DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and CG10602

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_609916.5	Gene:	CG10602 / 35146	FlyBaseID:	FBgn0032721	Length:	684	Species:	Drosophila melanogaster

Alignment Length:	573	Identity:	142/573 - (24%)
Similarity:	225/573 - (39%)	Gaps:	160/573 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 SVKILIEALENTKNVTLHSKNLTIDESQITLRQ----IGGEGKKENCVSSTAVNPSHDFYILNTC 122
            :.||....|...|.:|.:...:.:|...|.:..    .||        |...:|    |:|.:..
  Fly   104 ATKIQGSVLHRFKVLTANLDKILLDVRDINVTNATLLAGG--------SELPIN----FFISDAV 156

  Fly   123 QELLAGNTYELYMPFA---ADLNRQLEGYYRSSYKDPVANLTKWISVT------------QFEPA 172
            .::  |....|.:|..   ..||.::: |..||    .|:..:|::.|            |.:..
  Fly   157 DDI--GQKLTLELPSGTAKGSLNVRID-YETSS----SASGLQWLNPTQTLGKEHPYMFSQCQAI 214

  Fly   173 SARLAFPCFDEPDFKAPFVVTLGYHKKYTAISNMPEKETKPHETLADYIWCEFQESVPMSTYLVA 237
            .||...||.|.|..|..:..|:.:..:.||:.:....:.:|.:||       |::.||:..||||
  Fly   215 HARSVIPCQDTPAVKFTYDATVEHPSELTALMSALIDKKEPGKTL-------FKQEVPIPAYLVA 272

  Fly   238 YSVNDFSHKPSTLPNSALFRTWARPNAIDQCDYAAQF--------------GPKVLQYYEQFFGI 288
            .::.....:|.. .||::   ||....:|.|  |.:|              ||.|.:.|:..
  Fly   273 IAIGKLVSRPLG-ENSSV---WAEEAIVDAC--AEEFSETATMLKTATELCGPYVWKQYDLL--- 328

  Fly   289 KFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAHSSLADKQRVASVVAHELAHQWFGNLV 353
                     :..|.|..|.||| ..:|:....||  |...||||      |||||:||.|.||||
  Fly   329 ---------VMPPSFPFGGMEN-PCLTFVTPTLL--AGDKSLAD------VVAHEIAHSWTGNLV 375

  Fly   354 TMKWWTDLWLNEGFATYVASLGVENINPEWRSMEQESLSNLLTIFR--RDALESSHPISRPIQMV 416
            |.|.:...||||||..:|.|..|..:... :.::.:.||||..:..  |..|..:..:::   :|
  Fly   376 TNKNFEHFWLNEGFTVFVESKIVGRMQGA-KELDFKMLSNLTDLQECIRTQLNKTPELTK---LV 436

  Fly   417 SEIS-----ESFDQISYQKGSTVLRMMH-LFLGEESFRSGLQAYLQKFSYKNAEQD--------- 466
            .::|     ::|..:.|.||||.||.:. ||.|...|...|:.||:|::||:.|..
  Fly   437 VDLSNCGPDDAFSSVPYIKGSTFLRYLEDLFGGPTVFEPFLRDYLKKYAYKSIETKDFQSALYDY 501

  Fly   467 ---------------NLW--------------ESLTQAAHKYRSLPKSYDIKSIMDSWTLQTGYP 502
                           :||              |||.....:..||..|..:..:.||..::|...
  Fly   502 FIDTDKKDKLSAVDWDLWLKSEGMPPVIPNFDESLANVTKELASLWSSKSVAELADSAEIKTTIS 566

  Fly   503 V-----------------------INVTRD-YAARTAKLNQERYLLNTQVARA 531
            :                       ||:... |..:::|..:.|:.||..:.||
  Fly   567 IHQLIDFLGKLIESKDIVDLNEGKINLLESTYNLKSSKNAEVRFRLNRLIIRA 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	105/408 (26%)
		M1_APN_2	43..502	CDD:189008	133/518 (26%)
		ERAP1_C	583..908	CDD:288671
CG10602	NP_609916.5	Ribosomal_L13	16..>50	CDD:294238
		leuko_A4_hydro	79..681	CDD:274120	142/573 (25%)
		M1_LTA4H	79..520	CDD:189006	123/472 (26%)
		Leuk-A4-hydro_C	541..680	CDD:286244	15/79 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462057
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840