DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SP1029 and enpep

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_001186660.1	Gene:	enpep / 504088	ZFINID:	ZDB-GENE-050309-218	Length:	951	Species:	Danio rerio

Alignment Length:	962	Identity:	296/962 - (30%)
Similarity:	474/962 - (49%)	Gaps:	107/962 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ALGLGLATADSSADSIETT------------------------YNYYRLPTSLRPQKYHLRILTL 50
            |:|||:..:.:|:...||.                        ::.:|||..:.|..|.|.:
Zfish    33 AVGLGVGLSLNSSSEKETPLPTPLPTEVPDDRPCKPSENTNGGWSNFRLPDYILPFHYDLHM--- 94

  Fly    51 LENPEDLR---FSGSVKILIEALENTKNVTLHSKN--LTIDESQITLRQIGGEGKKENCVSSTAV 110
               ..||.   ::|.|.:.::..:.::::.||.::  :|:..|   |::....|     |:|..:
Zfish    95 ---EPDLNTDIYTGDVSVHLKLTQPSQHLWLHIRDTFVTVMPS---LQRSSPSG-----VTSVKL 148

  Fly   111 NPSHDF----YILNTCQELLA----GNTYELYMPFAADLNRQLEGYYRSSYKDPVANLTKWISVT 167
            ....::    |::....|.|:    ...|.|.:.|...||..|.|:||::|::  ..:||.|:.|
Zfish   149 KQCFEYKPQEYVVVEAAEQLSVTGPDEHYVLTLHFQGWLNGSLVGFYRTTYQE--NGVTKKIAAT 211

  Fly   168 QFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAISNMPEKETKPHETLADY-IWCEFQESVPM 231
            ..||..||.:|||||||:.||.:.:::.:...|.|:||||.::|   |.|::. ....|.:||.|
Zfish   212 DHEPTDARKSFPCFDEPNKKATYTISITHDSTYKALSNMPVEKT---EKLSEQKTKTSFMKSVKM 273

  Fly   232 STYLVAYSVNDFSHKPSTLPNSALFRTWARPNAIDQCDYAAQFGPKVLQYYEQFFGIKFPLPKID 296
            |||||.::|:.|.....|.......|.:|:|..|....|||.....:..|:|::|.:::.:.|:|
Zfish   274 STYLVCFAVHQFDFVERTSKRGIPLRIYAQPLQISTAAYAADVTQVIFDYFEEYFDMEYSIQKLD 338

  Fly   297 QIAVPDFSAGAMENWGLVTYREIALLYSAAHSSLADKQRVASVVAHELAHQWFGNLVTMKWWTDL 361
            :||:|||..||||||||:||||..||:....||..:|||||||:||||.||||||:|||.||.||
Zfish   339 KIAIPDFGTGAMENWGLITYRETNLLFDEKESSSVNKQRVASVIAHELVHQWFGNIVTMDWWDDL 403

  Fly   362 WLNEGFATYVASLGVENINPEWRSMEQESLSNLLTIFRRDALESSHPISRPIQMVSEISESFDQI 426
            |||||||::...:|||....:|...:...::::..:...|||.|||||...:...:||:..||.|
Zfish   404 WLNEGFASFFEYIGVEEAEHDWGMRDVMLINDVYPVMVDDALLSSHPIIVDVSSPAEITSVFDAI 468

  Fly   427 SYQKGSTVLRMMHLFLGEESFRSGLQAYLQKFSYKNAEQDNLWESLTQAAHKYRSLPKSYDIKSI 491
            ||.||:::|||:...||.|:||.|.:.||:.:.::||:..:.|::|...:    .||    :..|
Zfish   469 SYNKGASILRMLEDLLGRETFRDGCRRYLKTYLFQNAKTSDFWKALADES----GLP----VADI 525

  Fly   492 MDSWTLQTGYPVINVTRDYAARTAKLNQERYLLNTQVARAY----RGGCWWVPLSYTTQAVQDFN 552
            ||:||.|.||||:::|.  ....|||.|.|:||:.....:.    .|..|.:|:.:  :|:...|
Zfish   526 MDTWTKQMGYPVLSLTN--TDTEAKLTQTRFLLDPNADPSQPTTPLGYKWTIPVKW--KALDSTN 586

  Fly   553 NT--APKAWMECGKNGES-----LPKTIQDLPGPDQWVIFNTQLSTLYKVNYDAQNWKLLIETLT 610
            |:  ..|...|...:|.|     |.|..:|..|             .|:||:..|.|..:.|.|.
Zfish   587 NSFIFEKGQTEAVISGYSHATNGLIKVNKDHMG-------------FYRVNHHDQMWSDIAEQLL 638

  Fly   611 NGDFERIHVINRAQLIDDALYLAWTGEQDYEIAMRLIEYLQREREYLPWKSAFENLKRVGRIVR- 674
            . |.:.....:|:..|||...|......||..|..|..||..|.||:.|.....::..|..::.
Zfish   639 M-DHQVYDATDRSSYIDDIFALGRADMVDYGNAFNLTRYLADETEYIVWDRVSASISYVREMLAD 702

  Fly   675 QTPDFEFFKRYMKKLILPIYEHLNGINDTFSAIPQQDQVLLKTMVVNWACQYQVGDCVPQALAYY 739
            .|..:..|::..:..:..|...| |..|.    ..|.|.||:.:|:..|||....:.:.||...:
Zfish   703 DTVLYPLFQKLFRGHVQKISREL-GWKDE----GNQTQRLLREIVLGIACQMGDQEALDQASDIF 762

  Fly   740 RNWRAEANPDEKNPVPINVRSTVYCTSIKH-GSDSDWEFLWTRYKKSNVAAEKRTILTALGCSRE 803
            ..|    .......||:|:|..||...:.: |::..||.::.:|..:.:|.||..:|..|...:.
Zfish   763 NKW----IKGTIGSVPVNLRLLVYRYGMMNSGTEESWEIMFQKYLSATLAQEKDKLLYGLASVKN 823

  Fly   804 VWLLQRYLELTFDPKEAIRKQDSMWAFQAVAFNEVGFLLAKKYFMDNVDFIYKFYHPLTKDMSRL 868
            :.||.|.||.|.: :..||.||.....|.|:.:..|.::|..:...|.|::...|....:::.||
Zfish   824 IHLLHRLLEATKN-ESIIRSQDVFTLVQYVSRSSDGKIMAWDWMTLNWDYLVNRYTINDRNLGRL 887

  Fly   869 LSPLSEQVITLSDFNEFKDFVNNSRQSLKGLEQAIQQTLEIMLTNVQWKERN 920
            .:.::....:.....:.:.|......:..| |...:|.||.:..|::|.|||
Zfish   888 PARITTTYSSNLQLWKMEHFFALHPNAGAG-EMPRKQALETVKNNIEWVERN 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	152/411 (37%)
		M1_APN_2	43..502	CDD:189008	174/472 (37%)
		ERAP1_C	583..908	CDD:288671	79/326 (24%)
enpep	NP_001186660.1	Peptidase_M1	80..473	CDD:279741	152/411 (37%)
		M1_APN_2	89..536	CDD:189008	174/473 (37%)
		ERAP1_C	611..927	CDD:288671	83/340 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.920