DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and lnpep

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	XP_021331684.1	Gene:	lnpep / 322814	ZFINID:	ZDB-GENE-030131-1534	Length:	1026	Species:	Danio rerio

Alignment Length:	946	Identity:	299/946 - (31%)
Similarity:	483/946 - (51%)	Gaps:	108/946 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GLATADSSADS---IETTYNYY-----RLPTSLRPQKYHLRILTLLENPE--DLRFSGSVKILIE 68
            |...::||..|   |.|:...:     |||.|:.|..|::.:     :|:  .:.|.|:|.|::.
Zfish   150 GCQKSNSSMSSIYPISTSGELFPWTDLRLPVSVHPVHYNISL-----HPDLNSMTFQGNVSIVVL 209

  Fly    69 ALENTKNVTLHSKNLTIDESQITLRQIGGEGKKENCVSSTAVNPSHDFYILNTCQEL-------L 126
            .:..|||:.|||.::                   |.:..|..:..:.|......|::       |
Zfish   210 VMHETKNIILHSSDM-------------------NIIKVTFDDKEYRFLEYKPWQQIAIKFPEDL 255

  Fly   127 AGNTYELYMPFAADLNRQLEGYYRSSYKDPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFV 191
            ....|.|...:.|:|:...:|:|.|||.| .|...:.::.|||||.:||.||||||||.||:.||
Zfish   256 KKGQYVLKFSYKANLSNSYDGFYNSSYVD-TAGTKRVLAATQFEPLAARKAFPCFDEPAFKSTFV 319

  Fly   192 VTLGYHKKYTAISNMPE-KETKPHET-LADYIWCEFQESVPMSTYLVAYSVNDFSHKPSTLPNSA 254
            |.:....||.::||||: |.|..:|. |.:   .||:.||.|||||||:.|.:||.....:..:.
Zfish   320 VKMTREAKYISLSNMPKIKTTDLNENGLQE---DEFESSVKMSTYLVAFIVAEFSSHSKNVSKTT 381

  Fly   255 LFRTWARPNAIDQCDYAAQFGPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREI 319
            : ..:|.|:..||..||.:...|:|::|..||.|::||.|:|.:|:|||.|||||||||:|:||.
Zfish   382 V-SVYAVPDKKDQVHYALETACKLLKFYNTFFEIEYPLSKLDLVAIPDFLAGAMENWGLITFRET 445

  Fly   320 ALLYSAAHSSLADKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWR 384
            .||. ...||..|||.|.||:|||||||||||||||:||.|||||||||||:..:.:||:.|: .
Zfish   446 TLLV-GNQSSRFDKQLVTSVIAHELAHQWFGNLVTMRWWNDLWLNEGFATYMQYMSIENVFPD-L 508

  Fly   385 SMEQESLSNLLTIFRRDALESSHPISRPIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRS 449
            .::.|.|:.......:|||.||||:|..:....::.|.||.:||:||:::|.|::..|.:..|..
Zfish   509 DIDIEFLNVRFKALAKDALNSSHPVSTFVSTPEQVEEMFDSVSYEKGASILLMLNATLRDGEFHK 573

  Fly   450 GLQAYLQKFSYKNAEQDNLWESLTQAAHKYRSLPKSYDIKSIMDSWTLQTGYPVINVTRDYAART 514
            |:..|||.::..|.|..:||.||:|.:      .:|.::..:|::||:..|:|::.|.|:....|
Zfish   574 GVIEYLQNYNLSNTESKDLWNSLSQVS------KQSLNVSEMMNTWTVHKGFPLVTVKRNGPQVT 632

  Fly   515 AKLNQERYLLNTQVARAYRG----GCWWVPLSYTTQAVQDFNNTAPKAWMECG-----KNGESLP 570
              |:||.:|||     |..|    ..|.:||:|.        |.:......|.     |:.|:
Zfish   633 --LSQEHFLLN-----AENGTDDSSLWHIPLTYV--------NDSCSVLRSCKQVFHLKDKEA-- 680

  Fly   571 KTIQDLPGPDQWVIFNTQLSTLYKVNYDAQNWKLLIETLTNGDFERIHVINRAQLIDDALYLAWT 635
             |:| |||..:|:.||.:....|.|:||.|.|..||..| ..|...:...::|.||::...|:..
Zfish   681 -TLQ-LPGQVKWLKFNFRSDGFYIVHYDEQGWSDLISAL-KVDVNVLPSEDKAALINNIFALSRL 742

  Fly   636 GEQDYEIAMRLIEYLQREREYLPWKSAFENLKRVGRIVRQTPDFEFFKRYMKKLILPIYEHLNGI 700
            |:..:...:.|::|::.|.|..|...|...|.::.|::.:..|...    ...:...|..|...:
Zfish   743 GKVSFRQVLNLMDYIRNETETAPLTEALSQLGQIYRLLDKRSDLNL----ASSMTTYIESHFGSL 803

  Fly   701 --NDTFSAIPQQDQVLLKTMVVNWACQYQVGDCVPQALAYYRNWRAEANPDEKNPVPINVRSTVY 763
              :.::.......::.|::.::..||.....:|..||...:..|.|.   ::...:|.::..||:
Zfish   804 MESQSWEVETSVSKMTLRSALLETACALNRPNCTTQARRLFDQWLAS---NKTLQIPSDLMRTVF 865

  Fly   764 CTSIKHGSDSDWEFLWTRYKKSNVAAEKRTILTALGCSREV----WLLQRYLELTFDPKEAIRKQ 824
            ..:.|  :|..|..|...||.|....|||.:|.||..:::|    |:||:.|    |..| |:.|
Zfish   866 KVAAK--TDEGWSKLLGSYKHSIYDTEKRKMLEALASTQDVRKIIWVLQKSL----DGSE-IQNQ 923

  Fly   825 DSMWAFQAVAFNEVGFLLAKKYFMDNVDFIYKFYHPLTKDMSRLLSPLSEQVITLSDFNEFKDFV 889
            :.......|..:..|:|.|..:..:|.:.|.:.:...:..:..:::..:.|..|.:...|.::|.
Zfish   924 EFPLVIHTVCRDFAGYLYAWDFMKENWEKITQKFPIGSFAIQSIITSTTSQFSTKTHLAEVQNFF 988

  Fly   890 NNSRQSLKGLE-QAIQQTLEIMLTNVQWKERNYHQM 924
              |....||.: :.:|:.:|.:..|::|.|:|.:.:
Zfish   989 --SSLGAKGSQMRIVQEAIETIKHNMRWMEKNLNTL 1022

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	165/408 (40%)
		M1_APN_2	43..502	CDD:189008	182/469 (39%)
		ERAP1_C	583..908	CDD:288671	75/331 (23%)
lnpep	XP_021331684.1	M1_APN_2	185..620	CDD:189008	182/471 (39%)
lnpep	XP_021331684.1	ERAP1_C	690..1009	CDD:314669	77/335 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590552
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850