DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and CG14516

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster

Alignment Length:	974	Identity:	369/974 - (37%)
Similarity:	547/974 - (56%)	Gaps:	92/974 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLFVAALGLGLATA-----DSSADSIETTYNY----------------YRLPTSLRPQKYHLRIL 48
            ||.|..:....||.     ||..|.:.|:|:.                .|||.|:||.||::.|.
  Fly    64 LLAVGFIVYNFATCAELEPDSDEDVVCTSYHLRRLKAGHDDTPKYDRDVRLPHSIRPLKYNITIE 128

  Fly    49 TLLENPEDLRFSGSVKILIEALENTKNVTLHSKNLTIDESQITLRQIGGEGKKEN---CVSSTAV 110
            ..|..  :..|:|||:|.|..||:..|:|:|::.|.|..|..::.::...|:.|.   .:....:
  Fly   129 PQLSG--NFTFAGSVQIRIRVLEDCYNITMHAEELNISRSDASVHRVQNNGEPEGDGLRIHKQYL 191

  Fly   111 NPSHDFYILNTCQELLAGNTYELYMPFAADLNRQLEGYYRSSYKDPVANLTKWISVTQFEPASAR 175
            ..:..|:::....:||....|.:::.|...:...|:|:|||||:  |.|.|:|::.|||:...||
  Fly   192 VGAKQFFVIELYDKLLKDVEYVVHLRFDGIIEDYLQGFYRSSYE--VHNETRWVASTQFQATDAR 254

  Fly   176 LAFPCFDEPDFKAPFVVTLGYHKKYTAISNMPEKETKPHETLADYIWCEFQESVPMSTYLVAYSV 240
            .||||||||..||.|.:.:...:..|.|||||...:..|.|:..|:|..|.||:|||||||||::
  Fly   255 RAFPCFDEPALKANFTLHIARPRNMTTISNMPIVSSNDHATMPSYVWDHFAESLPMSTYLVAYAI 319

  Fly   241 NDFSHKPSTLPNSALFRTWARPNAIDQCDYAAQFGPKVLQYYEQFFGIKFPLPKIDQIAVPDFSA 305
            :||:|     .:|..|..|||.:||...:||...||::|.:.:.||.:.|||||||.||:|:|.|
  Fly   320 SDFTH-----ISSGNFAVWARADAIKSAEYALSVGPRILTFLQDFFNVTFPLPKIDMIALPEFQA 379

  Fly   306 GAMENWGLVTYREIALLYSAAHSSLADKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATY 370
            ||||||||:|:||.|:||....::..:||||||||.|||||||||||||..||:|:|||||||:|
  Fly   380 GAMENWGLITFRETAMLYDPGVATANNKQRVASVVGHELAHQWFGNLVTPSWWSDIWLNEGFASY 444

  Fly   371 VASLGVENINPEWRSMEQESLSNLLTIFRRDALESSHPISRPIQMVSEISESFDQISYQKGSTVL 435
            :..|..:.:.|||:.::|..::.|..:|:.|||.:||.||..:....||||.||:|||.||||::
  Fly   445 MEYLTADAVAPEWKQLDQFVVNELQAVFQLDALSTSHKISHEVFNPQEISEIFDRISYAKGSTII 509

  Fly   436 RMMHLFLGEESFRSGLQAYLQKFSYKNAEQDNLWESLTQAAHKYRSLPKSYDIKSIMDSWTLQTG 500
            |||..||....||.||..|||:.:|.:|.||:||..||..|.....|..|..:|.|||:||||||
  Fly   510 RMMAHFLTNPIFRRGLSKYLQEMAYNSATQDDLWHFLTVEAKSSGLLDDSRSVKEIMDTWTLQTG 574

  Fly   501 YPVINVTRDYAARTAKLNQERYLLNTQVARAYRGGCWWVPLSYTTQAVQDFNNTAPKAWMECGKN 565
            |||:.|:|...:...:|.|.|::. |...|......|::|:::||.:..:|.||.|..||
  Fly   575 YPVVKVSRHPNSDVIRLEQVRFVY-TNTTREDESLLWYIPITFTTDSELNFANTRPTTWM----- 633

  Fly   566 GESLPKT-IQDLPGPD----QWVIFNTQLSTLYKVNYDAQNWKLLIETLTNGD-FERIHVINRAQ 624
                |:| :.:|...:    :|.|||.|.:..|:||||.:||..:.|.|.:.| ||.|...||||
  Fly   634 ----PRTKLYELENRELSLAKWFIFNVQQTGYYRVNYDLENWMAITEHLMDVDNFEDIAPANRAQ 694

  Fly   625 LIDDALYLAWTGEQDYEIAMRLIEYLQREREYLPWKSAFENLKRVGRIVRQTPDFEFFKRYMKKL 689
            ||||.:.||......||.||.|..||..|..::|||:|..|...:..:...:.|::..|.|:.|.
  Fly   695 LIDDVMNLARGSYLSYETAMNLTRYLGHELGHVPWKAAISNFIFIDSMFVNSGDYDLLKNYLLKQ 759

  Fly   690 ILPIYEHLNGINDTFSAIPQQDQVLLKTM---VVNWACQYQVGDCVPQALAYYRNWRAEANPDEK 751
            :..:|:.: |..|:..   :.:.:|:|..   :::.||.....:|:.:|..:::||....|||..
  Fly   760 LKKVYDQV-GFKDSQD---ESEDILVKLKRADILSMACHLGHQECIAEASRHFQNWMQTPNPDSN 820

  Fly   752 NPVPINVRSTVYCTSIKHGSDSDWEFLWTRYKKSNVAAEKRTILTALGCSREVWLLQRYLELTFD 816
            ||:..|:|..|||::|::|::.:|:|.:.|:.|:||..||..:|.|||||:|.|||.|:|.....
  Fly   821 NPIVPNLRGVVYCSAIQYGTEYEWDFAFERFLKTNVPGEKDLLLNALGCSKEPWLLYRFLRRGIS 885

  Fly   817 PKEAIRKQDSMWAFQAVAFNEVGFLLA-----------KKYF---MDNVDFIYKFYHPLTKDMSR 867
            .:. |||||....|.||:...||..:|           |.|.   |.::..::||   .||..:
  Fly   886 GQH-IRKQDLFRVFAAVSTTVVGQNIAFDFLRNNWQEIKTYMGSQMSSIHTLFKF---ATKGFN- 945

  Fly   868 LLSPLSEQVITLSDF--NEFKDFVNNSRQSLKGLEQAIQQTLEIMLTNVQWKERNYHQMSRSIQ 929
                        |.|  .||::||.::...   .::.:||.:|.:.|:|.|..:||..:.|.::
  Fly   946 ------------SKFQLGEFENFVKDAHWD---YDRPVQQIVEHIETSVDWMNKNYKSIVRWLE 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	178/400 (45%)
		M1_APN_2	43..502	CDD:189008	208/461 (45%)
		ERAP1_C	583..908	CDD:288671	113/344 (33%)
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	178/400 (45%)
		M1_APN_2	121..576	CDD:189008	209/463 (45%)
		ERAP1_C	652..974	CDD:288671	113/345 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462070
Domainoid	1	1.000	114	1.000	Domainoid score	I6014
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2057
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10752at50557
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		mtm6446
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	11	10.700