DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and CG3502

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_611781.3	Gene:	CG3502 / 37695	FlyBaseID:	FBgn0046253	Length:	912	Species:	Drosophila melanogaster

Alignment Length:	902	Identity:	332/902 - (36%)
Similarity:	507/902 - (56%)	Gaps:	30/902 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SIETTYNYYRLPTSLRPQKYHLRILTLLENPEDLRFSGSVKILIEALENTKNVTLHSKNLTIDES 88
            ||...|..||||.|:.|..|:|||||.| |..|.||.|||.|.:.|.|.|||:|||:..|.|||:
  Fly    20 SIRAVYEDYRLPRSVEPLHYNLRILTHL-NSTDQRFEGSVTIDLLARETTKNITLHAAYLKIDEN 83

  Fly    89 QITLRQIGGEGKKENCVSSTAVNPSHDFYILNTCQELLAGNTYELYMPFAADLNRQLEGYYRSSY 153
            :.::    ..|:::..|:...||..|:||||:..:||:....|:|.|.|.|.||....|||:|:|
  Fly    84 RTSV----VSGQEKFGVNRIEVNEVHNFYILHLGRELVKDQIYKLEMHFKAGLNDSQSGYYKSNY 144

  Fly   154 KDPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAISNMPEKETKPHETLA 218
            .|.|......::||||.|..||.||||||||.:||.|.:||||||||..:|.||....:.|::|.
  Fly   145 TDIVTKEVHHLAVTQFSPTFARQAFPCFDEPSWKATFNITLGYHKKYMGLSGMPVLRCQDHDSLT 209

  Fly   219 DYIWCEFQESVPMSTYLVAYSVNDFSH---KPSTLPNSALFRTWARPNAIDQCDYAAQFGPKVLQ 280
            :|:||:....:..||||||::|:|..:   :.|...|..:||.|.:|..:.|...:.:..||:|.
  Fly   210 NYVWCDHDTLLRTSTYLVAFAVHDLENAATEESKTSNRVIFRNWMQPKLLGQEMISMEIAPKLLS 274

  Fly   281 YYEQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAHSSLADKQRVASVVAHELA 345
            :||..|.|.|||.|:||:.||.....||||||||||.|..|..:........|...|..||||.|
  Fly   275 FYENLFQINFPLAKVDQLTVPTHRFTAMENWGLVTYNEERLPQNQGDYPQKQKDSTAFTVAHEYA 339

  Fly   346 HQWFGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWRSMEQESLSNLLTIFRRDALESSHPIS 410
            ||||||||||.||.||||.||.:||...|.::::.||||..|:....:|...|.:|:..:...||
  Fly   340 HQWFGNLVTMNWWNDLWLKEGPSTYFGYLALDSLQPEWRRGERFISRDLANFFSKDSNATVPAIS 404

  Fly   411 RPIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQKFSYKNAEQDNLWESLTQA 475
            :.::..:|:...|.:..|:|||..:||:|..:|||:|..|::::|::||:.|..|.:||.||..|
  Fly   405 KDVKNPAEVLGQFTEYVYEKGSLTIRMLHKLVGEEAFFHGIRSFLERFSFGNVAQADLWNSLQMA 469

  Fly   476 AHKYRSLPKSYDIKSIMDSWTLQTGYPVINVTRDYAARTAKLNQERYLLNTQVARAYRGGCWWVP 540
            |.|.:.:...:::...|||||||.|||::.:.|:|......|||.|:.....:.:|  ..|||||
  Fly   470 ALKNQVISSDFNLSRAMDSWTLQGGYPLVTLIRNYKTGEVTLNQSRFFQEHGIEKA--SSCWWVP 532

  Fly   541 LSYTTQAVQDFNNTAPKAWMECGKNGESLPKTIQDLPGPDQWVIFNTQLSTLYKVNYDAQNWKLL 605
            |.:..|.:.|||.|.|:.|:||..|.:.|  .:.|....|:|||.|.|::|:::||||..||:|:
  Fly   533 LRFVRQNLPDFNQTTPQFWLECPLNTKVL--KLPDHLSTDEWVILNPQVATIFRVNYDEHNWRLI 595

  Fly   606 IETLTNG-DFERIHVINRAQLIDDALYLAWTGEQDYEIAMRLIEYLQREREYLPWKSAFENLKRV 669
            ||:|.|. :...||.:|:|||:||.:.||......|:.|..|:|||::|:::|||:.|...|.|:
  Fly   596 IESLRNDPNSGGIHKLNKAQLLDDLMALAAVRLHKYDKAFDLLEYLKKEQDFLPWQRAIGILNRL 660

  Fly   670 GRIVRQTPDFEFFKRYMKKLILPIYEH---LNGINDTFSAIPQQDQVLLKTMVVNWACQYQVGDC 731
            |.:: ...:...||.||:||:||:|..   |:||.:   |.|....:.......:.||:|.|.||
  Fly   661 GALL-NVAEANKFKNYMQKLLLPLYNRFPKLSGIRE---AKPAIKDIPFAHFAYSQACRYHVADC 721

  Fly   732 VPQALAYYRNWRAEANPDEKNPVPINVRSTVYCTSIKHGSDSDWEFLWTRYKKSNVAAEKRTILT 796
            ..||.......|.|...:    :|.:.:...||:.:..|.|:::..::..::.|...:::|.:.:
  Fly   722 TDQAKILAITHRTEGQLE----LPSDFQKVAYCSLLDEGGDAEFLEVFGLFQNSTNGSQRRILAS 782

  Fly   797 ALGCSREVWLLQRYLELTFDPKEAIRKQDSMWAFQAVAFNEVGFLLAKKYFMDNVDFIYKFYHPL 861
            ||||.|.....:::|..|.:..|.:.....|.|.::....|........|.:.:...:.:.:.
  Fly   783 ALGCVRNFGNFEQFLNYTLESDEKLLGDCYMLAVKSALNREPLVSPTANYIISHAKKLGEKFK-- 845

  Fly   862 TKDMSRLLSPLSEQVITLSDFNEFKDFVNNSRQSLKGLEQAIQQTLEIMLTNVQWKE 918
            .|:::.||..|::.:.:..:.:..|    ...:.||..|:.:::.|.....|.:|::
  Fly   846 KKELTGLLLSLAQNLRSTEEIDRLK----AQLEDLKEFEEPLKKALYQGKMNQKWQK 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	174/400 (44%)
		M1_APN_2	43..502	CDD:189008	200/461 (43%)
		ERAP1_C	583..908	CDD:288671	91/328 (28%)
CG3502	NP_611781.3	Peptidase_M1	29..425	CDD:279741	174/400 (44%)
		M1_APN_2	37..496	CDD:189008	200/463 (43%)
		ERAP1_C	573..890	CDD:288671	92/330 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449977
Domainoid	1	1.000	114	1.000	Domainoid score	I6014
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10752at50557
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		otm40365
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	9	8.850