DRSC/TRiP Functional Genomics Resources

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Protein Alignment SP1029 and LNPEP

DIOPT Version :9

Sequence 1:NP_001263065.1 Gene:SP1029 / 53473 FlyBaseID:FBgn0263236 Length:932 Species:Drosophila melanogaster
Sequence 2:NP_005566.2 Gene:LNPEP / 4012 HGNCID:6656 Length:1025 Species:Homo sapiens


Alignment Length:905 Identity:296/905 - (32%)
Similarity:480/905 - (53%) Gaps:61/905 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 RLPTSLRPQKYHLRILTLLENPEDLRFSGSVKILIEALENTKNVTLHSKNLTIDESQITLRQIGG 97
            ||||::.|.:|.   |:|..|...:.|.|||.|.::||:.|.|:.|||....|  |::|......
Human   167 RLPTAVVPLRYE---LSLHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNI--SRVTFMSAVS 226

  Fly    98 EGKKENCVSSTAVNPSHDFYILNTCQELLAGNTYELYMPFAADLNRQLEGYYRSSYKDPVANLTK 162
            ..:|:..:...|.   |....:...:.||||:.|.|.:.::|:::....|:|..||.|. :|..|
Human   227 SQEKQAEILEYAY---HGQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDE-SNEKK 287

  Fly   163 WISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAISNMPEKETKPHETLAD-YIWCEFQ 226
            :.:.|||||.:||.||||||||.|||.|::.:...::|||:||||:|.:   ..|.| .:..||.
Human   288 YFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSS---VVLDDGLVQDEFS 349

  Fly   227 ESVPMSTYLVAYSVNDFSHKPSTLPNSALFRTWARPNAIDQCDYAAQFGPKVLQYYEQFFGIKFP 291
            |||.|||||||:.|.:..:....: |..|...:|.|..|.|..||.:...|:|::::.:|.|::|
Human   350 ESVKMSTYLVAFIVGEMKNLSQDV-NGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYP 413

  Fly   292 LPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAHSSLADKQRVASVVAHELAHQWFGNLVTMK 356
            |.|:|.:|:|||.|||||||||:|:||..|||.:..||:||::.|..::||||||||||||||||
Human   414 LKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMK 478

  Fly   357 WWTDLWLNEGFATYVASLGVENINPEWRSMEQESLSNLLTIFRRDALESSHPISRPIQMVSEISE 421
            ||.||||||||||::....:|.|..|..|.| :.|.......::|:|.||||||..:|...:|.|
Human   479 WWNDLWLNEGFATFMEYFSLEKIFKELSSYE-DFLDARFKTMKKDSLNSSHPISSSVQSSEQIEE 542

  Fly   422 SFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQKFSYKNAEQDNLWESLTQAAHKYRSLPKSY 486
            .||.:||.|||::|.|:..:|.|:.|:..:..||...||.:.:.|:||:|..:..:      ::.
Human   543 MFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTN------QTL 601

  Fly   487 DIKSIMDSWTLQTGYPVINVTRDYAARTAKLNQERYLLN--TQVARAYRGGCWWVPLSYTTQAVQ 549
            |:|.:|.:||||.|:|::.|.:  ..:...:.|||:.||  .::..:.....|.:||||.|:. :
Human   602 DVKRMMKTWTLQKGFPLVTVQK--KGKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSYVTEG-R 663

  Fly   550 DFNNTAPKAWMECGKNGESLPKTIQDLPGPDQWVIFNTQLSTLYKVNYDAQNWKLLIETLTNGDF 614
            :::.....:.:: .|:|      :.:|.....||..|..::..|.|:|...:|:.||..|....:
Human   664 NYSKYQSVSLLD-KKSG------VINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPY 721

  Fly   615 ERIHVI---NRAQLIDDALYLAWTGEQDYEIAMRLIEYLQREREYLPWKSAFENLKRVGRIVRQT 676
                |:   :||.||::...||..|:...:.|..||.||..|....|...|......:..::.:.
Human   722 ----VLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLEKL 782

  Fly   677 PDFEFFKRYMKKLILPIYEHLNGINDTFSAIPQQDQVLLKTMVVNWACQYQVGDCVPQALAYYRN 741
            ...:...|.:.::...:...:.....|....|...:  |::.::.:||.:.:|:|...|:..:.:
Human   783 GYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRE--LRSALLEFACTHNLGNCSTTAMKLFDD 845

  Fly   742 WRAEANPDEKNPVPINVRSTVYCTSIKHGSDSDWEFLWTRYKKSNVAAEKRTILTALGCSREV-- 804
            |.|.   :....:|.:|.:||:....|  :|..|.||..:|......|||..||.||..|.:|  
Human   846 WMAS---NGTQSLPTDVMTTVFKVGAK--TDKGWSFLLGKYISIGSEAEKNKILEALASSEDVRK 905

  Fly   805 --WLLQRYLELTFDPKEAIRKQDSMWAFQAVAFNEVGFLLAKKYFMDNVD-FIYKFYHPL-TKDM 865
              ||::..|.     .:..|.|...:..:.|..:..|.|||..:..:|.: .:.||  || :..:
Human   906 LYWLMKSSLN-----GDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKF--PLGSYTI 963

  Fly   866 SRLLSPLSEQVITLSDFNEFKDFVNNSRQSLKGLEQAIQQTLEIMLTNVQWKERNYHQMS 925
            ..:::..:....|.:..:|.:.|..|..::...| :.:|:.||::..|:||.|:|...::
Human   964 QNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRL-RCVQEALEVIQLNIQWMEKNLKSLT 1022

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SP1029NP_001263065.1 Peptidase_M1 33..431 CDD:279741 172/398 (43%)
M1_APN_2 43..502 CDD:189008 191/459 (42%)
ERAP1_C 583..908 CDD:288671 76/333 (23%)
LNPEPNP_005566.2 Dileucine internalization motif. /evidence=ECO:0000255 53..54
Dileucine internalization motif. /evidence=ECO:0000255 76..77
Tankyrase binding 96..101
M1_APN_2 175..617 CDD:189008 191/461 (41%)
Substrate binding. /evidence=ECO:0000250 428..432 3/3 (100%)
ERAP1_C 689..1009 CDD:314669 79/338 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155396
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0308
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D110058at2759
OrthoFinder 1 1.000 - - FOG0000044
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100307
Panther 1 1.100 - - O PTHR11533
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X67
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.750

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