DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and CG31198

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster

Alignment Length:	963	Identity:	297/963 - (30%)
Similarity:	477/963 - (49%)	Gaps:	131/963 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLFVAALGLGLA-TADSSAD-----SIETTYNYYRLPTSLRPQKYHLRILT-LLENPEDLRFSGS 62
            :|.||.:.|..| |...|.|     ::.|..|.|||...:.|..|::.:.. |||...:.||:..
  Fly     8 VLLVACVSLASAGTRQLSVDVQPPATLATELNEYRLAEHITPVNYNITLRPYLLETDGNKRFTFD 72

  Fly    63 VKILIEALEN--TKNVTLHSKNL-----------TIDESQITLRQIGGEGKKENCVSSTAVNPSH 114
            .::.||.:.|  |.::.||||||           |.:.:..|:.||.         ::...|...
  Fly    73 GEVWIEVISNQTTNDIYLHSKNLTYSVREYWQKPTTEVANPTVIQIS---------ATNTTNYDT 128

  Fly   115 DFYILNTCQELLAGNTYELYMPFAADLNRQLEGYYRSSYKDPVANLTKWISVTQFEPASARLAFP 179
            |...|.....|.|..||.|:..:...:...:.|:|||||.|. .|:|||:..|||:...||.|||
  Fly   129 DIVKLTASTALTANTTYILHFVYTGLMEDDMHGFYRSSYVDD-NNVTKWLGSTQFQTHHARRAFP 192

  Fly   180 CFDEPDFKAPFVVTLGYHKKYTAISNMPEKETKPHETLADYIWCEFQESVP-MSTYLVAYSVNDF 243
            .||||.|||.|.|||..|:.:.::||  .:....:.:..:.|:.:..::.| |||||:|:.:::|
  Fly   193 SFDEPQFKATFDVTLKRHRTFNSVSN--TRLISSYPSTEEGIFSDVYKTTPKMSTYLLAFIISEF 255

  Fly   244 -SHKPSTLPNSALFRTWARPNAIDQCDYAAQFGPKVLQYYEQFFG---IKFPLPKIDQIAVPDFS 304
             :.|...      |..:|||....|..|....|.::|:...|:..   ......|:|..|:||||
  Fly   256 VARKDDD------FGVYARPEYYAQTQYPYNVGIQILEEMGQYLDKDYYSMGNDKMDMAAIPDFS 314

  Fly   305 AGAMENWGLVTYREIALLYSAAHSSLADKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFAT 369
            |||||||||:||||.:||...:.::||.:|.:|:|||||.||.|||:|||.|||:..|||||||.
  Fly   315 AGAMENWGLLTYRERSLLVDESATTLASRQSIAAVVAHEQAHMWFGDLVTCKWWSYTWLNEGFAR 379

  Fly   370 YVASLGVENINPEWRSMEQESLSNLLTIFRRDALESSHPIS-RPIQMVSEISESFDQISYQKGST 433
            |....|...:..:|...:|..:..:.::...|:..:::|:| ......:.:|..|:.|||.||:|
  Fly   380 YFQYFGTAMVEDKWELEKQFVVDQVQSVMAMDSTNATNPLSDENTYTPAHLSRMFNSISYNKGAT 444

  Fly   434 VLRMMHLFLGEESFRSGLQAYLQKFSYKNAEQDNL---WESLTQAAHKYRSLP-KSYD--IKSIM 492
            .:||:...:||:.|:..||.||:|:.|:::..:.|   |::         :.| .||:  .|.|.
  Fly   445 FIRMIKHTMGEQQFQKSLQEYLKKYEYQSSLPEYLLGAWQA---------NWPNSSYNESSKDIF 500

  Fly   493 DSWTLQTGYPVINVTRDYAARTAKLNQERYLL----NTQVARAYRGGCWWVPLSYTTQAVQDFNN 553
            .|:|.|.|||:||||  .........|:|:||    .:..:..|.     ||:||||....:|.|
  Fly   501 KSFTEQVGYPLINVT--VGNSQVSFTQKRFLLKESDGSDSSLKYT-----VPISYTTSETNNFLN 558

  Fly   554 TAPKAWMECGKNGESLPKTIQDLPGPDQWVIFNTQLSTLYKVNYDAQNWKLLIETLTNGDFERIH 618
            |.||..::     .::..|:| .....:|::.|.|.:..|:|.|...||..:...|...::..||
  Fly   559 TTPKFILK-----PNVTTTVQ-FNSTIKWIVVNIQQTGYYRVTYSDDNWHAIHHALITANWGGIH 617

  Fly   619 VINRAQLIDDALYLAWTGEQDYEIAMRLIEYLQREREYLPWKSAFENLKRVG-RIVRQTPDFEFF 682
            ..||||::||...||..|...|.:.:.:|||||.|..|:||.|||.....:. |:...|.||.:
  Fly   618 ENNRAQIVDDLFNLARAGYVTYNLTLDVIEYLQTETNYIPWTSAFNGFNYLTIRLGNDTADFNY- 681

  Fly   683 KRYMKKLILPIYEHL---NGINDTFSAIPQQDQVLLKTMVVNWACQYQVGDCVPQALAYYRNWRA 744
              |::.|....|..|   ...|||  |:    .:.|:|.:::|||:|...||:.||..|:::...
  Fly   682 --YIQTLTNKAYNQLGFNEASNDT--AL----DIYLRTKILSWACRYGSSDCISQAQGYFQSLAT 738

  Fly   745 EANPDEKNPVPINVRSTVYCTSIKHGSDSDWEFLWTRYKKSNVAAEKRTILTALGCSREVWLLQR 809
                     ||.|:|:||||..::.|.:::::.|:.::|...||.|:..:..:.||.:...|:::
  Fly   739 ---------VPKNIRATVYCVGLREGGEAEFQALYNKFKNETVATEETLLQNSFGCVKTQSLIEK 794

  Fly   810 YLELTFDPKEAIRKQDSMWAFQAVAFNEVGFLLAKKYFMDNVD------FIYKFYHPLTKDM--- 865
            ..:|..  .:.||:||.            ..:||..|..:|.:      .:.:.|..|.:.|
  Fly   795 VFDLII--SDEIRRQDK------------SSVLATLYTENNENVSPVFALVTQKYEELAEAMGGY 845

  Fly   866 ---SRLLSPLSEQVITLSDFNEFKDF-------VNNSRQSLKGLEQAIQQTLE 908
               :.::|.::.:..|.....:.::|       ..:|:.:|...|..:::.||
  Fly   846 SAVATVISNIAARFTTNQQLTDLENFNKANGAKFGSSQATLTAAEATVKENLE 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	144/417 (35%)
		M1_APN_2	43..502	CDD:189008	166/484 (34%)
		ERAP1_C	583..908	CDD:288671	90/347 (26%)
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	144/417 (35%)
		M1_APN_2	50..510	CDD:189008	166/486 (34%)
		ERAP1_C	582..898	CDD:288671	90/347 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	7	6.920