DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1029 and TRHDE

DIOPT Version :9

Sequence 1:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_037513.2	Gene:	TRHDE / 29953	HGNCID:	30748	Length:	1069	Species:	Homo sapiens

Alignment Length:	920	Identity:	294/920 - (31%)
Similarity:	468/920 - (50%)	Gaps:	87/920 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 RLPTSLRPQKYHLRILTLLENPEDLRFSGSVKILIEALENTKNVTLHSKNLTIDESQITLRQIGG 97
            ||...|:|..|:|.:...:||   ..|||.|.:.|.....|:.|.||:..:.:::.|:...:..|
Human   185 RLSGHLKPLHYNLMLTAFMEN---FTFSGEVNVEIACRNATRYVVLHASRVAVEKVQLAEDRAFG 246

  Fly    98 EGKKENCVSSTAVNPSHDFYILNTCQELL--------AGNTYELYMPFAADLNRQLEGYYRSSYK 154
                       || |...|::....|.|:        |...|.|.:.:.|.:..:|.|::||||
Human   247 -----------AV-PVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNALIENELLGFFRSSY- 298

  Fly   155 DPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAISNMPEKETKPHETLAD 219
             .:....:::.||||.|..||.||||||||.:||.|.:::.:...|.::|||| .||...|. ..
Human   299 -VLHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMP-VETSVFEE-DG 360

  Fly   220 YIWCEFQESVPMSTYLVAYSVNDFSHKPSTLPNSALFRTWARPNAI--DQCDYAAQFGPKVLQYY 282
            ::...|.::..||||.:|:::.:|:::.:|..:..:.|.:|||:||  ...|||.....:::::|
Human   361 WVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRLIEFY 425

  Fly   283 EQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAHSSLADKQRVASVVAHELAHQ 347
            |.:|.:.:.|||:|.:|||.....|||||||..:.|..:|...:.||::....|..|:.||:.||
Human   426 EDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQ 490

  Fly   348 WFGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWRSMEQESLSNLL-TIFRRDALESSHPISR 411
            |||:|||..||.|:||.||||.|...:|.:.:.|.|...:|..|:::| .:...|.|.||||:|:
Human   491 WFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDGLASSHPVSQ 555

  Fly   412 PIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQKFSYKNAEQDNLWESLTQAA 476
            .:...::|...||.|:|:||:.::||:..|:|...|:.|||.||....|.||.:::||.:|::|.
Human   556 EVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEAL 620

  Fly   477 HKYRSLPKSYDIKSIMDSWTLQTGYPVI----NVTR-------------DYAART--AKLNQERY 522
            .:.   .|..:|:.:||.||||.|||||    |.|.             |.:|:|  .||....|
Human   621 KRN---GKYVNIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSY 682

  Fly   523 LLNTQVARAYRGGCWWVPLSYTTQAVQDFNNTAPKAWMECGKNGESLPKTIQDLPGPDQWVIFNT 587
            |             |.:||   |..|.:.::.:.:|.:......|....|..|   ...|::.|.
Human   683 L-------------WQIPL---TIVVGNRSHVSSEAIIWVSNKSEHHRITYLD---KGSWLLGNI 728

  Fly   588 QLSTLYKVNYDAQNWKLLIETLTNGDFERIHVINRAQLIDDALYLAWTGEQDYEIAMRLIEYLQR 652
            ..:..::||||.:||:|||:.|.. :.|.:.|.|||.|||||..||..|.....|.:.:|.||..
Human   729 NQTGYFRVNYDLRNWRLLIDQLIR-NHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSE 792

  Fly   653 EREYLPWKSAFENLKRVGRIVRQTPDFEFFKRYMKKLILPIYEHL----NGINDTFSAIPQQDQV 713
            |:::|||.:|...|..:.:::.:..::..|..|:.|.:...|..|    |..|.:......|.:.
Human   793 EKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPKNNFNGSLVQASYQHEE 857

  Fly   714 LLKTMVVNWACQYQVGDCVPQALAYYRNWRAEANPDEKNPVPINVRSTVYCTSIKHGSDSDWEFL 778
             |:..|:..||.:....|..||.....:|.:    ..:|.:|:|||..||||.:....:..|||:
Human   858 -LRREVIMLACSFGNKHCHQQASTLISDWIS----SNRNRIPLNVRDIVYCTGVSLLDEDVWEFI 917

  Fly   779 WTRYKKSNVAAEKRTILTALGCSREVWLLQRYLELTFDPKEAIRKQDSMWAFQAVAFNEVGFLLA 843
            |.::..:...:||:.:|.||.||.:..||.|.|.|:.: .|.:..||::.....||.|..|..||
Human   918 WMKFHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLN-SEVVLDQDAIDVIIHVARNPHGRDLA 981

  Fly   844 KKYFMDNVDFIYKFYHPLTKDMSRLLSPLSEQVITLSDFNEFKDFVNNSRQSLKGLEQA-IQQTL 907
            .|:|.|....:...|.......|:|:|.::|.:.|..:..|.|:|:.|    ..|:..| ..:.:
Human   982 WKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMKN----YDGVAAASFSRAV 1042

  Fly   908 EIMLTNVQWK 917
            |.:..||:||
Human  1043 ETVEANVRWK 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	139/408 (34%)
		M1_APN_2	43..502	CDD:189008	163/469 (35%)
		ERAP1_C	583..908	CDD:288671	99/329 (30%)
TRHDE	NP_037513.2	M1_APN-Q_like	193..638	CDD:341064	159/466 (34%)
TRHDE	NP_037513.2	ERAP1_C	723..1047	CDD:403137	101/334 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155374
Domainoid	1	1.000	108	1.000	Domainoid score	I6427
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.850