DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SP1029 and npepps

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_001157499.1	Gene:	npepps / 407726	ZFINID:	ZDB-GENE-060524-3	Length:	872	Species:	Danio rerio

Alignment Length:	923	Identity:	294/923 - (31%)
Similarity:	460/923 - (49%)	Gaps:	97/923 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 YYRLPTSLRPQKYHLRILTLLENPE--DLRFSGSVKILIEALENTKNVTLHSKNLTIDESQITLR 93
            :.||||.:.|..|.||:     .|:  |..|.|.::..:|..:.|..:.::..::.|    ||..
Zfish     7 FVRLPTDVYPVNYGLRL-----KPDLVDFTFEGKLEAAVEVTQGTNQIVMNCADIDI----ITAS 62

  Fly    94 QI--GGEGKKENCVSSTAVNPSHDFYILNTC-QELLAGNTYELYMPFAADLNRQLEGYYRSSYKD 155
            .:  |||.     :::|..|..::...:..| ...|...:..|.:.|..:||.:::|:|||.|..
Zfish    63 FVPDGGEE-----INATGFNYQNEDEKVTLCFPSTLQKGSGSLKIDFVGELNDKMKGFYRSKYSS 122

  Fly   156 PVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAISNMPEKETKPHETLADY 220
              :...::.:|||||...||.||||:|||..||.|.:||...|...|:|||...:.||:......
Zfish   123 --SGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDITLIVPKDRVALSNMNVVDRKPYAEDQSL 185

  Fly   221 IWCEFQESVPMSTYLVAYSVNDFSHKPSTLPNSALFRTWARPNAIDQCDYAAQFGPKVLQYYEQF 285
            :..:|..:..|||||||:.:.::....|...:....|.:......:|..:|.:...|.|.:|:.:
Zfish   186 VEVKFATTPIMSTYLVAFVIGEYDFVESQSSDGVTVRVYTPVGKAEQGKFALEVATKTLPFYKDY 250

  Fly   286 FGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAHSSLADKQRVASVVAHELAHQWFG 350
            |.:.:||||||.||:.||:||||||||||||||.|||....:|..:.:|.||.||.|||||||||
Zfish   251 FSVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCASSRQWVALVVGHELAHQWFG 315

  Fly   351 NLVTMKWWTDLWLNEGFATYVASLGVENINPE---WRSMEQESLSNLLTIFRRDALESSHPISRP 412
            |||||:|||.||||||||:::..|.|::..||   |........:..|.:   |||::||||...
Zfish   316 NLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRALDL---DALDNSHPIEVD 377

  Fly   413 IQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQKFSYKNAEQDNLWESLTQAAH 477
            :...||:.|.||.|||.||::|:||:|.::|:|.||.|:.|||.||.:|||..::|||.|.||:.
Zfish   378 VGHPSEVDEIFDAISYSKGASVIRMLHNYIGDEDFRKGMNAYLLKFQHKNASTEDLWECLEQASG 442

  Fly   478 KYRSLPKSYDIKSIMDSWTLQTGYPVINVTRDY--AARTAKLNQERYLLNTQVARAYRG--GC-- 536
            |        .|.::|:|||.|.|:|:|.|.::.  :.|..|::|:::     .|...|.  .|
Zfish   443 K--------PIAAVMNSWTKQMGFPIIVVDQEQHGSDRVLKISQKKF-----CASGPRNDEDCPN 494

  Fly   537 WWVPLSYTTQAVQDFNNTAPKAWMECGKNGESLPKTIQDLP--GPDQWVIFNTQLSTLYKVNYDA 599
            |.||:|..|.  :|.:.|..|..::       .|:|..::.  .||.|:..|......|::.|.:
Zfish   495 WMVPISICTS--EDPSCTKTKILLD-------QPETTVNITNVAPDHWIKINPGTVGFYRIQYSS 550

  Fly   600 QNWKLLIETLTNG--DFERIHVINRAQLIDDALYLAWTGEQDYEIAMRLIEYLQREREYLPWKSA 662
                .::|:|..|  |...:.| :|..|.:|...||..|.......::::|....|..|..|...
Zfish   551 ----AMLESLLPGIRDLTLLPV-DRLGLQNDLFSLARAGMISTVEVLKVMEAFVNEPNYTVWSDL 610

  Fly   663 FENLKRVGRIVRQTPDFEFFKRYMKKLILPIYEHLNGINDTFSAIPQQDQVLLKTMVVNWACQYQ 727
            ..||..:..::..|...|..:.:::.|..||...|..  |:.:.....| .||:.:|:.     :
Zfish   611 SCNLGVLSSLLSHTDFHEDIQEFIRDLFTPIGMKLGW--DSRTGEGHLD-ALLRGLVLG-----K 667

  Fly   728 VGDCVPQALAYYRNWRAEANPDEKNPVPINVRSTVYCTSIKHGSDSDWEFLWTRYKKSNVAAEKR 792
            :|....:|.......|...:.:.|..:..::||.||.|.:|||..:..:.:...:|::::..||.
Zfish   668 LGKAGHKATLEEARRRFREHVEGKQILSADLRSPVYLTVLKHGDSTTLDTMLKLHKQADMQEEKN 732

  Fly   793 TILTALGCSREVWLLQRYLELTFDPKEAIRKQDSMWAFQAVA-FNEVGFLLAKKYFMDNVDFIYK 856
            .|...||......|:||.  |.|...|.:|.||::.....|| .::.|...|.|:..||.:.::.
Zfish   733 RIERVLGAIPAPDLIQRV--LNFALSEEVRPQDTVSVIGGVAGSSKQGRKAAWKFVKDNWEELHN 795

  Fly   857 FYHP--LTKDMSRLLSPLSEQVITLSDF------NEFKDFVNNSRQSLKGLEQAIQQTLEIMLTN 913
            .|..  |   :|||:.      :|:..|      .|.|.|..:  ......|:.:||..|.:|.|
Zfish   796 RYQGGFL---ISRLIK------LTVDGFAIDKMAAEVKSFFES--HHAPAAERTVQQCCENILLN 849

  Fly   914 VQWKER---NYHQ 923
            ..|.:|   :.||
Zfish   850 AAWLKRDADDIHQ 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	154/405 (38%)
		M1_APN_2	43..502	CDD:189008	182/466 (39%)
		ERAP1_C	583..908	CDD:288671	78/335 (23%)
npepps	NP_001157499.1	Peptidase_M1	9..396	CDD:279741	154/405 (38%)
		M1_APN_2	17..459	CDD:189008	182/468 (39%)
		ERAP1_C	534..845	CDD:288671	78/336 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820