DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and erap1b

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_956500.2	Gene:	erap1b / 393175	ZFINID:	ZDB-GENE-040426-934	Length:	963	Species:	Danio rerio

Alignment Length:	968	Identity:	309/968 - (31%)
Similarity:	475/968 - (49%)	Gaps:	142/968 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 YNYYRLPTSLRPQKYHLRI---LTLLENPEDLRFSGSVKILIEALENTKNVTLHSKNLTIDESQI 90
            :|..|||.::.|..|:|.|   ||.|:      |:|||:|.||.|::||.:.||||||.|..:::
Zfish    42 WNKMRLPDTISPLHYNLLIHPNLTSLD------FTGSVQIQIEVLQDTKTIILHSKNLQISSARL 100

  Fly    91 TLRQIGGEG----------KKENCVSSTAVNPSHDFYILNTCQELLAGNTYELYMPFAADLNRQL 145
            ....|..:.          ::...||..|:              |..|:.|.:.:.|||:|:...
Zfish   101 LDANIAQQQPLKVLEYPYFQQIALVSDKAL--------------LKRGHVYSVELHFAANLSESF 151

  Fly   146 EGYYRSSYKDPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAISNMPEKE 210
            .|:|:|:|:....:: :.::.||||..|||.||||||||.|||.|.|.:....|:.|:||||:..
Zfish   152 HGFYKSTYRTSKGDV-RVVASTQFEATSARAAFPCFDEPAFKANFSVQIRREAKHIALSNMPKLR 215

  Fly   211 TKPHETLADYIWCEFQESVPMSTYLVAYSVNDFSHKPSTLPNSALFRTWARPNAIDQCDYAAQFG 275
            |.  |........:|..||.||||||||.|:||.....|..:......:|.|..|||.::|....
Zfish   216 TL--ELKNGLFEDQFDVSVKMSTYLVAYIVSDFLSISKTSQHGVQISVYAVPEKIDQAEFALDAA 278

  Fly   276 PKVLQYYEQFFGIKFPLPK--------------------IDQIAVPDFSAGAMENWGLVTYREIA 320
            .|:|.:|:.:|.|.:||||                    :|..|:|||.:||||||||.||||.|
Zfish   279 VKLLDFYDDYFDIPYPLPKQEKPTIKHAKEEFSVYIICFVDLAAIPDFQSGAMENWGLTTYRESA 343

  Fly   321 LLYSAAHSSLADKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWRS 385
            ||:....||.:||..:..::|||||||||||||||:||.|||||||||.::..:.|...|||.:
Zfish   344 LLFDPHKSSASDKLGITMIIAHELAHQWFGNLVTMQWWNDLWLNEGFAKFMEFVSVNITNPELQ- 407

  Fly   386 MEQESLSNLLTIFRRDALESSHPISRPIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSG 450
            :|...|.........|:|.||||:|.|::..::|.|.||.:||.||:.:|.|:..||..:.|:.|
Zfish   408 VEDYFLGKCFEAMEVDSLSSSHPVSTPVENPAQIQEMFDDVSYDKGACILNMLREFLTPKIFKLG 472

  Fly   451 LQAYLQKFSYKNAEQDNLWESLTQ-------------------------AAHKYRSLPKSYDIKS 490
            :..||:.:||:|....|||||||.                         .|.|:.| ....|:|:
Zfish   473 IVKYLKHYSYQNTVNSNLWESLTNVCDSDGLDEGRLKGDESCRHSASNTGASKWHS-EDELDVKA 536

  Fly   491 IMDSWTLQTGYPVINVTRDYAARTAKLNQERYLLNTQVARAYRGGCWWVPLSYTTQ---AVQDFN 552
            :|::||||.|:|:|.:.  ...|..:|:|||||.:..:::. ....|.|||:|.|.   .|..|
Zfish   537 MMETWTLQEGFPLITIA--VKGREVRLSQERYLKSDDLSQT-SSFLWQVPLTYITSDSTTVHRF- 597

  Fly   553 NTAPKAWMECGKNGESLPKTIQD---LPGPDQWVIFNTQLSTLYKVNYDAQNWKLLIETLTNGDF 614
                            |.||..|   ||....|:.||..:|..|.|:|:...|..|| ||...:.
Zfish   598 ----------------LLKTKTDVLYLPEEVDWIKFNVDMSGYYIVHYEGSGWDDLI-TLLKHNH 645

  Fly   615 ERIHVINRAQLIDDALYLAWTGEQDYEIAMRLIEYLQREREYLPWKSAFENLKRVGRIVRQTPDF 679
            ..:...:||.||::|..|...|:...:.|:.|..||.:|.|.:|....|..|..:.:::.:. |.
Zfish   646 TALSSNDRASLINNAFQLVSVGKLPLDKALDLTLYLSKETEIMPVTQGFNELVPLYKLMEKR-DM 709

  Fly   680 EFFKRYMKKLILPIYEHLNGINDTFSAIPQQ--------DQVLLKTMVVNWACQYQVGDCVPQAL 736
            ...:..||..||.:::.|         |.||        .:.:|::.::.:.|......||..|.
Zfish   710 VELENQMKGYILQLFQKL---------IEQQLWTDEGSVSERMLRSYLLLFGCVRGHPPCVSNAT 765

  Fly   737 AYYRNWRAEANPDEKNPVPINVRSTVYCTSIKHGSDSDWEFLWTRYKKSNVAAEKRTILTALGCS 801
            ..:..||   :.|....:|.:|...|:  |:...::..|:||:.:||:|...:.|..|..||..|
Zfish   766 QLFNLWR---DSDGNMSLPNDVTMAVF--SVGARTEDGWDFLFEKYKESMYVSMKSRIKQALMTS 825

  Fly   802 ----REVWLLQRYLELTFDPKEAIRKQDSMWAFQAVAFNEVGFLLAKKYFMDNVDFIYKFYHPLT 862
                :..|::::.||     .|.|:.||..:...:|:.|...:..|..:...|.|.:.|.:...:
Zfish   826 PLDHKLKWMMEQSLE-----GELIKTQDLPYVVTSVSRNPKAYKHAWDFLQANWDSLIKKFDLGS 885

  Fly   863 KDMSRLLSPLSEQVITLSDFNEFKDFVNNSRQSLKGLEQAIQQTLEIMLTNVQWKERN 920
            ..::.::..::.|..|.....|.::|.:..:.......:.|||.:|.:..|::|.::|
Zfish   886 HSIAHMVVGVTNQYSTREMLAEVRNFFSLLQPETGAELRCIQQAVENIEENIRWMDKN 943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	170/430 (40%)
		M1_APN_2	43..502	CDD:189008	197/516 (38%)
		ERAP1_C	583..908	CDD:288671	79/336 (24%)
erap1b	NP_956500.2	Peptidase_M1	46..453	CDD:279741	170/430 (40%)
		M1_APN_2	54..548	CDD:189008	197/518 (38%)
		ERAP1_C	615..932	CDD:288671	79/337 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590530
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.750