Protein Alignment SP1029 and LNPEP

DIOPT Version :10

• Sequence 1: NP_652618.1
• Gene: SP1029 / 53473
• FlyBaseID: FBgn0263236
• Length: 932
• Species: Drosophila melanogaster
• Sequence 2: XP_054208557.1
• Gene: LNPEP / 4012
• HGNCID: 6656
• Length: 1097
• Species: Homo sapiens
• Alignment Length: 905
• Identity: 296/905 - (32%)
• Similarity: 480/905 - (53%)
• Gaps: 61/905 - (6%)

  Fly    33 RLPTSLRPQKYHLRILTLLENPEDLRFSGSVKILIEALENTKNVTLHSKNLTIDESQITLRQIGG 97
            ||||::.|.:|.   |:|..|...:.|.|||.|.::||:.|.|:.|||....|  |::|......
Human   239 RLPTAVVPLRYE---LSLHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNI--SRVTFMSAVS 298

  Fly    98 EGKKENCVSSTAVNPSHDFYILNTCQELLAGNTYELYMPFAADLNRQLEGYYRSSYKDPVANLTK 162
            ..:|:..:...|.   |....:...:.||||:.|.|.:.::|:::....|:|..||.|. :|..|
Human   299 SQEKQAEILEYAY---HGQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDE-SNEKK 359

  Fly   163 WISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAISNMPEKETKPHETLAD-YIWCEFQ 226
            :.:.|||||.:||.||||||||.|||.|::.:...::|||:||||:|.:   ..|.| .:..||.
Human   360 YFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSS---VVLDDGLVQDEFS 421

  Fly   227 ESVPMSTYLVAYSVNDFSHKPSTLPNSALFRTWARPNAIDQCDYAAQFGPKVLQYYEQFFGIKFP 291
            |||.|||||||:.|.:..:....: |..|...:|.|..|.|..||.:...|:|::::.:|.|::|
Human   422 ESVKMSTYLVAFIVGEMKNLSQDV-NGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYP 485

  Fly   292 LPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAHSSLADKQRVASVVAHELAHQWFGNLVTMK 356
            |.|:|.:|:|||.|||||||||:|:||..|||.:..||:||::.|..::||||||||||||||||
Human   486 LKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMK 550

  Fly   357 WWTDLWLNEGFATYVASLGVENINPEWRSMEQESLSNLLTIFRRDALESSHPISRPIQMVSEISE 421
            ||.||||||||||::....:|.|..|..|.| :.|.......::|:|.||||||..:|...:|.|
Human   551 WWNDLWLNEGFATFMEYFSLEKIFKELSSYE-DFLDARFKTMKKDSLNSSHPISSSVQSSEQIEE 614

  Fly   422 SFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQKFSYKNAEQDNLWESLTQAAHKYRSLPKSY 486
            .||.:||.|||::|.|:..:|.|:.|:..:..||...||.:.:.|:||:|..:..:      ::.
Human   615 MFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTN------QTL 673

  Fly   487 DIKSIMDSWTLQTGYPVINVTRDYAARTAKLNQERYLLN--TQVARAYRGGCWWVPLSYTTQAVQ 549
            |:|.:|.:||||.|:|::.|.:  ..:...:.|||:.||  .::..:.....|.:||||.|:. :
Human   674 DVKRMMKTWTLQKGFPLVTVQK--KGKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSYVTEG-R 735

  Fly   550 DFNNTAPKAWMECGKNGESLPKTIQDLPGPDQWVIFNTQLSTLYKVNYDAQNWKLLIETLTNGDF 614
            :::.....:.:: .|:|      :.:|.....||..|..::..|.|:|...:|:.||..|....:
Human   736 NYSKYQSVSLLD-KKSG------VINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPY 793

  Fly   615 ERIHVI---NRAQLIDDALYLAWTGEQDYEIAMRLIEYLQREREYLPWKSAFENLKRVGRIVRQT 676
                |:   :||.||::...||..|:...:.|..||.||..|....|...|......:..::.:.
Human   794 ----VLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLEKL 854

  Fly   677 PDFEFFKRYMKKLILPIYEHLNGINDTFSAIPQQDQVLLKTMVVNWACQYQVGDCVPQALAYYRN 741
            ...:...|.:.::...:...:.....|....|...:  |::.::.:||.:.:|:|...|:..:.:
Human   855 GYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRE--LRSALLEFACTHNLGNCSTTAMKLFDD 917

  Fly   742 WRAEANPDEKNPVPINVRSTVYCTSIKHGSDSDWEFLWTRYKKSNVAAEKRTILTALGCSREV-- 804
            |.|.   :....:|.:|.:||:....|  :|..|.||..:|......|||..||.||..|.:|
Human   918 WMAS---NGTQSLPTDVMTTVFKVGAK--TDKGWSFLLGKYISIGSEAEKNKILEALASSEDVRK 977

  Fly   805 --WLLQRYLELTFDPKEAIRKQDSMWAFQAVAFNEVGFLLAKKYFMDNVD-FIYKFYHPL-TKDM 865
              ||::..|.     .:..|.|...:..:.|..:..|.|||..:..:|.: .:.||  || :..:
Human   978 LYWLMKSSLN-----GDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKF--PLGSYTV 1035

  Fly   866 SRLLSPLSEQVITLSDFNEFKDFVNNSRQSLKGLEQAIQQTLEIMLTNVQWKERNYHQMS 925
            ..:::..:....|.:..:|.:.|..|..::...| :.:|:.||::..|:||.|:|...::
Human  1036 QNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRL-RCVQEALEVIQLNIQWMEKNLKSLT 1094

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_652618.1	M1_APN-Q_like	42..497	CDD:341064	187/455 (41%)
		ERAP1_C	582..910	CDD:463368	79/336 (24%)
LNPEP	XP_054208557.1	M1_APN-Q_like	247..684	CDD:341064	187/456 (41%)
		ERAP1_C	761..1081	CDD:463368	79/338 (23%)