DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SP1029 and LTA4H

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_000886.1	Gene:	LTA4H / 4048	HGNCID:	6710	Length:	611	Species:	Homo sapiens

Alignment Length:	595	Identity:	141/595 - (23%)
Similarity:	236/595 - (39%)	Gaps:	143/595 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PTSL-RPQKYHLRI------LTLLENPEDLRFSGSVKILIEALE-NTKNVTLHSKNLTIDESQIT 91
            |.|: |.:..|||.      .||         :|:..:.:::.| |.:::.|.:|:|||::..|.
Human    13 PASVCRTKHLHLRCSVDFTRRTL---------TGTAALTVQSQEDNLRSLVLDTKDLTIEKVVIN 68

  Fly    92 LRQIGGEGKKENCVSSTAVNPSHDFYILNTCQELLAGNTYELYMPFAADLNRQ--LEGYYRSSYK 154
                |.|.|                |.|...|. ..|:..|:.:|.|...|::  :|..:.:|
Human    69 ----GQEVK----------------YALGERQS-YKGSPMEISLPIALSKNQEIVIEISFETS-- 110

  Fly   155 DPVANLTKWIS------------VTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAI-SNM 206
             |.::..:|::            .:|.:....|...||.|.|..|..:...:...|:..|: |.:
Human   111 -PKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAI 174

  Fly   207 PEKETKPHETLADYIWCEFQESVPMSTYLVAYSVNDFSHK---PSTLPNSALFRTWARPNAIDQC 268
            .:.||...|..:..|: :|.:.||:..||:|..|.....:   |.||       .|:....:::.
Human   175 RDGETPDPEDPSRKIY-KFIQKVPIPCYLIALVVGALESRQIGPRTL-------VWSEKEQVEKS 231

  Fly   269 DYAAQFGPKVLQYYEQFFGIKFPLPKIDQIAV-PDFSAGAMENWGLVTYREIALLYSAAHSSLAD 332
            .|.......:|:..|...| .:...:.|.:.: |.|..|.|||         ..|.....:.||.
Human   232 AYEFSETESMLKIAEDLGG-PYVWGQYDLLVLPPSFPYGGMEN---------PCLTFVTPTLLAG 286

  Fly   333 KQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVA----------------SLGVENINP 381
            .:.:::|:|||::|.|.|||||.|.|...|||||...|:.                :||
Human   287 DKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALG------ 345

  Fly   382 EWRSMEQESLSNLLTIFRRDALESSHPISRPIQMVSEISE--SFDQISYQKGSTVLRMMHLFL-G 443
            .|     ..|.|.:..|     ..:||.::.:..:::|..  ::..:.|:||..:|..:...| |
Human   346 GW-----GELQNSVKTF-----GETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGG 400

  Fly   444 EESFRSGLQAYLQKFSYKNAEQDNLWESLTQAAHKYRSLPKSYDIKSIMD--SWTLQTGYPVINV 506
            .|.|...|:||::|||||:...|: |:...     |.......|:.:.:|  :|....|.|.|
Human   401 PEIFLGFLKAYVEKFSYKSITTDD-WKDFL-----YSYFKDKVDVLNQVDWNAWLYSPGLPPI-- 457

  Fly   507 TRDYAARTAKLNQERYLLNTQVARAYRGGCWWVPLSYTTQAVQDFN--NTAPKAWMECGKNGESL 569
                     |.|.:..|.|..:|.:.|    |:     |....|.|  |......:...:..|.|
Human   458 ---------KPNYDMTLTNACIALSQR----WI-----TAKEDDLNSFNATDLKDLSSHQLNEFL 504

  Fly   570 PKTIQDLPGP 579
            .:|:|..|.|
Human   505 AQTLQRAPLP 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	100/440 (23%)
		M1_APN_2	43..502	CDD:189008	119/505 (24%)
		ERAP1_C	583..908	CDD:288671
LTA4H	NP_000886.1	leuko_A4_hydro	6..608	CDD:274120	141/595 (24%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:18804029	135..137		1/1 (100%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:18804029	267..272		1/4 (25%)
		Inhibitor ARM1 binding. /evidence=ECO:0000269\|PubMed:24591641	362..365		1/2 (50%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:18804029	564..566
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810