||
  Rat   647 EPNYTVWSDLSCNLGILSTLLSHTDFYEEIQEFVKDVFSPIGERLG-----WDPKPGEGHLDALL 706

  Fly   716 KTMVVNWACQYQVGDCVPQALAYYRNWRAEANPDEKNPVPINVRSTVYCTSIKHGSDSDWEFLWT 780
            :.:|:.     ::|....:|.......|.:.:.:.|..:..::||.||.|.:|||..:..:.:..
  Rat   707 RGLVLG-----KLGKAGHKATLEEARRRFKEHVEGKQILSADLRSPVYLTVLKHGDGTTLDIMLK 766

  Fly   781 RYKKSNVAAEKRTILTALGCSREVWLLQRYLELTFDPKEAIRKQDSMWAFQAVA-FNEVGFLLAK 844
            .:|::::..||..|...||.:....|:|:.  |||...|.:|.||::.....|| .::.|...|.
  Rat   767 LHKQADMQEEKNRIERVLGATLSPELIQKV--LTFALSEEVRPQDTVSVIGGVAGGSKHGRKAAW 829

  Fly   845 KYFMDNVDFIYKFYHP--LTKDMSRLLSPLSEQVITLSDFNEFKDFVNNSRQSLKGLEQAIQQTL 907
            |:..||.:.:|..|..  |   :|||:....|.........|.|.|..:  ......|:.|||..
  Rat   830 KFIKDNWEELYNRYQGGFL---ISRLIKLSVEGFAVDKMAGEVKAFFES--HPAPSAERTIQQCC 889

  Fly   908 EIMLTNVQWKERNYHQMSRSIQQLL 932
            |.:|.|..|.:|:    :.||.|.|
  Rat   890 ENILLNAAWLKRD----ADSIHQYL 910

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_652618.1	M1_APN-Q_like	42..497	CDD:341064	174/457 (38%)
		ERAP1_C	582..910	CDD:463368	81/334 (24%)
Npepps	NP_536320.1	M1_APN-Q_like	62..500	CDD:341064	174/458 (38%)
		ERAP1_C	579..892	CDD:463368	81/334 (24%)