DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and Lvrn

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	XP_038953134.1	Gene:	Lvrn / 502160	RGDID:	1562779	Length:	993	Species:	Rattus norvegicus

Alignment Length:	894	Identity:	279/894 - (31%)
Similarity:	425/894 - (47%)	Gaps:	105/894 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 YNYYRLPTSLRPQKYHLRILTLLENPED-----LRFSGSVKILIEALENTKNVTLHSKNLTIDES 88
            :::.|||..|.|..|.|.:...|: |::     |.|:|.|.|.:.....|..:.|||..|...:.
  Rat    90 WDHLRLPPWLVPLHYDLELWPRLQ-PDNLSTPSLTFTGRVNITVRCTVATSTLLLHSFFLNYKQV 153

  Fly    89 QI-------TLRQIGGEGKKENCVSSTAVNPSHDFYILNTCQELLAGNTYELYMPFAAD-LNRQL 145
            ::       |.....|....||...:..:    .:.:|:..|.|..|::|||...|:.. |....
  Rat   154 EVWGPLAPDTRNATVGRVPLENVWFALDM----QYVVLDLGQSLDPGSSYELNFDFSGQVLQEGS 214

  Fly   146 EGYYRSSYKDPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAISNMPEKE 210
            ||.:.:.|.|  .:..:.:..||.||..||..|||||||..||.|.:|:.:|..|.|:||||:..
  Rat   215 EGLFLNLYTD--EDQLRALIATQMEPTFARHVFPCFDEPALKATFNITIIHHPGYVALSNMPQLG 277

  Fly   211 TKPHETLADYIW--CEFQESVPMSTYLVAYSVNDFSHKPSTLPNSALFRTWARPNAI--DQCDYA 271
            ......:....|  ..|..:..|.|||||..:.||.:...|.....: |.|||.:.|  ...|:|
  Rat   278 QSHRIDVNGSRWTVTSFHTTPRMPTYLVALVICDFDYVSRTERGKEI-RVWARKDDIADGYLDFA 341

  Fly   272 AQFGPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAHSSLADKQ-R 335
            |.....|..:.|..|.|.:||||.|.||:|.|..||||||||:.:....||  .....|.:|: .
  Rat   342 ANHTGPVFSFLEDLFNISYPLPKTDIIALPTFVNGAMENWGLMIFDASLLL--ELDDDLPEKRAM 404

  Fly   336 VASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWRSMEQESLSNLLTIFRR 400
            :.|:::||:.||||||||||.||.::|||||||:|. .:|:.|.   :......::...||:. .
  Rat   405 ILSILSHEVGHQWFGNLVTMSWWNNIWLNEGFASYF-EVGLTNY---FYPKVPRNMIFFLTVL-H 464

  Fly   401 DALESSH-----PISRPIQMVS---EISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQK 457
            |.||..|     .:|.|::..:   ||:..||..:|:||:.:..|:..||.:..|.:.|::||:.
  Rat   465 DILEDDHSLESRAVSTPVENFTETREINRLFDIYTYKKGACMAWMLAGFLSQHLFINALKSYLET 529

  Fly   458 FSYKNAEQDNLWESLTQAAHKYRSLPKSYDIKSIMDSWTLQTGYPVINVTRDYAARTAKLNQER- 521
            |||.|||||:||..:..|..:...:.....:|.||||||.|:|:|||.:.    |.|..:.||.
  Rat   530 FSYSNAEQDDLWRHIQMAIDEQSIIHLPATVKRIMDSWTHQSGFPVITLN----ASTGVVKQEPF 590

  Fly   522 YLLNTQVARAYRGGCWWVPLSYTTQAVQDFNNTAPKAWMECGKNGESLPKTIQDLPG------PD 580
            ||...:.........|.||:.:....:     |.|..|::         |:....||      ..
  Rat   591 YLERVENQTLLSHNTWIVPIFWMKNGI-----TQPLVWLD---------KSSMIFPGMKLSDSDS 641

  Fly   581 QWVIFNTQLSTLYKVNYDAQNWKLLIETLTNGDFERIHVINRAQLIDDALYLAWTGEQDYEIAMR 645
            .|||.|..::..|:||||...||.|.:.|.. |.:.|.||||.||:.||..|:.....:.|.|:.
  Rat   642 DWVILNFNVTGYYRVNYDKLGWKKLNQQLEK-DPKAIPVINRLQLVSDAFALSKNNYIEIETALD 705

  Fly   646 LIEYLQREREYLPWKSAFENL--KRVGRIVRQTPDFEFFKRYMKKLILPIYEHLNGINDTFSAIP 708
            |.:|:.:|.|.|.|.....||  :.|...|:....:...|:|..|       .||.|...:|||.
  Rat   706 LTKYIAKEDEILVWFEVLVNLINREVVYDVKNYYLYPLLKKYFLK-------RLNSIWTIYSAII 763

  Fly   709 QQDQVLLKTMVVN---------WACQYQVGDCVPQALAYYRNWRAEANPDEKNPVPINVRSTVYC 764
            :::...|:...::         .||...:.||:..:...:|.|.  |:|:  ..:|..:...|.|
  Rat   764 RENMASLQDNFLSLLPLKKFFETACWLGLEDCLQLSRELFRKWM--AHPE--TAIPPQIEKVVLC 824

  Fly   765 TSIKHGSDSDWEFLWTRY-KKSNVAAEKRTILTALGCSREVWLLQRYLE--LTFDPKEAIRKQDS 826
            .:|..||:.||:||:..| .|:....:...::.|:|||::...|.|::|  :|..|.    :.:.
  Rat   825 NAIALGSNKDWDFLFNLYINKTEEQEDLFHLVHAMGCSKDPRTLNRFMEYDITVFPS----RFNE 885

  Fly   827 MWAFQAVAFNEVGFLLAKKYFMDNVDFIYKFYHPLTKDMSRLLSPLSEQ 875
            ....:.||.:|||..:||.:.::|...:|:         |..||||.:|
  Rat   886 TNLIEVVAESEVGRYVAKDFLINNWVAVYE---------SPSLSPLLQQ 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	142/423 (34%)
		M1_APN_2	43..502	CDD:189008	166/484 (34%)
		ERAP1_C	583..908	CDD:288671	89/307 (29%)
Lvrn	XP_038953134.1	M1_APN-Q_like	102..569	CDD:341064	163/481 (34%)
Lvrn	XP_038953134.1	ERAP1_C	643..915	CDD:403137	83/287 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349290
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.940