DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and Trhde

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_001102461.1	Gene:	Trhde / 366894	RGDID:	728895	Length:	1066	Species:	Rattus norvegicus

Alignment Length:	915	Identity:	292/915 - (31%)
Similarity:	471/915 - (51%)	Gaps:	77/915 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 RLPTSLRPQKYHLRILTLLENPEDLRFSGSVKILIEALENTKNVTLHSKNLTIDESQITLRQIGG 97
            ||...|:|..|:|.:...:||   ..|||.|.:.|.....|:.|.||:..:.:::.|:...:..|
  Rat   182 RLSGHLKPLHYNLMLTAFMEN---FTFSGEVNVEIACQNATRYVVLHASRVAVEKVQVAEDRAFG 243

  Fly    98 EGKKENCVSSTAVNPSHDFYILNTCQELL--------AGNTYELYMPFAADLNRQLEGYYRSSYK 154
                       || |...|::....|.|:        |...|.|.:.:.|.:..:|.|::||||
  Rat   244 -----------AV-PVAGFFLYPQTQVLVVVLNRTLDAQRHYNLKIIYNALIENELLGFFRSSY- 295

  Fly   155 DPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAISNMPEKETKPHETLAD 219
             .:....:::.||||.|..||.||||||||.:||.|.:::.:...|.::|||| .||...|. ..
  Rat   296 -VIHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMP-VETSVFEE-DG 357

  Fly   220 YIWCEFQESVPMSTYLVAYSVNDFSHKPSTLPNSALFRTWARPNAI--DQCDYAAQFGPKVLQYY 282
            ::...|.::..||||.:|:::.:|:::.:|..:..:.|.:|||:||  ...|||.....:::::|
  Rat   358 WVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRLIEFY 422

  Fly   283 EQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAHSSLADKQRVASVVAHELAHQ 347
            |.:|.:.:.|||:|.:|||.....|||||||..:.|..:|...:.||::....|..|:.||:.||
  Rat   423 EDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQ 487

  Fly   348 WFGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWRSMEQESLSNLL-TIFRRDALESSHPISR 411
            |||:|||..||.|:||.||||.|...:|.:.:.|.|...:|..|:::| .:...|.|.||||:|:
  Rat   488 WFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPSWNMEKQRFLTDVLHEVMLLDGLASSHPVSQ 552

  Fly   412 PIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQKFSYKNAEQDNLWESLTQAA 476
            .:...::|.:.||.|:|:||:.::||:..|:|...|:.|||.||....|.||.:::||.:|::|.
  Rat   553 EVLRATDIDKVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEAL 617

  Fly   477 HKYRSLPKSYDIKSIMDSWTLQTGYPVINVTRDYAARTAKLNQERYLLNTQVARAYRGGC----- 536
            .:.   .|..:|:.:||.||||.|||||.:..:..|       |..:|.||....|..|.
  Rat   618 KRN---GKYVNIQEVMDQWTLQMGYPVITILGNMTA-------ENRILITQQHFIYDIGAKTKAL 672

  Fly   537 --------WWVPLSYTTQAVQDFNNTAPKAWMECGKNGESLPKTIQDLPGPDQWVIFNTQLSTLY 593
                    |.:||   |..|.:.::.:.:|.:......|....|..|   ...|::.|...:..:
  Rat   673 QLQNSSYLWQIPL---TIVVGNRSHVSSEAIIWVSNKSEHHRITYLD---KGSWILGNINQTGYF 731

  Fly   594 KVNYDAQNWKLLIETLTNGDFERIHVINRAQLIDDALYLAWTGEQDYEIAMRLIEYLQREREYLP 658
            :||||.:||:|||:.|.. :.|.:.|.|||.|||||..||..|.....|.:.:|.||..|:::||
  Rat   732 RVNYDLRNWRLLIDQLIR-NHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLP 795

  Fly   659 WKSAFENLKRVGRIVRQTPDFEFFKRYMKKLILPIYEHLNGINDTFS-----AIPQQDQVLLKTM 718
            |.:|...|..:.:::.:..::..|..|:.|.:...|..|....:.|:     |..|.::  |:..
  Rat   796 WHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYSKLGWPKNNFNGSVVQASYQHEE--LRRE 858

  Fly   719 VVNWACQYQVGDCVPQALAYYRNWRAEANPDEKNPVPINVRSTVYCTSIKHGSDSDWEFLWTRYK 783
            |:..||.:....|..||.....:|.:    ..:|.:|:|||..||||.:....:..|||:|.::.
  Rat   859 VIMLACSFGNKHCHQQASTLISDWIS----SNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFH 919

  Fly   784 KSNVAAEKRTILTALGCSREVWLLQRYLELTFDPKEAIRKQDSMWAFQAVAFNEVGFLLAKKYFM 848
            .:...:||:.:|.||.||.:..||.|.|.|:.: .|.:..||::.....||.|..|..||.|:|.
  Rat   920 STTAVSEKKILLEALTCSDDRNLLSRLLNLSLN-SEVVLDQDAIDVIIHVARNPHGRDLAWKFFR 983

  Fly   849 DNVDFIYKFYHPLTKDMSRLLSPLSEQVITLSDFNEFKDFVNNSRQSLKGLEQA-IQQTLEIMLT 912
            |....:...|.......|:|:|.::|.:.|..:..|.|:|:    :|..|:..| ..:.:|.:..
  Rat   984 DKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFM----KSYDGVASASFSRAVETVEA 1044

  Fly   913 NVQWK 917
            ||:||
  Rat  1045 NVRWK 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	139/408 (34%)
		M1_APN_2	43..502	CDD:189008	163/469 (35%)
		ERAP1_C	583..908	CDD:288671	99/330 (30%)
Trhde	NP_001102461.1	M1_APN-Q_like	190..635	CDD:341064	159/466 (34%)
Trhde	NP_001102461.1	ERAP1_C	720..1044	CDD:403137	101/335 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349246
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850