DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and CG2111

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster

Alignment Length:	915	Identity:	308/915 - (33%)
Similarity:	505/915 - (55%)	Gaps:	34/915 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 RLPTSLRPQKYHLRILTLLENPEDLRFSGSVKILIEALENTKNVTLHSKNLTIDESQ-ITLRQIG 96
            |||..|.|..|.:.|:|.:..|.. .|.|:|.|.:.:..:||.:.|::.:|.|.:.: :||....
  Fly    25 RLPKWLVPLSYRVDIVTRINQPYQ-PFGGTVVIDLRSERSTKRIVLNAHDLAIGKRRAVTLSDKN 88

  Fly    97 GEGKKENCVSSTAVNPSHDFYILNTCQELLAGNTYELYMPFAADLNRQLEGYYRSSYKDPVANLT 161
            |....   |||..::.......::..:.|....||.:.:.|.:.|.....|:|.|:|.|....||
  Fly    89 GNSVP---VSSIQMDIKLSRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHNTTLT 150

  Fly   162 KWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAISNMPEKETKPHETLADYIWCEFQ 226
            :|::.|||||..||.||||||:|.|:.||.:.|.:...|.|:||||.:.|..|.:|.||:|.:|.
  Fly   151 QWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRHASLKDYVWTQFV 215

  Fly   227 ESVPMSTYLVAYSVNDF------SHKPSTLPNSALFRTWARPNAIDQCDYAAQFGPKVLQYYEQF 285
            ||.||.|||||:.::.|      |.:.|..|.|    |||||:|:.|.::|......:|.:||..
  Fly   216 ESHPMQTYLVAFMISKFDRPGFTSSERSDCPIS----TWARPDALSQTEFANMVVAPLLSFYEDL 276

  Fly   286 FGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAHSSLADKQRVASVVAHELAHQWFG 350
            |...:...|||.:|:|||:..:.|||||..:.|.:|||.:..||:.|:|.||..||..:.:||||
  Fly   277 FNSTYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVVNQWFG 341

  Fly   351 NLVTMKWWTDLWLNEGFATYVASLGVENINPEWRSMEQESLSNLLTIFRRDALESSHPISRPIQM 415
            |||::.||.::||...||.|::..||.::.|||...|:.:|...|::...||..::..::..:..
  Fly   342 NLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYDAHVNTDLVTASVPD 406

  Fly   416 VSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQKFSYKNAEQDNLWESLTQAAHKYR 480
            .|.|..::::|..:|.:.:..|:|..:|||::.:.|:.||..::.:.|...:.|:.|.....:..
  Fly   407 ESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDFWDLLQLQVDRNG 471

  Fly   481 SLPKSYDIKSIMDSWTLQTGYPVINVTRDYAARTAKLNQERYLLNTQVARAY-RGGCWWVPLSYT 544
            .|.|..:|..||..|..|.|||::.|||:|..|||.::|:|:.:..|....: |..|||||||||
  Fly   472 RLGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFFITPQFRNRWARNPCWWVPLSYT 536

  Fly   545 TQAVQDFNNTAPKAWMEC------GKNGESLPKTIQDLPGPDQWVIFNTQLSTLYKVNYDAQNWK 603
            ..:.|.....:...|:.|      .|:...|.:.::  ..|..|::||.|.:..::||||.:||:
  Fly   537 CPSCQHSEIISFSRWLTCPTSKPSSKSNTVLLEKLE--AEPTDWILFNVQHTAPFRVNYDLRNWQ 599

  Fly   604 LLIETLTN-GDFERIHVINRAQLIDDALYLAWTGEQDYEIAMRLIEYLQREREYLPWKSAFENLK 667
            ||.:||.: ..|..||.:|||||:||...|||:|:.:|::|:.::.||:.|.|::.|.:...:.:
  Fly   600 LLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGILGYLEHEDEFVVWVATEISFE 664

  Fly   668 RVGRIVRQTPDFEFFKRYMKKLILPIYEHLNGINDTFSAIPQQDQVLLKTMVVNWACQYQVGDCV 732
            |:..:.:..|::..||.||:.|:...::.:...:.|.|:    ..:..:.:::..||:|::..||
  Fly   665 RINNVAKSNPNYLIFKTYMRLLLERQFKRVISSDLTSSS----GNMTHRPVIIRLACEYELPACV 725

  Fly   733 PQALAYYRNWRAEANPDEKNPVPINVRSTVYCTSIKHGSDSDWEFLWTRYKKSNVAAEKRTILTA 797
            ..|    |....:..|::...:.|..|.||.||::|.|::.|.:.:.:.||:||.||||.::|||
  Fly   726 SLA----RREFMKGTPEKGGWMTIRERETVVCTAVKFGTEGDRDMVESMYKRSNFAAEKESLLTA 786

  Fly   798 LGCSREVWLLQRYLELTFDPKEAIRKQDSMWAFQAVAFNEVGFLLAKKYFMDNVDFIYKFYHPLT 862
            |.|||.|:.|||.|..||: ...:|||::...|:||..|.:|:.|||||...|:..|..:....|
  Fly   787 LACSRNVFALQRVLIWTFE-SSGVRKQNARRTFKAVVSNSMGYRLAKKYVSVNMQNIRNYCSNST 850

  Fly   863 KDMSRLLSPLSEQVITLSDFNEFKDFVNNSRQSLKGLEQAIQQTLEIMLTNVQWKERNYHQMSRS 927
            ..:..|::||.|.:.|..:...|..|.....:.:.|.|:.|:..||....|:.|:...:..|.::
  Fly   851 DKVVNLMTPLIECLSTPKELLYFSKFFKEILRDMNGSERLIKILLERGNDNIHWQRTKFRPMLQA 915

  Fly   928 IQQLL 932
            |:.::
  Fly   916 IRDII 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	145/404 (36%)
		M1_APN_2	43..502	CDD:189008	160/465 (34%)
		ERAP1_C	583..908	CDD:288671	108/325 (33%)
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	145/403 (36%)
		M1_APN_2	33..493	CDD:189008	160/467 (34%)
		ERAP1_C	579..897	CDD:288671	109/326 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449982
Domainoid	1	1.000	110	1.000	Domainoid score	I3949
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10752at50557
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		otm40365
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.850