DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and CG46339

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster

Alignment Length:	929	Identity:	303/929 - (32%)
Similarity:	483/929 - (51%)	Gaps:	72/929 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 RPQKYHL----RILTLLENPEDLRFSGSVKILIE----ALENTKNVTLHSKNLTIDESQITLRQI 95
            ||..|.|    .:.|.:.|       ||:.|.||    .:.:.:.:.|...|::|...::.....
  Fly   295 RPLHYSLLIEPSVATSISN-------GSLTIEIERDVSKVTSWEPIVLDVHNVSISNVRVIRALA 352

  Fly    96 GGEGKKENCVSSTAVNPSHDF----------YILNTCQELLAGNTYE--LYMPFAADLNRQLEGY 148
            .|       .|:.:.....||          :::|..:.|.......  |.:.|.:.:...|:|.
  Fly   353 DG-------ASNASEEQDLDFDSDYGEDNATFVINLSKTLAVETQLRVLLSLDFVSQVTDTLQGI 410

  Fly   149 YRSSYKDPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKY-TAISNMPEKETK 212
            |::||.:|.....:|:..|||.|..||.||||||.||.||.|.:::....:: .|:||||:..::
  Fly   411 YKTSYTNPDTKNEEWMISTQFSPVDARRAFPCFDRPDMKANFSISIVRPMQFKMALSNMPKSGSR 475

  Fly   213 PHETLADYIWCEFQESVPMSTYLVAYSVNDFSHKPSTLPNSAL---FRTWARPNAIDQCDYAAQF 274
            ...  ..:|..:|:.:..|.|||||:.|::.........:|.|   ...|.||..:....||.:.
  Fly   476 RFR--RGFIRDDFETTPKMPTYLVAFIVSNMVDSRLASQDSGLTPRVEIWTRPQFVGMTHYAYKM 538

  Fly   275 GPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYS---AAHSSLADKQRV 336
            ..|.|.|||.|||||..|||||.::||||...|||||||:|:|:.|||..   ...||....|.|
  Fly   539 VRKFLPYYEDFFGIKNKLPKIDLVSVPDFGFAAMENWGLITFRDSALLVPEDLQLASSSEHMQVV 603

  Fly   337 ASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWRSMEQESLSNLLTIFRRD 401
            |.::||||||||||||||.|||.||||.||||.|::...:|:.:||::||:..::.........|
  Fly   604 AGIIAHELAHQWFGNLVTPKWWDDLWLKEGFACYMSYKALEHAHPEFQSMDTLTMLEFKESMEHD 668

  Fly   402 ALESSHPISRPIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQKFSYKNAEQD 466
            |..:||.||..::..:::...||.|||.||:.:|||::..:|:.:|||..:..|:||:|.|.::|
  Fly   669 ADNTSHAISFDVRSTNDVRRIFDPISYSKGTILLRMLNSIVGDVAFRSATRDLLKKFAYGNMDRD 733

  Fly   467 NLWESLTQAAHKYRSLPKSYDIKSIMDSWTLQTGYPVINVTRDYAARTAKLNQERYLLNTQVARA 531
            :||..||:..|:..:|||...:|.|||||..|.||||:||.|..|  ...|.||||||.::  ..
  Fly   734 DLWAMLTRHGHEQGTLPKDLSVKQIMDSWITQPGYPVVNVERRGA--DLVLRQERYLLPSK--NT 794

  Fly   532 YRGGCWWVPLSYTTQAVQDFNNTAPKAWMECGKNGESLPKTI-QDLPGPDQWVIFNTQLSTLYKV 595
            .....|::|:::.|..::..:| .|..||......|.:...: ......|..:..|......|:|
  Fly   795 ADQSTWFIPITFETDELRKGDN-IPTHWMRSEDEEELIVGNVFAHSSNSDNVIYLNLNRQGYYRV 858

  Fly   596 NYDAQNWKLLIETLTNGDFERIHVINRAQLIDDALYLAWTGEQDYEIAMR-LIEYLQREREYLPW 659
            |||..:|..|     ..:|..:..|.||||:||||:|:......|:|.:. |:|......:.|.|
  Fly   859 NYDMTSWLAL-----KKNFSTLPRITRAQLLDDALHLSQAEYLTYDIPLTFLMELFDAVDDELLW 918

  Fly   660 KSAFENLKRVGRIVRQTPDFEFFKRYMKKLILPIYEHLNGINDTFSAIPQQD---QVLLKTMVVN 721
            .:|...|..:...:::.|.:|.|:.:||.::.|.::|. |:::     |..:   |:..:.:|..
  Fly   919 IAAKPGLNYLIYNLKREPAYETFRAFMKFIVRPAFDHY-GLHE-----PDNESHLQLKHRALVAY 977

  Fly   722 WACQYQVGDCVPQALAYYRNWRAEANPDEKNPVPINVRSTVYCTSIKHGSDSDWEFLWTRYKKSN 786
            :||::....|..:|...:|.|..:   .:.||:..|::|.:||||:..||..:|.|.:.:||.:.
  Fly   978 FACKFNYDRCTQKAQMKFREWMRD---PKNNPIKPNLKSVIYCTSLAEGSSPEWYFAYKQYKTTT 1039

  Fly   787 VAAEKRTILTALGCSREVWLLQRYLELTFDPKEAIRKQDSMWAFQAVAFNEVGFLLAKKYFMDNV 851
            .|:||..|||:|||:.:.|||.:||.:|.:|...|.|||...||:|||.|.:|..:|..:...|:
  Fly  1040 SASEKEEILTSLGCTTKPWLLSKYLNMTINPTSGILKQDGALAFRAVASNAIGHEIAFDFLQGNI 1104

  Fly   852 DFIYKFYHPLTKDMSRLLSPLSEQVITLSDFNEFK--DFVNNSRQ-SLKGLEQAIQQTLEIMLTN 913
            ..|.::|......:|.::..|:  :....|:::.:  |.....|: .|..:|.||:..||.:..|
  Fly  1105 KEIVEYYGDGFSTLSEMIKSLT--IYMNKDYHKHQLLDLAATCRKLGLHAVESAIELALEQVNNN 1167

  Fly   914 VQWKERNYHQMSRSIQQLL 932
            :.|:..:||.:...::.::
  Fly  1168 IYWRSHSYHSLKNFLEGIV 1186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	145/418 (35%)
		M1_APN_2	43..502	CDD:189008	174/485 (36%)
		ERAP1_C	583..908	CDD:288671	98/331 (30%)
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	144/417 (35%)
		M1_APN_2	297..769	CDD:189008	174/487 (36%)
		ERAP1_C	846..1138	CDD:288671	92/307 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462079
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10752at50557
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	8	7.850